PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice

Gastroenterology

Volumn 146, Issue 5, 2014, Pages

  Li, Xin ^a   Stevens, Payton D ^a   Liu, Jianyu ^a   Yang, Haihua ^b   Wang, Wei ^a   Wang, Chi ^a   Zeng, Zheng ^a   Schmidt, Micheal D ^a   Yang, Mike ^c   Lee, Eun Y ^d   Gao, Tianyan ^a,e  

^a UNIVERSITY OF KENTUCKY   (United States)

^b TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE   (China)

^c Paul Laurence Dunbar High School   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Colorectal Cancer; Keywords; Metastasis; Phosphatase; Tumor Suppressor

Indexed keywords

CYTOKERATIN 20; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1; PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 2; PHOSPHOPROTEIN PHOSPHATASE; RAF PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER SURVIVAL; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; IMMUNOPRECIPITATION; LIFESPAN; MASS SPECTROMETRY; MOUSE; NONHUMAN; NONSENSE MUTATION; PENETRANCE; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

COLORECTAL CANCER; METASTASIS; PHOSPHATASE; TUMOR SUPPRESSOR;

ADENOCARCINOMA; ADENOMA; ANIMALS; APOPTOSIS; CADHERINS; CELL LINE; CELL MOVEMENT; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, APC; HUMANS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR BURDEN;

EID: 84898961798     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.02.003     Document Type: Article

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