Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products

Journal of the American Chemical Society

Volumn 135, Issue 29, 2013, Pages 10863-10869

  Ghislieri, Diego ^a   Green, Anthony P ^a   Pontini, Marta ^a   Willies, Simon C ^a   Rowles, Ian ^a   Frank, Annika ^b   Grogan, Gideon ^b   Turner, Nicholas J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; AMINODIPHENYLMETHANE; ASYMMETRIC SYNTHESIS; DEVELOPMENT AND APPLICATIONS; ENANTIOMERIC EXCESS; FINE CHEMICAL INDUSTRY; HIGH-THROUGHPUT SCREENING; STERICALLY DEMANDING;

ASPERGILLUS; CHEMICAL INDUSTRY; ENANTIOMERS; SUBSTITUTION REACTIONS; SUBSTRATES;

ENANTIOSELECTIVITY;

4,4' METHYLENEDIANILINE; ALKALOID DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING); CONIINE; ELEAGNINE; HARMICINE; LEPTAFLORINE; LEVOCETIRIZINE; SOLIFENACIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; ASPERGILLUS NIGER; ASYMMETRIC SYNTHESIS; BIOCATALYSIS; BIOTRANSFORMATION; CHIRALITY; CRYSTAL STRUCTURE; ENANTIOSELECTIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME SUBSTRATE; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PICTET SPENGLER REACTION; RACEMIZATION; STEREOCHEMISTRY; SUBSTITUTION REACTION;

ALKALOIDS; ASPERGILLUS NIGER; BENZHYDRYL COMPOUNDS; BIOLOGICAL PRODUCTS; INDOLE ALKALOIDS; MODELS, MOLECULAR; MONOAMINE OXIDASE; OXIDATION-REDUCTION; PROTEIN ENGINEERING; STEREOISOMERISM;

EID: 84880831531     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4051235     Document Type: Article

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