A convenient synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines via Pictet-Spengler reaction using titanium(IV) isopropoxide and acetic-formic anhydride

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 2, 2002, Pages 253-257

  Horiguchi, Yoshie ^a   Kodama, Hirokazu ^a   Nakamura, Masayoshi ^a   Yoshimura, Tsuyoshi ^a   Hanezi, Kaori ^a   Hamada, Hiroko ^a   Saitoh, Toshiaki ^a   Sano, Takehiro ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

1,2,3,4 tetrahydroisoquinoline; Acyliminium ion; N formylation; Pictet Spengler reaction; Titanium(IV) isopropoxide

Indexed keywords

1 ETHYL 6,7 DIMETHOXY 1 METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 6 METHOXY 1 METHYL 1 PHENYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 6 METHOXY 1,1 DIMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 6,7 DIMETHOXY 1 METHYL 1 PHENYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 6,7 DIMETHOXY 1 METHYL 1 PHENYLSULFANYLMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 6,7 DIMETHOXY 1,1 DIMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 1 SPIRO 1' INDANE; 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 1 SPIROCYCLOHEXANE; 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 1 SPIROCYCLOPENTANE; ACETIC ACID; ETHYLAMINE; FORMIC ACID; ISOQUINOLINE DERIVATIVE; KETONE DERIVATIVE; N FORMYL 1,2,3,4 TETRAHYDROISOQUINOLINE; TITANIUM DERIVATIVE; TITANIUM ISOPROPOXIDE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; ACID ANHYDRIDE; TITANIUM;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; PICTET SPENGLER REACTION; SUBSTITUTION REACTION; SYNTHESIS;

ANHYDRIDES; ISOQUINOLINES; TITANIUM;

EID: 0036482884     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.253     Document Type: Article

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