Novel isoxazole polycyclic aromatic hydrocarbons as DNA-intercalating agents

European Journal of Medicinal Chemistry

Volumn 51, Issue , 2012, Pages 163-173

  Rescifina, Antonio ^a   Varrica, Maria Giulia ^a   Carnovale, Caterina ^b   Romeo, Giovanni ^b   Chiacchio, Ugo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

1,3 Dipolar cycloaddition; Antitumor agent; DNA intercalation; Docking; Isoxazole; Polycyclic aromatic hydrocarbons

Indexed keywords

2 BENZYL N,N DIMETHYL 3 (PYREN 1 YL)ISOXAZOLIDINE 5 CARBOXAMIDE; ISOXAZOLE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG DNA INTERACTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LUNG CANCER; MOLECULAR DOCKING;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; DNA; HUMANS; INTERCALATING AGENTS; ISOXAZOLES; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; POLYCYCLIC HYDROCARBONS, AROMATIC;

EID: 84860299940     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.038     Document Type: Article

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