Natural polymer-stabilized multiple water-in-oil-in-water emulsions: A novel dermal drug delivery system for 5-fluorouracil

Journal of Pharmacy and Pharmacology

Volumn 66, Issue 5, 2014, Pages 658-667

  Hoppel, Magdalena ^a   Mahrhauser, Denise ^a   Stallinger, Christina ^a   Wagner, Florian ^a   Wirth, Michael ^a   Valenta, Claudia ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

5 fluorouracil; ATR FTIR; multiple emulsions; optical light microscopy; skin

Indexed keywords

DRUG CARRIER; FLUOROURACIL; OIL; POLYMER; SOLAGUM AX; UNCLASSIFIED DRUG; BACTERIAL POLYSACCHARIDE; EMULSION; LIPID; WATER; XANTHAN;

ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; EMULSION; HYDROPHILICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; SKIN PENETRATION; SKIN PERMEABILITY; STRATUM CORNEUM; SWINE; VIBRATION; VISCOSITY; ACACIA; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; SKIN;

ACACIA; ADMINISTRATION, CUTANEOUS; ANIMALS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FLUOROURACIL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; OILS; PARTICLE SIZE; POLYMERS; POLYSACCHARIDES, BACTERIAL; SKIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SWINE; VISCOSITY; WATER;

EID: 84899082428     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12194     Document Type: Article

References (36)

1. Schwarz JS, et al. Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir. Int J Pharm 2012; 435: 69-75.
2. Schmidts T, et al. Development of drug delivery systems for the dermal application of therapeutic DNAzymes. Int J Pharm 2012; 431: 61-69.
3. Bozkir A, Hayta G,. Preparation and evaluation of multiple emulsions water-in-oil-in-water (w/o/w) as delivery system for influenza virus antigens. J Drug Target 2004; 12: 157-164.
4. Tang SY, et al. Anti-inflammatory and analgesic activity of novel oral aspirin-loaded nanoemulsions generated using ultrasound cavitation. Int J Pharm 2012; 430: 299-306.
5. Qi X, et al. Water-in-oil-in-water double emulsions: an excellent delivery system for improving the oral bioavailability of pidotimod in rats. J Pharm Sci 2011; 100: 2203-2211.
6. Garti N,. Progress in stabilization and transport phenomena of double emulsions in food applications. Lebensm Wiss U Technol 1997; 30: 222-235.
7. Muschiolik G,. Multiple emulsions for food use. COCIS 2007; 12: 213-220.
8. Bonina F, et al. Three phase emulsions for controlled delivery in the cosmetic field. Int J Cosmet Sci 1992; 14: 65-74.
9. Laugel C, et al. Modulated release of triterpenic compounds from O/W/O multiple emulsion formulated with dimethicones: infrared spectrophotometric and differential calorimetric approaches. J Control Release 2000; 63: 7-17.
10. Matsumoto S, et al. An attempt at preparing water-in-oil-in-water multiple-phase emulsions. J Colloid Interface Sci 1976; 57: 353-361.
11. Beer S, et al. In line monitoring of the preparation of water-in-oil-in-water (W/O/W) type multiple emulsions via dielectric spectroscopy. Int J Pharm 2013; 441: 643-647.
12. Dickinson E,. Double emulsions stabilized by food biopolymers. Food Biophys 2011; 6: 1-11.
13. Anton N, et al. Reverse micelle-loaded lipid nano-emulsions: new technology for nano-encapsulation of hydrophilic materials. Int J Pharm 2010; 398: 204-209.
14. Morais JM, et al. W/O/W multiple emulsions obtained by one-step emulsification method and evaluation of the involved mechanisms. J Disper Sci Technol 2008; 29: 63-69.
15. Omotosho JA, et al. The nature of the oil phase and the release of solutes from multiple (w/o/w) emulsions. J Pharm Pharmacol 1986; 38: 865-870.
16. Singh BN, et al. Effects of ionization and penetration enhancers on the transdermal delivery of 5-fluorouracil through excised human stratum corneum. Int J Pharm 2005; 298: 98-107.
17. Klang V, et al. In vivo vs in vitro tape stripping: validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions. Eur J Pharm Biopharm 2012; 80: 604-614.
18. Schwarz JC, et al. Comparison of ATR-FTIR spectra of porcine vaginal and buccal mucosa with ear skin and penetration analysis of drug and vehicle components into pig ear. Eur J Pharm Sci 2013; 50: 595-600.
19. Yanyu X, et al. The influence of the structure and the composition of water/AOT-Tween 85/IPM microemulsion system on transdermal delivery of 5-fluorouracil. Drug Dev Ind Pharm 2012; 38: 1-9.
20. Olivieri L, et al. Optimization of a thermally reversible W/O/W multiple emulsion for shear-induced drug release. J Control Release 2003; 88: 401-412.
21. Hasanovic A, et al. Modification of the conformational skin structure by treatment with liposomal formulations and its correlation to the penetration depth of aciclovir. Eur J Pharm Biopharm 2011; 79: 76-81.
22. Obata Y, et al. Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers. Int J Pharm 2010; 389: 18-23.
23. Rodríguez G, et al. Application of bicellar systems on skin: diffusion and molecular organization effects. Langmuir 2010; 26: 10578-10584.
24. Rodríguez G, et al. Conformational changes in stratum corneum lipids by effect of bicellar systems. Langmuir 2009; 25: 10595-10603.
25. Hathout RM, et al. Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Mol Pharm 2010; 7: 1266-1273.
26. Savic S, et al. Natural surfactant-based topical vehicles for two model drugs: influence of different lipophilic excipients on in vitro/in vivo skin performance. Int J Pharm 2009; 381: 220-230.
27. Tadros T, et al. Formation and stability of nanoemulsions. Adv Colloid Interface Sci 2004; 108-109: 303-318.
28. Lane M,. Skin penetration enhancers. Int J Pharm 2013; 447: 12-21.
29. Sinha VR, Kaur MP,. Permeation enhancers for transdermal drug delivery. Drug Dev Ind Pharm 2000; 26: 1131-1140.
30. Lee EA, et al. Microemulsion-based hydrogel formulation of itraconazole for topical delivery. J Pharm Invest 2010; 40: 305-311.
31. Ferreira LAM, et al. In vitro percutaneous absorption of metronidazole and glucose: comparison of o/w, w/o/w and w/o systems. Int J Pharm 1995; 121: 169-179.
32. Tanojo H, et al. In vivo skin permeability enhancement by oleic acid: transepidermal water loss and Fourier-transform infrared spectroscopy studies. J Control Release 1997; 47: 31-39.
33. Forslind B,. A domain mosaic model of the skin barrier. Acta Derm Venereol 1994; 74: 1-6.
34. Bouwstra JA, et al. The lipid organization in the skin barrier. Arch Dermatol Res 2000; 208: 23-30.
35. Damien F, Boncheva M,. The extend of orthorhombic lipid phases in the stratum corneum determines the barrier efficiency of human skin in vivo. J Invest Dermatol 2010; 130: 611-614.
36. He W, et al. Study on the mechanisms of chitosan and its derivatives used as transdermal penetration enhancers. Int J Pharm 2009; 382: 235-243.