Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: In situ react IR spectroscopic monitoring, scope, and synthetic applications

Journal of Organic Chemistry

Volumn 76, Issue 15, 2011, Pages 5936-5953

  Barker, Graeme ^a   McGrath, Julia L ^a   Klapars, Artis ^b   Stead, Darren ^a   Zhou, George ^b   Campos, Kevin R ^b   O'Brien, Peter ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYL BROMIDES; ARYLATIONS; COMPREHENSIVE STUDIES; COUPLING REACTION; ENANTIOSELECTIVE; IN-SITU; NATURALLY OCCURRING; NEGISHI COUPLING; PYRROLIDINES; SPECTROSCOPIC MONITORING; SYNTHETIC APPLICATION; SYNTHETIC ROUTES; TOTAL SYNTHESIS; TRANSMETALATION; VINYL BROMIDES; VINYLATION;

BROMINE COMPOUNDS; CATALYSIS; SYNTHESIS (CHEMICAL);

AROMATIC COMPOUNDS;

BROMIDE; N BOC PYRROLIDINE; NICOTINE; PALLADIUM; PYRROLIDINE DERIVATIVE; SPARTEINE; UNCLASSIFIED DRUG;

ALPHA ARYLATION; ARTICLE; ARYLATION; ASYMMETRIC CATALYSIS; CATALYSIS; ENANTIOSELECTIVITY; INFRARED SPECTROSCOPY; LITHIATION;

CATALYSIS; ISOQUINOLINES; MOLECULAR STRUCTURE; PALLADIUM; PYRIDINES; PYRROLIDINES; SPARTEINE; SPECTRUM ANALYSIS; STEREOISOMERISM;

EID: 79961091837     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo2011347     Document Type: Article

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