Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging

Age

Volumn 36, Issue 1, 2014, Pages 129-139

  Gu, Minxia ^a   Shen, Lihua ^a   Bai, Lei ^a   Gao, Junying ^a   Marshall, Charles ^b   Wu, Ting ^a   Ding, Jiong ^a   Miao, Dengshun ^a   Xiao, Ming ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Bmi 1; Brain aging; Reactive gliosis; Reactive oxygen species

Indexed keywords

3 NITROTYROSINE; BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2D; CYCLIN DEPENDENT KINASE INHIBITOR P53; HYDROXYL RADICAL; LIPOFUSCIN; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BMI 1 GENE; BRAIN AGING; BRAIN HOMOGENATE; CATARACT; CELL ACTIVATION; CELL PROLIFERATION; COGNITION; CONTROLLED STUDY; DOWN REGULATION; ELECTRON MICROSCOPY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; HAIR LOSS; HETEROZYGOSITY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KNOCKOUT MOUSE; LIPID PEROXIDATION; LOCOMOTION; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; ONCOGENE; ONCOGENE BCL 2; ONSET AGE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PIGMENTATION; PYRAMIDAL NERVE CELL; QUANTITATIVE ANALYSIS; SYNAPTIC TRANSMISSION; UPREGULATION; WESTERN BLOTTING;

AGING; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN; FLOW CYTOMETRY; GENE EXPRESSION; GLUTATHIONE; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LIPOFUSCIN; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PHENOTYPE; POLYCOMB REPRESSIVE COMPLEX 1; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TYROSINE;

EID: 84899079791     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-013-9552-9     Document Type: Article

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