Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

EMBO Reports

Volumn 12, Issue 8, 2011, Pages 818-824

  Li, Xin ^a   Yang, Haihua ^b   Liu, Jianyu ^a   Schmidt, Micheal D ^c   Gao, Tianyan ^a,d  

^a UNIVERSITY OF KENTUCKY   (United States)

^b TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Akt phosphorylation; PHLPP; scaffolding protein; Scribble

Indexed keywords

CELL MEMBRANE PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; PROTEIN PHLPP1; PROTEIN SCRIBBLE; TUBULIN; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

CACO-2 CELLS; CELL GROWTH PROCESSES; CELL MEMBRANE; CYTOPLASM; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; MEMBRANE PROTEINS; NUCLEAR PROTEINS; PDZ DOMAINS; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 79961032746     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2011.106     Document Type: Article

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