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Volumn 14, Issue 4, 2014, Pages 439-452

Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science

Author keywords

biomarker; cancer; CNS; EGFRvIII; exosomes; extracellular vesicles; glioma; isocitrate dehydrogenase 1 2; microvesicles

Indexed keywords

B RAF KINASE; BINDING PROTEIN; BIOLOGICAL MARKER; CHI3L1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FAR UPSTREAM ELEMENT BINDING PROTEIN 1; HISTONE; HISTONE H3F3A; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHOSPHATASE; PROTEIN P53; TELOMERASE REVERSE TRANSCRIPTASE; TENSIN; UNCLASSIFIED DRUG; TUMOR MARKER;

EID: 84898976613     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2014.905202     Document Type: Review
Times cited : (70)

References (125)
  • 1
    • 79958822681 scopus 로고    scopus 로고
    • Differential activity of NADPHproducing dehydrogenases renders rodents unsuitable models to study IDH1R132 mutation effects in human glioblastoma
    • Atai NA, Renkema-Mills NA, Bosman J, et al. Differential activity of NADPHproducing dehydrogenases renders rodents unsuitable models to study IDH1R132 mutation effects in human glioblastoma. J Histochem Cytochem 2011; 59(5):489-503
    • (2011) J Histochem Cytochem , vol.59 , Issue.5 , pp. 489-503
    • Atai, N.A.1    Renkema-Mills, N.A.2    Bosman, J.3
  • 3
    • 84868023931 scopus 로고    scopus 로고
    • CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2005-2009
    • Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol 2012; 14(Suppl 5):v1-49
    • (2012) Neuro Oncol , vol.14 , Issue.SUPPL. 5
    • Dolecek, T.A.1    Propp, J.M.2    Stroup, N.E.3    Kruchko, C.4
  • 4
    • 0033037830 scopus 로고    scopus 로고
    • Central nervous system cancers in first-degree relatives and spouses
    • Grossman SA, Osman M, Hruban R, Piantadosi S. Central nervous system cancers in first-degree relatives and spouses. Cancer Invest 1999;17(5):299-308 (Pubitemid 29266701
    • (1999) Cancer Investigation , vol.17 , Issue.5 , pp. 299-308
    • Grossman, S.A.1    Osman, M.2    Hruban, R.3    Piantadosi, S.4
  • 6
    • 84855699824 scopus 로고    scopus 로고
    • Oncogenic viruses and tumor glucose metabolism: Like kids in a candy store
    • Noch E, Khalili K. Oncogenic viruses and tumor glucose metabolism: like kids in a candy store. Mol Cancer Ther 2012;11(1): 14-23
    • (2012) Mol Cancer Ther , vol.11 , Issue.1 , pp. 14-23
    • Noch, E.1    Khalili, K.2
  • 7
    • 39149136486 scopus 로고    scopus 로고
    • Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma
    • DOI 10.1215/15228517-2007-035
    • Mitchell DA, Xie W, Schmittling R, et al. Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with GBM. Neuro Oncol 2008;10(1):10-18 (Pubitemid 351250896
    • (2008) Neuro-Oncology , vol.10 , Issue.1 , pp. 10-18
    • Mitchell, D.A.1    Xie, W.2    Schmittling, R.3    Learn, C.4    Friedman, A.5    McLendon, R.E.6    Sampson, J.H.7
  • 8
    • 84859265740 scopus 로고    scopus 로고
    • Cytomegalovirus infection in early childhood
    • may be protective against GBM multiforme, while later infection is a risk factor
    • Lehrer S. Cytomegalovirus infection in early childhood may be protective against GBM multiforme, while later infection is a risk factor. Med Hypotheses 2012;78(5):657-8
    • (2012) Med Hypotheses , vol.78 , Issue.5 , pp. 657-6658
    • Lehrer, S.1
  • 9
    • 84878613012 scopus 로고    scopus 로고
    • Cytomegalovirus contributes to GBM in the context of tumor suppressor mutations
    • Price RL, Song J, Bingmer K, et al. Cytomegalovirus contributes to GBM in the context of tumor suppressor mutations. Cancer Res 2013;73(11):3441-50
    • (2013) Cancer Res , vol.73 , Issue.11 , pp. 3441-3450
    • Price, R.L.1    Song, J.2    Bingmer, K.3
  • 10
    • 79960412239 scopus 로고    scopus 로고
    • Is cytomegalovirus a therapeutic target in GBM?
    • Sampson JH, Mitchell DA. Is cytomegalovirus a therapeutic target in GBM? Clin Cancer Res 2011;17(14): 4619-21
    • (2011) Clin Cancer Res , vol.17 , Issue.14 , pp. 4619-4621
    • Sampson, J.H.1    Mitchell, D.A.2
  • 11
    • 78650153633 scopus 로고    scopus 로고
    • Tumour vascularization via endothelial differentiation of GBM stem-like cells
    • Ricci-Vitiani L, Pallini R, Biffoni M, et al. Tumour vascularization via endothelial differentiation of GBM stem-like cells. Nature 2010;468(7325):824-8
    • (2010) Nature , vol.468 , Issue.7325 , pp. 824-828
    • Ricci-Vitiani, L.1    Pallini, R.2    Biffoni, M.3
  • 12
    • 78650098659 scopus 로고    scopus 로고
    • GBM stem-like cells give rise to tumour endothelium
    • Wang R, Chadalavada K, Wilshire J, et al. GBM stem-like cells give rise to tumour endothelium. Nature 2010;468(7325): 829-33
    • (2010) Nature , vol.468 , Issue.7325 , pp. 829-833
    • Wang, R.1    Chadalavada, K.2    Wilshire, J.3
  • 13
    • 79958849271 scopus 로고    scopus 로고
    • Heterogeneity maintenance in GBM: A social network
    • Bonavia R, Inda MM, Cavenee WK, Furnari FB. Heterogeneity maintenance in GBM: a social network. Cancer Res 2011; 71(12):4055-60
    • (2011) Cancer Res , vol.71 , Issue.12 , pp. 4055-4060
    • Bonavia, R.1    Inda, M.M.2    Cavenee, W.K.3    Furnari, F.B.4
  • 14
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. New Engl J Med 2009;360(8):765-73
    • (2009) New Engl J Med , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 15
    • 84859940323 scopus 로고    scopus 로고
    • Characterizing mutational heterogeneity in a GBM patient with double recurrence
    • Nickel GC, Barnholtz-Sloan J, Gould MP, et al. Characterizing mutational heterogeneity in a GBM patient with double recurrence. PLoS One 2012;7(4): e35262
    • (2012) PLoS One , vol.7 , Issue.4
    • Nickel, G.C.1    Barnholtz-Sloan, J.2    Gould, M.P.3
  • 16
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of GBM characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of GBM characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010; 17(1):98-110
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 17
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr H, Weisenberger DJ, Diefes K, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010; 17(5):510-22
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3
  • 18
    • 0026548240 scopus 로고
    • Structural alterations of the epidermal growth factor receptor gene in human gliomas
    • Wong AJ, Ruppert JM, Bigner SH, et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA 1992; 89(7):2965-9
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.7 , pp. 2965-2969
    • Wong, A.J.1    Ruppert, J.M.2    Bigner, S.H.3
  • 19
    • 33845713180 scopus 로고    scopus 로고
    • Utilization and cost of health care services associated with primary malignant brain tumors in the United States
    • DOI 10.1007/s11060-006-9197-y
    • Kutikova L, Bowman L, Chang S, et al. Utilization and cost of health care services associated with primary malignant brain tumors in the United States. J Neurooncol 2007;81(1):61-5 (Pubitemid 44963990
    • (2007) Journal of Neuro-Oncology , vol.81 , Issue.1 , pp. 61-65
    • Kutikova, L.1    Bowman, L.2    Chang, S.3    Long, S.R.4    Thornton, D.E.5    Crown, W.H.6
  • 20
    • 84861964530 scopus 로고    scopus 로고
    • Occult tumors presenting with negative imaging: Analysis of the literature
    • Chittiboina P, Connor DE Jr, Caldito G, et al. Occult tumors presenting with negative imaging: analysis of the literature. J Neurosurg 2012;116(6):1195-203
    • (2012) J Neurosurg , vol.116 , Issue.6 , pp. 1195-1203
    • Chittiboina, P.1    Connor Jr., D.E.2    Caldito, G.3
  • 21
    • 84899013428 scopus 로고    scopus 로고
    • Available from: www.cdc.gov/nchs/data/hus/2011/123.pdf
  • 22
    • 84861113373 scopus 로고    scopus 로고
    • Imaging characteristics of oligodendrogliomas that predict grade
    • Khalid L, Carone M, Dumrongpisutikul N, et al. Imaging characteristics of oligodendrogliomas that predict grade. Am J Neuroradiol 2012;33(5):852-7
    • (2012) Am J Neuroradiol , vol.33 , Issue.5 , pp. 852-857
    • Khalid, L.1    Carone, M.2    Dumrongpisutikul, N.3
  • 24
    • 84863356217 scopus 로고    scopus 로고
    • Does MR perfusion imaging impact management decisions for patients with brain tumors? A prospective study
    • Geer CP, Simonds J, Anvery A, et al. Does MR perfusion imaging impact management decisions for patients with brain tumors? A prospective study. AJNR Am J Neuroradiol 2012;33(3):556-62
    • (2012) AJNR Am J Neuroradiol , vol.33 , Issue.3 , pp. 556-562
    • Geer, C.P.1    Simonds, J.2    Anvery, A.3
  • 25
    • 84866035483 scopus 로고    scopus 로고
    • New similarity search based glioma grading
    • Haegler K, Wiesmann M, Bohm C, et al. New similarity search based glioma grading. Neuroradiology 2012;54(8):829-37
    • (2012) Neuroradiology , vol.54 , Issue.8 , pp. 829-837
    • Haegler, K.1    Wiesmann, M.2    Bohm, C.3
  • 26
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human GBM genes and core pathways
    • McLendon R, Friedman A, Bigner D, et al. Comprehensive genomic characterization defines human GBM genes and core pathways. Nature 2008;455(7216):1061-8
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
    • McLendon, R.1    Friedman, A.2    Bigner, D.3
  • 27
    • 79959553090 scopus 로고    scopus 로고
    • Cytoreductive surgery of GBM as the key to successful adjuvant therapies: New arguments in an old discussion
    • Stummer W, Van Den Bent MJ, Westphal M. Cytoreductive surgery of GBM as the key to successful adjuvant therapies: new arguments in an old discussion. Acta Neurochir (Wien) 2011; 153(6):1211-18
    • (2011) Acta Neurochir (Wien , vol.153 , Issue.6 , pp. 1211-1218
    • Stummer, W.1    Van Den Bent, M.J.2    Westphal, M.3
  • 29
    • 83755225553 scopus 로고    scopus 로고
    • NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology
    • quiz S33
    • Febbo PG, Ladanyi M, Aldape KD, et al. NCCN Task Force report: evaluating the clinical utility of tumor markers in oncology. J Natl Compr Canc Netw 2011; 9(Suppl 5):S1-32; quiz S33
    • (2011) J Natl Compr Canc Netw , vol.9 , Issue.SUPPL. 5
    • Febbo, P.G.1    Ladanyi, M.2    Aldape, K.D.3
  • 31
    • 74049133168 scopus 로고    scopus 로고
    • The importance of surgical resection in malignant glioma
    • Stummer W, Kamp MA. The importance of surgical resection in malignant glioma. Curr Opin Neurol 2009;22(6):645-9
    • (2009) Curr Opin Neurol , vol.22 , Issue.6 , pp. 645-649
    • Stummer, W.1    Kamp, M.A.2
  • 32
    • 4744345914 scopus 로고    scopus 로고
    • Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with GBM multiforme: Report of Radiation Therapy Oncology Group 93-05 protocol
    • Souhami L, Seiferheld W, Brachman D, et al. Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with GBM multiforme: report of Radiation Therapy Oncology Group 93-05 protocol. Int J Radiat Oncol Biol Phys 2004;60(3): 853-60
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , Issue.3 , pp. 853-85860
    • Souhami, L.1    Seiferheld, W.2    Brachman, D.3
  • 35
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in GBM in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in GBM in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009;10(5):459-66
    • (2009) Lancet Oncol , vol.10 , Issue.5 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 37
    • 79960801311 scopus 로고    scopus 로고
    • Current concepts and management of GBM
    • Preusser M, De Ribaupierre S, Wohrer A, et al. Current concepts and management of GBM. Ann Neurol 2011;70(1):9-21
    • (2011) Ann Neurol , vol.70 , Issue.1 , pp. 9-21
    • Preusser, M.1    De Ribaupierre, S.2    Wohrer, A.3
  • 38
    • 68649114787 scopus 로고    scopus 로고
    • Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    • Gutin PH, Iwamoto FM, Beal K, et al. Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int J Radiat Oncol Biol Phys 2009;75(1):156-63
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.1 , pp. 156-163
    • Gutin, P.H.1    Iwamoto, F.M.2    Beal, K.3
  • 39
    • 49649104978 scopus 로고    scopus 로고
    • Mechanisms of chemoresistance to alkylating agents in malignant glioma
    • Sarkaria JN, Kitange GJ, James CD, et al. Mechanisms of chemoresistance to alkylating agents in malignant glioma. Clin Cancer Res 2008;14(10):2900-8
    • (2008) Clin Cancer Res , vol.14 , Issue.10 , pp. 2900-2908
    • Sarkaria, J.N.1    Kitange, G.J.2    James, C.D.3
  • 40
    • 68049095262 scopus 로고    scopus 로고
    • MSH6 mutations arise in GBMs during temozolomide therapy and mediate temozolomide resistance
    • Yip S, Miao J, Cahill DP, et al. MSH6 mutations arise in GBMs during temozolomide therapy and mediate temozolomide resistance. Clin Cancer Res 2009;15(14):4622-9
    • (2009) Clin Cancer Res , vol.15 , Issue.14 , pp. 4622-4629
    • Yip, S.1    Miao, J.2    Cahill, D.P.3
  • 43
    • 0029582768 scopus 로고
    • The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: Phase i trial
    • DOI 10.1007/BF01060217
    • Brem H, Ewend MG, Piantadosi S, et al. The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: phase I trial. J Neurooncol 1995;26(2):111-23 (Pubitemid 26003222
    • (1995) Journal of Neuro-Oncology , vol.26 , Issue.2 , pp. 111-123
    • Brem, H.1    Ewend, M.G.2    Piantadosi, S.3    Greenhoot, J.4    Burger, P.C.5    Sisti, M.6
  • 45
    • 70350142397 scopus 로고    scopus 로고
    • Patterns of relapse and prognosis after bevacizumab failure in recurrent GBM
    • Iwamoto FM, Abrey LE, Beal K, et al. Patterns of relapse and prognosis after bevacizumab failure in recurrent GBM. Neurology 2009;73(15):1200-6
    • (2009) Neurology , vol.73 , Issue.15 , pp. 1200-1206
    • Iwamoto, F.M.1    Abrey, L.E.2    Beal, K.3
  • 46
    • 56149110299 scopus 로고    scopus 로고
    • High-grade glioma before and after treatment with radiation and Avastin: Initial observations
    • Fischer I, Cunliffe CH, Bollo RJ, et al. High-grade glioma before and after treatment with radiation and Avastin: initial observations. Neuro Oncol 2008;10(5): 700-8
    • (2008) Neuro Oncol , vol.10 , Issue.5 , pp. 700-708
    • Fischer, I.1    Ch, C.2    Bollo, R.J.3
  • 47
    • 0036820488 scopus 로고    scopus 로고
    • Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis
    • discussion 919-920
    • Rock JP, Hearshen D, Scarpace L, et al. Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis. Neurosurgery 2002;51(4): 912-19; discussion 919-920
    • (2002) Neurosurgery , vol.51 , Issue.4 , pp. 912-919
    • Rock, J.P.1    Hearshen, D.2    Scarpace, L.3
  • 48
    • 84880339763 scopus 로고    scopus 로고
    • BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles
    • Chen WW, Balaj L, Liau LM, et al. BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles. Mol Ther Nucleic Acids 2013;2: e109
    • (2013) Mol Ther Nucleic Acids , vol.2
    • Chen, W.W.1    Balaj, L.2    Liau, L.M.3
  • 49
    • 84887508154 scopus 로고    scopus 로고
    • Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA
    • Hole P, Sillence K, Hannell C, et al. Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA). J Nanopart Res 2013;15:2101
    • (2013) J Nanopart Res , vol.15 , pp. 2101
    • Hole, P.1    Sillence, K.2    Hannell, C.3
  • 50
    • 57049103401 scopus 로고    scopus 로고
    • GBM microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Wurdinger T, Van Rijn S, et al. GBM microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008;10(12):1470-6
    • (2008) Nat Cell Biol , vol.10 , Issue.12 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van Rijn, S.3
  • 51
    • 84885577882 scopus 로고    scopus 로고
    • The complete exosome workflow solution: From isolation to characterization of RNA cargo
    • Schageman J, Zeringer E, Li M, et al. The complete exosome workflow solution: from isolation to characterization of RNA cargo. Biomed Res Int 2013;2013:253957
    • (2013) Biomed Res Int , vol.2013 , pp. 253957
    • Schageman, J.1    Zeringer, E.2    Li, M.3
  • 52
    • 79551608032 scopus 로고    scopus 로고
    • Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
    • Balaj L, Lessard R, Dai L, et al. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun 2011;2:180
    • (2011) Nat Commun , Issue.2 , pp. 180
    • Balaj, L.1    Lessard, R.2    Dai, L.3
  • 55
    • 84863361974 scopus 로고    scopus 로고
    • Pathology: Commonly monitored GBM markers: EFGR, EGFRvIII, PTEN, and MGMT
    • vIII
    • Camara-Quintana JQ, Nitta RT, Li G. Pathology: commonly monitored GBM markers: EFGR, EGFRvIII, PTEN, and MGMT. Neurosurg Clin N Am 2012; 23(2):237-46; vIII
    • (2012) Neurosurg Clin N Am , vol.23 , Issue.2 , pp. 237-246
    • Camara-Quintana, J.Q.1    Nitta, R.T.2    Li, G.3
  • 56
    • 84899003170 scopus 로고    scopus 로고
    • Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy
    • Oct 31
    • Weller M, Kaulich K, Hentschel B, et al. Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy. Int J Cancer 2013 Oct 31
    • (2013) Int J Cancer
    • Weller, M.1    Kaulich, K.2    Hentschel, B.3
  • 57
    • 84864051320 scopus 로고    scopus 로고
    • Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas
    • Li G, Mitra SS, Monje M, et al. Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas. J Neurooncol 2012;108(3): 395-402
    • (2012) J Neurooncol , vol.108 , Issue.3 , pp. 395-402
    • Li, G.1    Mitra, S.S.2    Monje, M.3
  • 58
    • 70350049243 scopus 로고    scopus 로고
    • Genetic signature of adult gliomas and correlation with MRI features
    • Bruzzone MG, Eoli M, Cuccarini V, et al. Genetic signature of adult gliomas and correlation with MRI features. Expert Rev Mol Diagn 2009;9(7):709-20
    • (2009) Expert Rev Mol Diagn , vol.9 , Issue.7 , pp. 709-720
    • Bruzzone, M.G.1    Eoli, M.2    Cuccarini, V.3
  • 59
    • 11944266853 scopus 로고    scopus 로고
    • Cellular antitumor immune response to a branched lysine multiple antigenic peptide containing epitopes of a common tumor-specific antigen in a rat glioma model
    • DOI 10.1007/s00262-004-0576-y
    • Ciesielski MJ, Kazim AL, Barth RF, Fenstermaker RA. Cellular antitumor immune response to a branched lysine multiple antigenic peptide containing epitopes of a common tumor-specific antigen in a rat glioma model. Cancer Immunol Immunother 2005;54(2):107-19 (Pubitemid 40100833
    • (2005) Cancer Immunology, Immunotherapy , vol.54 , Issue.2 , pp. 107-119
    • Ciesielski, M.J.1    Kazim, A.L.2    Barth, R.F.3    Fenstermaker, R.A.4
  • 61
    • 62449150719 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent GBM: EORTC brain tumor group study 26034
    • Van Den Bent MJ, Brandes AA, Rampling R, et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent GBM: EORTC brain tumor group study 26034. J Clin Oncol 2009;27(8):1268-74
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1268-1274
    • Van Den Bent, M.J.1    Brandes, A.A.2    Rampling, R.3
  • 62
    • 57149118473 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed GBMmultiforme: North Central Cancer Treatment Group Study N0177
    • Brown PD, Krishnan S, Sarkaria JN, et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed GBMmultiforme: north Central Cancer Treatment Group Study N0177. J Clin Oncol 2008;26(34):5603-9
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5603-5609
    • Brown, P.D.1    Krishnan, S.2    Sarkaria, J.N.3
  • 63
    • 84871617507 scopus 로고    scopus 로고
    • Diagnostic and therapeutic avenues for GBM: No longer a dead end?
    • Tanaka S, Louis DN, Curry WT, et al. Diagnostic and therapeutic avenues for GBM: no longer a dead end? Nat Rev Clin Oncol 2013;10(1):14-26
    • (2013) Nat Rev Clin Oncol , vol.10 , Issue.1 , pp. 14-26
    • Tanaka, S.1    Louis, D.N.2    Curry, W.T.3
  • 64
    • 84860790212 scopus 로고    scopus 로고
    • Review: Molecular pathology in adult high-grade gliomas: From molecular diagnostics to target therapies
    • Masui K, Cloughesy TF, Mischel PS. Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathol Appl Neurobiol 2012;38(3):271-91
    • (2012) Neuropathol Appl Neurobiol , vol.38 , Issue.3 , pp. 271-291
    • Masui, K.1    Cloughesy, T.F.2    Mischel, P.S.3
  • 65
    • 84880339763 scopus 로고    scopus 로고
    • BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles
    • Chen WW, Balaj L, Liau LM, et al. BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles. Mol Ther Nucleic Acid 2013;2: e109
    • (2013) Mol Ther Nucleic Acid , vol.2
    • Chen, W.W.1    Balaj, L.2    Liau, L.M.3
  • 66
    • 73349103157 scopus 로고    scopus 로고
    • Molecular predictors of progression-free and overall survival in patients with newly diagnosed GBM: A prospective translational study of the German Glioma Network
    • Weller M, Felsberg J, Hartmann C, et al. Molecular predictors of progression-free and overall survival in patients with newly diagnosed GBM: a prospective translational study of the German Glioma Network. J Clin Oncol 2009;27(34):5743-50
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5743-5750
    • Weller, M.1    Felsberg, J.2    Hartmann, C.3
  • 67
    • 84880300456 scopus 로고    scopus 로고
    • Oncogenic isocitrate dehydrogenase mutations: Mechanisms models and clinical opportunities
    • Cairns RA, Mak TW. Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov 2013;3(7):730-41
    • (2013) Cancer Discov , vol.3 , Issue.7 , pp. 730-741
    • Cairns, R.A.1    Mak, T.W.2
  • 68
    • 84873575930 scopus 로고    scopus 로고
    • Molecular genetics of low-grade gliomas: Genomic alterations guiding diagnosis and therapeutic intervention. 11th Annual Frye-Halloran Brain Tumor Symposium
    • Jones PS, Dunn GP, Barker FG II, et al. Molecular genetics of low-grade gliomas: genomic alterations guiding diagnosis and therapeutic intervention. 11th Annual Frye-Halloran Brain Tumor Symposium. Neurosurg Focus 2013;34(2):E9
    • (2013) Neurosurg Focus , vol.34 , Issue.2
    • Jones, P.S.1    Dunn, G.P.2    Barker, I.I.F.G.3
  • 69
    • 69949114447 scopus 로고    scopus 로고
    • Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: A study of 1,010 diffuse gliomas
    • Hartmann C, Meyer J, Balss J, et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol 2009;118(4): 469-74
    • (2009) Acta Neuropathol , vol.118 , Issue.4 , pp. 469-474
    • Hartmann, C.1    Meyer, J.2    Balss, J.3
  • 70
    • 82755194965 scopus 로고    scopus 로고
    • Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
    • Yip S, Butterfield YS, Morozova O, et al. Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol 2012;226(1):7-16
    • (2012) J Pathol , vol.226 , Issue.1 , pp. 7-16
    • Yip, S.1    Butterfield, Y.S.2    Morozova, O.3
  • 71
    • 84866411339 scopus 로고    scopus 로고
    • CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas
    • Sahm F, Koelsche C, Meyer J, et al. CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. Acta Neuropathol 2012; 123(6):853-60
    • (2012) Acta Neuropathol , vol.123 , Issue.6 , pp. 853-860
    • Sahm, F.1    Koelsche, C.2    Meyer, J.3
  • 72
    • 84868625787 scopus 로고    scopus 로고
    • Frequent ATRX CIC FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    • Jiao Y, Killela PJ, Reitman ZJ, et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget 2012;3(7): 709-22
    • (2012) Oncotarget , vol.3 , Issue.7 , pp. 709-722
    • Jiao, Y.1    Killela, P.J.2    Reitman, Z.J.3
  • 73
    • 22144489134 scopus 로고    scopus 로고
    • CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas
    • DOI 10.1007/s11060-004-4598-2
    • Lee CJ, Chan WI, Scotting PJ. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. J Neurooncol 2005; 73(2):101-8 (Pubitemid 40974029
    • (2005) Journal of Neuro-Oncology , vol.73 , Issue.2 , pp. 101-108
    • Lee, C.-J.1    Chan, W.-I.2    Scotting, P.J.3
  • 74
    • 80052608062 scopus 로고    scopus 로고
    • Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    • Bettegowda C, Agrawal N, Jiao Y, et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 2011; 333(6048):1453-5
    • (2011) Science , vol.333 , Issue.6048 , pp. 1453-1455
    • Bettegowda, C.1    Agrawal, N.2    Jiao, Y.3
  • 75
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric GBM
    • Schwartzentruber J, Korshunov A, Liu XY, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric GBM. Nature 2012;482(7384):226-31
    • (2012) Nature , vol.482 , Issue.7384 , pp. 226-231
    • Schwartzentruber, J.1    Korshunov, A.2    Liu, X.Y.3
  • 76
    • 84871020024 scopus 로고    scopus 로고
    • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
    • Liu XY, Gerges N, Korshunov A, et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol 2012;124(5):615-25
    • (2012) Acta Neuropathol , vol.124 , Issue.5 , pp. 615-625
    • Liu, X.Y.1    Gerges, N.2    Korshunov, A.3
  • 77
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • Killela PJ, Reitman ZJ, Jiao Y, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci USA 2013;110(15): 6021-6
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.15 , pp. 6021-6026
    • Killela, P.J.1    Reitman, Z.J.2    Jiao, Y.3
  • 78
    • 79954441895 scopus 로고    scopus 로고
    • Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    • Schindler G, Capper D, Meyer J, et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 2011;121(3):397-405
    • (2011) Acta Neuropathol , vol.121 , Issue.3 , pp. 397-405
    • Schindler, G.1    Capper, D.2    Meyer, J.3
  • 79
    • 76549137130 scopus 로고    scopus 로고
    • Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas
    • Schiffman JD, Hodgson JG, Vandenberg SR, et al. Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res 2010; 70(2):512-19
    • (2010) Cancer Res , vol.70 , Issue.2 , pp. 512-519
    • Schiffman, J.D.1    Hodgson, J.G.2    Vandenberg, S.R.3
  • 80
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364(26):2507-16
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 81
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 2012;366(8):707-14
    • (2012) N Engl J Med , vol.366 , Issue.8 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 82
    • 84875633228 scopus 로고    scopus 로고
    • The TERT MNS16A polymorphism contributes to cancer susceptibility: Meta-analysis of the current studies
    • Chen P, Zou P, Yan Q, et al. The TERT MNS16A polymorphism contributes to cancer susceptibility: meta-analysis of the current studies. Gene 2013;519(2):266-70
    • (2013) Gene , vol.519 , Issue.2 , pp. 266-270
    • Chen, P.1    Zou, P.2    Yan, Q.3
  • 83
    • 84862777410 scopus 로고    scopus 로고
    • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem GBMs
    • Wu G, Broniscer A, Mceachron TA, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem GBMs. Nat Genet 2012; 44(3):251-3
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 251-253
    • Wu, G.1    Broniscer, A.2    McEachron, T.A.3
  • 84
    • 84871683550 scopus 로고    scopus 로고
    • Effects of epidermal growth factor receptor and phosphatase and tensin homologue gene expression on the inhibition of U87MG GBM cell proliferation induced by protein kinase inhibitors
    • Xing WJ, Zou Y, Han QL, et al. Effects of epidermal growth factor receptor and phosphatase and tensin homologue gene expression on the inhibition of U87MG GBM cell proliferation induced by protein kinase inhibitors. Clin Exp Pharmacol Physiol 2013;40(1):13-21
    • (2013) Clin Exp Pharmacol Physiol , vol.40 , Issue.1 , pp. 13-21
    • Xing, W.J.1    Zou, Y.2    Han, Q.L.3
  • 85
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • Maheswaran S, Sequist LV, Nagrath S, et al. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 2008;359(4):366-77
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 366-377
    • Maheswaran, S.1    Sequist, L.V.2    Nagrath, S.3
  • 86
    • 78349232314 scopus 로고    scopus 로고
    • MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; A novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential
    • Jeuken JW, Wesseling P. MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential. J Pathol 2010;222(4): 324-8
    • (2010) J Pathol , vol.222 , Issue.4 , pp. 324-328
    • Jeuken, J.W.1    Wesseling, P.2
  • 87
    • 66849099801 scopus 로고    scopus 로고
    • Activation of the ERK/MAPK pathway: A signature genetic defect in posterior fossa pilocytic astrocytomas
    • Forshew T, Tatevossian RG, Lawson AR, et al. Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol 2009;218(2):172-81
    • (2009) J Pathol , vol.218 , Issue.2 , pp. 172-181
    • Forshew, T.1    Tatevossian, R.G.2    Lawson, A.R.3
  • 88
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones DT, Kocialkowski S, Liu L, et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 2008;68(21):8673-7
    • (2008) Cancer Res , vol.68 , Issue.21 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 89
    • 84355161678 scopus 로고    scopus 로고
    • Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: A multi-institutional study
    • Tihan T, Ersen A, Qaddoumi I, et al. Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: a multi-institutional study. Am J Surg Pathol 2012;36(1):43-55
    • (2012) Am J Surg Pathol , vol.36 , Issue.1 , pp. 43-55
    • Tihan, T.1    Ersen, A.2    Qaddoumi, I.3
  • 91
    • 67649873216 scopus 로고    scopus 로고
    • Extent of MGMT promoter methylation correlates with outcome in GBMs given temozolomide and radiotherapy
    • Dunn J, Baborie A, Alam F, et al. Extent of MGMT promoter methylation correlates with outcome in GBMs given temozolomide and radiotherapy. Br J Cancer 2009;101(1):124-31
    • (2009) Br J Cancer , vol.101 , Issue.1 , pp. 124-131
    • Dunn, J.1    Baborie, A.2    Alam, F.3
  • 92
    • 84855398150 scopus 로고    scopus 로고
    • Tumour and serum MGMT promoter methylation and protein expression in GBM patients
    • Balana C, Carrato C, Ramirez JL, et al. Tumour and serum MGMT promoter methylation and protein expression in GBM patients. Clin Transl Oncol 2011;13(9): 677-85
    • (2011) Clin Transl Oncol , vol.13 , Issue.9 , pp. 677-685
    • Balana, C.1    Carrato, C.2    Ramirez, J.L.3
  • 93
    • 32644467225 scopus 로고    scopus 로고
    • Methylated tumor-specific DNA as a plasma biomarker in patients with glioma
    • DOI 10.1080/07357900500449546, PII V072683716W551V2
    • Weaver KD, Grossman SA, Herman JG. Methylated tumor-specific DNA as a plasma biomarker in patients with glioma. Cancer Invest 2006;24(1):35-40 (Pubitemid 43247271
    • (2006) Cancer Investigation , vol.24 , Issue.1 , pp. 35-40
    • Weaver, K.D.1    Grossman, S.A.2    Herman, J.G.3
  • 95
    • 0036682413 scopus 로고    scopus 로고
    • Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma
    • Tanwar MK, Gilbert MR, Holland EC. Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma. Cancer Res 2002;62(15):4364-8 (Pubitemid 34827294
    • (2002) Cancer Research , vol.62 , Issue.15 , pp. 4364-4368
    • Tanwar, M.K.1    Gilbert, M.R.2    Holland, E.C.3
  • 96
    • 84864425646 scopus 로고    scopus 로고
    • Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    • Aug 2
    • Northcott PA, Shih DJ, Peacock J, et al. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 2012 Aug 2;488(7409):49-56
    • (2012) Nature , vol.488 , Issue.7409 , pp. 49-56
    • Northcott, P.A.1    Shih, D.J.2    Peacock, J.3
  • 97
    • 84877123057 scopus 로고    scopus 로고
    • NADP+ -dependent IDH1 R132 mutation and its relevance for glioma patient survival
    • Baldewpersad Tewarie NM, Burgers IA, Dawood Y, et al. NADP+ -dependent IDH1 R132 mutation and its relevance for glioma patient survival. Med Hypotheses 2013;80(6):728-31
    • (2013) Med Hypotheses , vol.80 , Issue.6 , pp. 728-731
    • Baldewpersad Tewarie, N.M.1    Burgers, I.A.2    Dawood, Y.3
  • 98
    • 0034947649 scopus 로고    scopus 로고
    • EGF mutant receptor vIII as a molecular target in cancer therapy
    • DOI 10.1677/erc.0.0080083
    • Kuan CT, Wikstrand CJ, Bigner DD. EGF mutant receptor vIII as a molecular target in cancer therapy. Endocr Relat Cancer 2001; 8(2):83-96 (Pubitemid 32641351
    • (2001) Endocrine-Related Cancer , vol.8 , Issue.2 , pp. 83-96
    • Kuan, C.-T.1    Wikstrand, C.J.2    Bigner, D.D.3
  • 99
    • 69949120572 scopus 로고    scopus 로고
    • EGFRvIII-targeted vaccination therapy of malignant glioma
    • Choi BD, Archer GE, Mitchell DA, et al. EGFRvIII-targeted vaccination therapy of malignant glioma. Brain Pathol 2009;19(4): 713-23
    • (2009) Brain Pathol , vol.19 , Issue.4 , pp. 713-723
    • Choi, B.D.1    Archer, G.E.2    Mitchell, D.A.3
  • 100
    • 84873204700 scopus 로고    scopus 로고
    • Rindopepimut: An evidence-based review of its therapeutic potential in the treatment of EGFRvIIIpositive GBM
    • Babu R, Adamson DC. Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIIIpositive GBM. Core Evid 2012;7:93-103
    • (2012) Core Evid , Issue.7 , pp. 93-103
    • Babu, R.1    Adamson, D.C.2
  • 102
    • 77955508065 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH: From mechanism to potential therapy
    • Fu Y, Huang R, Du J, et al. Glioma-derived mutations in IDH: from mechanism to potential therapy. Biochem Biophys Res Commun 2010;397(2):127-30
    • (2010) Biochem Biophys Res Commun , vol.397 , Issue.2 , pp. 127-130
    • Fu, Y.1    Huang, R.2    Du, J.3
  • 103
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013;340(6132): 626-30
    • (2013) Science , vol.340 , Issue.6132 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3
  • 104
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, Delabarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 2013;340(6132): 622-6
    • (2013) Science , vol.340 , Issue.6132 , pp. 622-626
    • Wang, F.1    Travins, J.2    Delabarre, B.3
  • 107
    • 79953184268 scopus 로고    scopus 로고
    • BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: Diagnostic and therapeutic implications
    • Dias-Santagata D, Lam Q, Vernovsky K, et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One 2011;6(3):e17948
    • (2011) PLoS One , vol.6 , Issue.3
    • Dias-Santagata, D.1    Lam, Q.2    Vernovsky, K.3
  • 108
    • 78751696744 scopus 로고    scopus 로고
    • Narrative review: BRAF opens the door for therapeutic advances in melanoma
    • Flaherty KT. Narrative review: BRAF opens the door for therapeutic advances in melanoma. Ann Intern Med 2010;153(9): 587-91
    • (2010) Ann Intern Med , vol.153 , Issue.9 , pp. 587-591
    • Flaherty, K.T.1
  • 109
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010; 363(9):809-19
    • (2010) N Engl J Med , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 110
    • 77957089182 scopus 로고    scopus 로고
    • The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
    • Joseph EW, Pratilas CA, Poulikakos PI, et al. The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner. Proc Natl Acad Sci USA 2010;107(33):14903-8
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.33 , pp. 14903-14908
    • Joseph, E.W.1    Pratilas, C.A.2    Poulikakos, P.I.3
  • 112
    • 79957523828 scopus 로고    scopus 로고
    • KRAS, BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
    • De Roock W, De Vriendt V, Normanno N, et al. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol 2011;12(6):594-603
    • (2011) Lancet Oncol , vol.12 , Issue.6 , pp. 594-603
    • De Roock, W.1    De Vriendt, V.2    Normanno, N.3
  • 113
    • 78650101872 scopus 로고    scopus 로고
    • Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes GBM cells to temozolomide
    • Bobustuc GC, Baker CH, Limaye A, et al. Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes GBM cells to temozolomide. Neuro-oncol 2010;12(9): 917-27
    • (2010) Neuro-oncol , vol.12 , Issue.9 , pp. 917-927
    • Bobustuc, G.C.1    Baker, C.H.2    Limaye, A.3
  • 114
    • 84857036712 scopus 로고    scopus 로고
    • Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: Association with tumor WHO grade and clinical outcome
    • Di Vinci A, Casciano I, Marasco E, et al. Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: association with tumor WHO grade and clinical outcome. J Cancer Res Clin Oncol 2012;138(1):35-47
    • (2012) J Cancer Res Clin Oncol , vol.138 , Issue.1 , pp. 35-47
    • Di Vinci, A.1    Casciano, I.2    Marasco, E.3
  • 116
    • 77954858289 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells
    • Chen W, Xiao BK, Liu JP, et al. Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells. Cancer Sci 2010;101(8):1769-76
    • (2010) Cancer Sci , vol.101 , Issue.8 , pp. 1769-1776
    • Chen, W.1    Xiao, B.K.2    Liu, J.P.3
  • 118
    • 0035884198 scopus 로고    scopus 로고
    • Paradigm shifts in clinical trials enabled by information technology
    • DOI 10.1002/sim.736
    • Marks RG, Conlon M, Ruberg SJ. Paradigm shifts in clinical trials enabled by information technology. Stat Med 2001; 20(17-18):2683-96 (Pubitemid 32834376
    • (2001) Statistics in Medicine , vol.20 , Issue.17-18 , pp. 2683-2696
    • Marks, R.G.1    Conlon, M.2    Ruberg, S.J.3
  • 119
    • 70350163204 scopus 로고    scopus 로고
    • Biomarker-driven early clinical trials in oncology: A paradigm shift in drug development
    • Tan DS, Thomas GV, Garrett MD, et al. Biomarker-driven early clinical trials in oncology: a paradigm shift in drug development. Cancer J 2009;15(5):406-20
    • (2009) Cancer J , vol.15 , Issue.5 , pp. 406-420
    • Tan, D.S.1    Thomas, G.V.2    Garrett, M.D.3
  • 120
    • 33745379412 scopus 로고    scopus 로고
    • BEAMing: Single-molecule PCR on microparticles in water-in-oil emulsions
    • DOI 10.1038/nmeth898, PII N898
    • Diehl F, Li M, He Y, et al. BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions. Nat Methods 2006; 3(7):551-9 (Pubitemid 43941774
    • (2006) Nature Methods , vol.3 , Issue.7 , pp. 551-559
    • Diehl, F.1    Li, M.2    He, Y.3    Kinzler, K.W.4    Vogelstein, B.5    Dressman, D.6
  • 121
    • 70249147655 scopus 로고    scopus 로고
    • Sensitive digital quantification of DNA methylation in clinical samples
    • Li M, Chen WD, Papadopoulos N, et al. Sensitive digital quantification of DNA methylation in clinical samples. Nat Biotechnol 2009;27(9):858-63
    • (2009) Nat Biotechnol , vol.27 , Issue.9 , pp. 858-863
    • Li, M.1    Chen, W.D.2    Papadopoulos, N.3
  • 122
    • 31744435976 scopus 로고    scopus 로고
    • BEAMing up for detection and quantification of rare sequence variants
    • DOI 10.1038/nmeth850, PII N850
    • Li M, Diehl F, Dressman D, et al. BEAMing up for detection and quantification of rare sequence variants. Nat Methods 2006;3(2):95-7 (Pubitemid 43173307
    • (2006) Nature Methods , vol.3 , Issue.2 , pp. 95-97
    • Li, M.1    Diehl, F.2    Dressman, D.3    Vogelstein, B.4    Kinzler, K.W.5
  • 123
    • 84890312241 scopus 로고    scopus 로고
    • Heparin blocks transfer of ectracellular vesicles between donor and recipient cells
    • Atai NA, Balaj L, Van Veen H, et al. Heparin blocks transfer of ectracellular vesicles between donor and recipient cells. J Neurooncol 2013;115(3):343-51
    • (2013) J Neurooncol , vol.115 , Issue.3 , pp. 343-351
    • Atai, N.A.1    Balaj, L.2    Van Veen, H.3
  • 124
    • 84870931536 scopus 로고    scopus 로고
    • Protein typing of circulating microvesicles allows real-time monitoring of GBM therapy
    • Shao H, Chung J, Balaj L, et al. Protein typing of circulating microvesicles allows real-time monitoring of GBM therapy. Nat Med 2012;18(12):1835-40
    • (2012) Nat Med , vol.18 , Issue.12 , pp. 1835-1840
    • Shao, H.1    Chung, J.2    Balaj, L.3
  • 125
    • 84871250894 scopus 로고    scopus 로고
    • Detection of IDH1 mutation in the plasma of patients with glioma
    • Boisselier B, Gallego Perez-Larraya J, Rossetto M, et al. Detection of IDH1 mutation in the plasma of patients with glioma. Neurology 2012;79(16): 1693-8
    • (2012) Neurology , vol.79 , Issue.16 , pp. 1693-1698
    • Boisselier, B.1    Gallego Perez-Larraya, J.2    Rossetto, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.