Role of intracellular events in the pathogenesis of dengue; An overview

Microbial Pathogenesis

Volumn 69-70, Issue 1, 2014, Pages 45-52

  Jain, Bhawana ^a   Chaturvedi, Umesh C ^a,b   Jain, Amita ^a  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b INDIAN COUNCIL OF MEDICAL RESEARCH   (India)

Author keywords

Autophagy; Dengue; Lipid droplets; Processing bodies; Stress granules

Indexed keywords

ADENOSINE TRIPHOSPHATE; FAT DROPLET; INITIATION FACTOR 2ALPHA; MESSENGER RNA;

AUTOPHAGY; CELL FUNCTION; CELL TYPE; DENGUE; DENGUE VIRUS; ENDOPLASMIC RETICULUM STRESS; HUMAN; LIPID OXIDATION; LIPOPHAGOCYTOSIS; MICROBIAL DEGRADATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROCESSING BODY; PROTEIN PHOSPHORYLATION; REVIEW; STRESS GRANULE; UNFOLDED PROTEIN RESPONSE; VIRUS ASSEMBLY; VIRUS CELL INTERACTION; VIRUS REPLICATION; APOPTOSIS; HOST PATHOGEN INTERACTION; PHYSIOLOGY;

APOPTOSIS; DENGUE VIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; VIRUS REPLICATION;

EID: 84898893842     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2014.03.004     Document Type: Review

References (101)

1. Gupta N., Srivastava S., Jain A., Chaturvedi U.C. Dengue in India. Indian J Med Res 2012, 136(3):373-390.
2. Bhatt S., Gething P.W., Brady O.J., Messina J.P., Farlow A.W., Moyes C.L., et al. The global distribution and burden of dengue. Nature 2013, 10.1038/nature12060.
3. Basu A., Chaturvedi U.C. Vascular endothelium: the battlefield of dengue viruses. FEMS Immunol Med Microbiol 2008, 53:287-299.
4. World Health Organization Dengue: guideline for diagnosis, treatment, prevention and control 2009, World Health Organization, Geneva.
5. Jain A., Chaturvedi U.C. Dengue in infants: an overview. FEMS Immunol Med Microbiol 2010, 59(2):119-130.
6. Halstead S.B. Neutralization and antibody-dependent enhancement of dengue viruses. Adv Virus Res 2003, 60:421-467.
7. Halstead S.B. Antibodies determine virulence in dengue. Ann N Y Acad Sci 2009, 1171(Suppl. 1):E48-E56.
8. Chaturvedi U.C., Raghupathy R., Pacsa A.S., Elbishbishi E.A., Agarwal R., Nagar R., et al. Shift from a Th1-type response to Th2-type in dengue haemorrhagic fever. Curr Sci 1999, 76:63-69.
9. Chaturvedi U.C., Shrivastava S., Tripathi R.K., Nagar R. Dengue virus-specific suppressor T cell: current perspectives. FEMS Immunol Med 2007, 50:285-299.
10. Mukerjee R., Chaturvedi U.C., Dhawan R. Dengue virus-induced human cytotoxic factor: production by peripheral blood leucocytes in vitro. Clin Exp Immunol 1995, 101:261-267.
11. Mukerjee R., Chaturvedi U.C., Vaughn D.W., Kalayanarooj S. Purification and pathogenicity of the cytotoxic factor from the cases of dengue haemorrhagic fever. Curr Sci 1997, 72:494-501.
12. Chaturvedi U.C., Agarwal R., Elbishbishi E.A., Mustafa A.S. Cytokine cascade in dengue haemorrhagic fever: implications for pathogenesis. FEMS Immunol Med Microbiol 2000, 28:183-188.
13. Rathakrishnan A., Wang S.M., Hu Y., Khan A.M., Ponnampalavanar S., Lum L.C., et al. Cytokine expression profile of dengue patients at different phases of illness. PLoS One 2012, 7(12):e52215. 10.1371/journal.pone.0052215.
14. Chaturvedi U.C., Nagar R., Shrivastava S. Dengue and dengue haemorrhagic fever: implications of host genetics. FEMS Immunol Med Microbiol 2006, 47:155-166.
15. Basu A., Chaturvedi U.C. Recent advances in understanding the intracellular responses to dengue virus infection. Future Virol 2010, 5:255-257. (Invited editorial).
16. Chaturvedi U.C., Nagar R., Shrivastava S. Macrophage and dengue virus: friend or foe?. Indian J Med Res 2006, 124:23-40.
17. Bartenachlager R., Miller S. Molecular aspects of dengue virus replication. Future Microbiol 2008 Apr, 3:155-165.
18. Mukhopadhyay S., Kuhn R.J., Rossmann M.G. A structural perspective of the flavivirus life cycle. Nat Rev Microbiol. 2005 Jan, 3(1):13-22.
19. Mackenzie J.M., Jones M.K., Westaway E.G. Markers for trans Golgi membranes and the intermediate compartment localize to induced membranes with distinct replication functions in flavivirus-infected cells. J Virol 1999 Nov, 73(11):9555-9567.
20. Chaturvedi U.C., Shrivastava R., Nagar R. Dengue vaccines: prospects and problems. Indian J Med Res 2005, 121:639-652.
21. Mizushima N., Yamamoto A., Matsui M., Yoshimori T., Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004, 15:1101-1111.
22. Kovacs J.R., Li C., Yang Q., Li G., Garcia I.G., Ju S., et al. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ 2012, 19:144-152.
23. Harris J. Autophagy and cytokines. Cytokine 2011, 56:140-144.
24. Mizushima N. Autophagy: process and function. Genes Dev 2007, 21:2861-2873.
25. Bhattacharya A., Eissa N.T. Autophagy and autoimmunity crosstalks. Front Immunol 2013, 15(4):88. 10.3389/fimmu.2013.00088.
26. Chiramel A.I., Brady N.R., Bartenschlager R. Divergent roles of autophagy in virus infection. Cells 2013, 2:83-104. 10.3390/cells2010083.
27. Orvedahl A., MacPherson S., Sumpter R., Talloczy Z., Zou Z., Levine B. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe 2010, 7:115-127.
28. Ke P.Y., Chen S.S. Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. J Clin Invest 2011, 121:37-56.
29. Joubert P.E., Meiffren G., Gregoire I.P., Pontini G., Richetta C., Flacher M., et al. Autophagy induction by the pathogen receptor CD46. Cell Host Microbe 2009, 6:354-366.
30. Denizot M., Varbanov M., Espert L., Robert-Hebmann V., Sagnier S., Garcia E., et al. HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells. Autophagy 2008, 8(4):998-1008.
31. Nakamoto M., Moy R.H., Xu J., Bambina S., Yasunaga A., Shelly S.S., et al. Virus recognition by Toll-7 activates antiviral autophagy in Drosophila. Immunity 2012, 36:658-667.
32. Kroemer G., Marino G., Levine B. Autophagy and the integrated stress response. Mol Cell 2010, 40:280-293.
33. McLean J.E., Wudzinska A., Datan E., Quaglino D., Zakeri Z. Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. J Biol Chem 2011, 286:22147-22159.
34. Liang C.E.X., Jung J.U. Downregulation of autophagy by herpesvirus Bcl-2 homologs. Autophagy 2008, 4:268-272.
35. Ku B., Woo J.S., Liang C., Lee K.H., Hong H.S., E X., et al. Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PLoS Pathog 2008, 4:e25.
36. Orvedahl A., Alexander D., Talloczy Z., Sun Q., Wei Y., Zhang W., et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe 2007, 1:23-35.
37. Kyei G.B., Dinkins C., Davis A.S., Roberts E., Singh S.B., Dong C., et al. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol 2009, 186:255-268.
38. Gannage M., Dormann D., Albrecht R., Dengjel J., Torossi T., Ramer P.C., et al. Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe 2009, 6:367-380.
39. Kemball C.C., Alirezaei M., Flynn C.T., Wood M.R., Harkins S., Kiosses W.B., et al. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. J Virol 2010, I84:12110-12124.
40. Jackson W.T., Giddings T.H., Taylor M.P., Mulinyawe S., Rabinovitch M., Kopito R.R., et al. Subversion of cellular autophagosomal machinery by RNA viruses. Plos Biol 2005, 3:e156.
41. Orvedahl A., Sumpter R., Xiao G., Ng A., Zou Z., Tang Y., et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 2011, 480:113-117.
42. English L., Chemali M., Duron J., Rondeau C., Laplante A., Gingras D., et al. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol 2009, 10:480-487.
43. Paludan C., Schmid D., Landthaler M., Vockerodt M., Kube D., Tuschl T., et al. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 2005, 307:593-596.
44. Schmid D., Pypaert M., Munz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007, 26:79-92.
45. Schlegel A., Giddings T.H., Ladinsky M.S., Kirkegaard K. Cellular origin and ultrastructure of membranes induced during poliovirus infection. J Virol 1996, 70:6576-6588.
46. Sir D., Kuo C.F., Tian Y., Liu H.M., Huang E.J., Jung J.U., et al. Replication of hepatitis C virus RNA on autophagosomal membranes. J Biol Chem 2012, 287:18036-18043.
47. Berkova Z., Crawford S.E., Trugnan G., Yoshimori T., Morris A.P., Estes M.K. Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms. J Virol 2006, 80:6061-6071.
48. Heaton N.S., Randall G. Dengue virus and autophagy. Viruses 2011, 3(8):1332-1341.
49. Li J., Liu Y., Wang Z., Liu K., Wang Y., Liu J., et al. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. J Virol 2011, 85:6319-6333.
50. Gregoire I.P., Richetta C., Meyniel-Schicklin L., Borel S., Pradezynski F., Diaz O., et al. IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog 2011, 7:e1002422.
51. Tonry J.H., Xiao S.Y., Siirin M., Chen H., da Rosa A.P., Tesh R.B. Am J Trop Med Hyg 2005, 72:320-324. [PubMed: 15772329].
52. Siirin M.T., Duan T., Lei H., Guzman H., da Rosa A.P., Watts D.M., et al. Am J Trop Med Hyg 2007, 76:299-306. [PubMed: 17297039].
53. Murray K., Walker C., Herrington E., Lewis J.A., McCormick J., Beasley D.W., et al. J Infect Dis 2010, 201:2-4. [PMCID: PMC2791189] [PubMed: 19961306].
54. Lee Y.R., Lei H.Y., Liu M.T., Wang J.R., Chen S.H., Jiang-Shieh Y.F., et al. Autophagic machinery activated by dengue virus enhances virus replication. Virology 2008, 374:240-248.
55. Panyasrivanit M., Khakpoor A., Wikan N., Smith D.R. Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes. J Gen Virol 2009, 90:448-456.
56. Khakpoor A., Panyasrivanit M., Wikan N., Smith D.R. A role for autophagolysosomes in dengue virus 3 production in HepG2 cells. J Gen Virol 2009, 90:1093-1103.
57. Welsch S., Miller S., Romero-Brey I., Merz A., Bleck C.K., Walther P., et al. Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe 2009, 5:365-375.
58. Mateo R., Nagamine C.M., Spagnolo J., Méndez E., Rahe M., Gale M., et al. Inhibition of cellular autophagy deranges dengue virion maturation. J Virol 2013, 87(3):1312-1321.
59. Halstead S.B., Mahalingam S., Marovich M.A., Ubol S., Mosser D.M. Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes. Lancet Infect Dis 2010, 10(10):712-722.
60. Panyasrivanit M., Greenwood M.P., Murphy D., Isidoro C., Auewarakul P., Smith D.R. Induced autophagy reduces virus output in dengue infected monocytic cells. Virology 2011, 418:74-84.
61. Roingeard P., Depla M. The birth and life of lipid droplets: learning from the hepatitis C virus. Biol Cell 2011, 103:223-231.
62. Roingeard P., Hourioux C., Blanchard E., Prensier G. Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopy. Histochem Cell Biol 2008, 130:561-566.
63. Boulant S., Douglas M.W., Moody L., Budkowska A., Targett-Adams P., McLauchlan J. Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner. Traffic 2008, 9:1268-1282.
64. Miyanari Y., Atsuzawa K., Usuda N., Watashi K., Hishiki T., Zayas R., et al. The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 2007, 9:1089-1097.
65. Hapala I., Marza E., Ferreira T. Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation. Biol Cell 2011, 103:271-285.
66. Samsa M.M., Mondotte J.A., Iglesias N.G., Assuncao-Miranda I., Barbosa-Lima G., Da Poian A.T., et al. Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog 2009, 5:e1000632.
67. Peña J., Harris E. Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway. PLoS One 2012, 6:e38202. 10.1371/journal.pone.0038202.
68. Liu K., Czaja M.J. Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ 2013, 20:3-11.
69. Ait-Goughoulte M., Kanda T., Meyer K., Ryerse J.S., Ray R.B., Ray R. Hepatitis C virus genotype 1a growth and induction of autophagy. J Virol 2008, 82:2241-2249.
70. Sir D., Tian Y., Chen W.L., Ann D.K., Yen T.S., Ou J.H. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci U S A 2010, 107:4383-4388.
71. McLauchlan J. Hepatitis C virus: viral proteins on the move. Biochem Soc Trans 2009, 37:986-990.
72. Heaton N.S., Randall G. Dengue virus-induced autophagy regulates lipid metabolism. Cell Host Microbe 2010, 8:422-432.
73. Heaton N.S., Perera R., Berger K.L., Khadka S., Lacount D.J., Kuhn R.J., et al. Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci U S A 2010, 107:17345-17350.
74. Zhang L., Wang A. Virus-induced ER stress and the unfolded protein response. Front Plant Sci 2012, 3:293. 10.3389/fpls.2012.00293.
75. Lee D.Y., Lee J., Sugden B. The unfolded protein response and autophagy: herpesviruses rule!. J Virol 2009, 83(3):1168-1172.
76. Schroder M. Endoplasmic reticulum stress responses. Cell Mol Life Sci 2008, 65(6):862-894.
77. Munz C. Enhancing immunity through autophagy. Annu Rev Immunol 2009, 27:423-449.
78. Umareddy I., Pluquet O., Wang Q.Y., Vasudevan S.G., Chevet E., Gu F. Dengue virus serotype infection specifies the activation of the unfolded protein response. Virol J 2007, 4:91.
79. Peña J., Harris E. Dengue virus modulates the unfolded protein response in a time-dependent manner. J Biol Chem 2011, 286(16):14226-14236.
80. Paradkar P.N., Ooi E.E., Hanson B.J., Gubler D.J., Vasudevan S.G. Unfolded protein response (UPR) gene expression during antibody-dependent enhanced infection of cultured monocytes correlates with dengue disease severity. Biosci Rep 2011, 31(3):221-230.
81. Anderson P., Kedersha N. RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol 2009, 10:430-436.
82. Eulalio A., Behm-Ansmant I., Izaurralde E. P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 2007, 8:9-22.
83. Buchan J.R., Muhlrad D., Parker R. P bodies promote stress granule assembly in Saccharomyces cerevisiae. J Cell Biol 2008, 183:441-455.
84. Lloyd R.E. How do viruses interact with stress-associated RNA granules?. PLoS Pathog 2012, 8(6):e1002741. 10.1371/journal.ppat.1002741.
85. White J.P., Lloyd R.E. Regulation of stress granules in virus systems. Trends Microbiol 2012, 20:175-183.
86. Piotrowska J., Hansen S.J., Park N., Jamka K., Sarnow P., Gustin K.E. Stable formation of compositionally unique stress granules in virus-infected cells. J Virol 2010, 84:3654-3665.
87. Isler J.A., Skalet A.H., Alwine J.C. Human cytomegalovirus infection activates and regulates the unfolded protein response. J Virol 2005, 79:6890-6899.
88. Montero H., Rojas M., Arias C.F., Lopez S. Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules. J Virol 2008, 82:1496-1504.
89. Khaperskyy D.A., Hatchette T.F., McCormick C. Influenza A virus inhibits cytoplasmic stress granule formation. Faseb J 2011, 10.1096/fj.11-196915.
90. Smith J.A., Schmechel S.C., Raghavan A., Abelson M., Reilly C., Katze M.G., et al. Reovirus induces and benefits from an integrated cellular stress response. J Virol 2006, 80:2019-2033.
91. Qin Q., Hastings C., Miller C.L. Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection. J Virol 2009, 83:11090-11101.
92. Rathore A.P., Ng M.L., Vasudevan S.G. Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation. Virol J 2013, 10:36.
93. White J.P., Cardenas A.M., Marissen W.E., Lloyd R.E. Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase. Cell Host Microbe 2007, 2:295-305.
94. Emara M.M., Brinton M.A. Interaction of TIA-1/TIAR with West Nile and dengue virus products in infected cells interferes with stress granule formation and processing body assembly. Proc Natl Acad Sci U S A 2007, 104(21):9041-9046.
95. Ward A.M., Bidet K., Yinglin A., Ler S.G., Hogue K., Blackstock W., et al. Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures. RNA Biol 2011, 8:1173-1186.
96. Esclatine A., Taddeo B., Roizman B. The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs. Proc Natl Acad Sci U S A 2004, 101:18165-18170.
97. Legros S., Boxus M., Gatot J.S., Van Lint C., Kruys V., Kettmann R., et al. The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6. Oncogene 2011, 30:4050-4062.
98. Abrahamyan L.G., Chatel-Chaix L., Ajamian L., Milev M.P., Monette A., Clement J.F., et al. Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA. J Cell Sci 2010, 123:369-383.
99. Ariumi Y., Kuroki M., Kushima Y., Osugi K., Hijikata M., Maki M., et al. Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol 2011, 85:6882-6892.
100. Lindquist M.E., Mainou B.A., Dermody T.S., Crowe J.E. Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication. Virology 2011, 413:103-110.
101. Simpson-Holley M., Kedersha N., Dower K., Rubins K.H., Anderson P., Hensley L.E., et al. Formation of antiviral cytoplasmic granules during orthopoxvirus infection. J Virol 2011, 85:1581-1593.