Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine

Chemistry - A European Journal

Volumn 19, Issue 24, 2013, Pages 7724-7730

  Li, Xiabing ^a   Leonori, Daniele ^a   Sheikh, Nadeem S ^a   Coldham, Iain ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

alkaloids; carbanions; heterocyclic compounds; IR spectroscopy; metalation

Indexed keywords

CARBANIONS; CONFIGURATIONALLY; EFFICIENT SYNTHESIS; HETEROCYCLIC COMPOUND; METALATIONS; OPTIMUM CONDITIONS; TETRAHYDROISOQUINOLINES; VARIABLE-TEMPERATURE NMR;

ALKALOIDS; AROMATIC COMPOUNDS; INFRARED SPECTROSCOPY; METABOLITES; NITROGEN COMPOUNDS;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

1,2,3,4-TETRAHYDROISOQUINOLINE; ALKALOID; CARNEGINE; HELIAMINE; ISOQUINOLINE DERIVATIVE; LAUDANOSINE; LIGAND; SALSOLIDINE; SALSOLINE DERIVATIVE; SPARTEINE; TETRAHYDROISOQUINOLINE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; CHEMISTRY; HUMAN; INFRARED SPECTROPHOTOMETRY; MALE; NUCLEAR MAGNETIC RESONANCE; STEREOISOMERISM; SYNTHESIS;

ALKALOIDS; HUMANS; ISOQUINOLINES; LIGANDS; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SALSOLINE ALKALOIDS; SPARTEINE; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM; TETRAHYDROISOQUINOLINES;

EID: 84878596725     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201301096     Document Type: Article

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