Synthesis of 1,1-disubstituted tetrahydroisoquinolines by lithiation and substitution, with in situ IR spectroscopy and configurational stability studies

Journal of the American Chemical Society

Volumn 136, Issue 15, 2014, Pages 5551-5554

  Li, Xiabing ^a   Coldham, Iain ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMISTRY; SYNTHESIS (CHEMICAL);

ASYMMETRIC SYNTHESIS; CONFIGURATIONAL STABILITY; CONFIGURATIONALLY; ENANTIOMERIZATION; LOW TEMPERATURES; ORGANOLITHIUMS; SOLIFENACIN; TETRAHYDROISOQUINOLINES;

ENANTIOMERS;

1,1 DISUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVE; CARBAMIC ACID; FR 115427; ISOQUINOLINE DERIVATIVE; ORGANOLITHIUM COMPOUND; SOLIFENACIN; UNCLASSIFIED DRUG; LITHIUM; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; ENANTIOMER; INFRARED SPECTROSCOPY; LITHIATION; SUBSTITUTION REACTION; CHEMISTRY; INFRARED SPECTROPHOTOMETRY; PROCEDURES; SYNTHESIS;

LITHIUM; SPECTROPHOTOMETRY, INFRARED; TETRAHYDROISOQUINOLINES;

EID: 84898969443     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja500485f     Document Type: Article

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