Vascular endothelium: The battlefield of dengue viruses

FEMS Immunology and Medical Microbiology

Volumn 53, Issue 3, 2008, Pages 287-299

  Basu, Atanu ^a   Chaturvedi, Umesh C ^b,c  

^a NATIONAL INSTITUTE OF VIROLOGY   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

^c 201 Annapurna Apartments ^*  (India)

Author keywords

Cytokines; Dengue haemorrhagic fever; Dengue virus; Pathogenesis; Vascular endothelium; Vascular permeability

Indexed keywords

ANTIBODY; CYTOKINE; INTERLEUKIN 8;

ANIMAL CELL; BLOOD VESSEL PERMEABILITY; CAPILLARY ENDOTHELIUM; CELL ACTIVATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENGUE; DENGUE VIRUS; ENDOTHELIUM LESION; HUMAN; HUMAN CELL; IMMUNE COMPLEX DISEASE; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; MEMORY T LYMPHOCYTE; NONHUMAN; PATHOPHYSIOLOGY; PLASMA; PRIORITY JOURNAL; SHORT SURVEY; VASCULAR ENDOTHELIUM; VIRUS STRAIN; VIRUS VIRULENCE;

CAPILLARY PERMEABILITY; DENGUE HEMORRHAGIC FEVER; DENGUE VIRUS; ENDOTHELIUM, VASCULAR; HOST-PATHOGEN INTERACTIONS; HUMANS;

EID: 48449100077     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2008.00420.x     Document Type: Short Survey

References (97)

1. Agarwal R, Chaturvedi UC, Misra A, Mukerjee R, Kapoor S, Nagar R, Tandon R Mathur A (1998) Production of cytotoxic factor by peripheral blood mononuclear cells (PBMC) of the cases of dengue haemorrhagic fever. Clin Exp Immunol 112 : 340 344.
2. Agarwal R, Elbishbishi EA, Chaturvedi UC, Nagar R Mustafa AS (1999) Profile of transforming growth factor-beta1 in patients with dengue haemorrhagic fever. Int J Exp Path 80 : 143 149.
3. Anderson R, Wang S, Osiowy C Issekutz AC (1997) Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. J Virol 71 : 4226 4232.
4. Appanna R, Huat TL, See LL, Tan PL, Vadivelu J Devi S (2007) Cross-reactive T-cell responses to the nonstructural regions of dengue viruses among dengue fever and dengue hemorrhagic fever patients in Malaysia. Clin Vaccine Immunol 14 : 969 977.
5. Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME Lo EH (2001) Effects of matrix metalloproteinase 9 gene knockout on the proteolysis of blood brain barrier and white matter components after cerebral ischaemia. J Neurosci 21 : 7724 7732.
6. Avirutnan P, Malasit P, Seliger B, Bhakdi S Husmann M (1998) Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis. J Immunol 161 : 6338 6346.
7. Avirutnan P, Punyadee N, Noisakran S et al 2006) Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement. J Infect Dis 193 : 1078 1088.
8. Bazzoni G Dijana E (2004) Endothelial cell-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 84 : 860 891.
9. Beaumier CM, Mathew A, Bashyam HS Rothman AL (2008) Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary Dengue virus infections in mice in a sequence-specific manner. J Infect Dis 197 : 608 617.
10. Blum MS, Toninelli E, Anderson JM, Balda MS, Zhou J, O'Donnell L, Pardi R Bender JR (1997) Cytoskeletal rearrangements mediate human microvascular endothelial tight junction modulation by cytokines. Am J Physiol 273 : H286 H294.
11. Bosch I, Xhaja K, Estevez L, Raines G, Melichar H, Warke RV, Fournier MV, Ennis FA Rothman AL (2002) Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge. J Virol 76 : 5588 5597.
12. Bunyaratvej A, Butthep P, Yoksan S Bhamarapravati N (1997) Dengue viruses induce cell proliferation and morphological changes of endothelial cells. Southeast Asian J Trop Med Public Health 28 (suppl 3), 32 37.
13. Cardier JE, Mariño E, Romano E, Taylor P, Liprandi F, Bosch N Rothman AL (2005) Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-alpha in endothelial cell damage in dengue. Cytokine 30 : 359 365.
14. Cardier JE, Rivas B, Romano E, Rothman AL, Perez-Perez C, Ochoa M, Caceres AM, Cardier M, Guevara N Giovannetti R (2006) Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells. Endothelium 13 : 335 340.
15. Carr JM, Hocking H, Bunting K, Wright PJ, Davidson A, Gamble J, Burrell CJ Li P (2003) Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers. J Med Virol 69 : 521 528.
16. Cereijido M, Gonzalez-mariscal L Contreras G (1989) Tight-junction: barrier between higher organisms and environment. News Physiol 4 : 72 75.
17. Chaturvedi UC (1984) Dengue virus-induced suppressor pathway. Curr Sci 53 : 971 976.
18. Chaturvedi UC Shrivastava R (2004) Dengue haemorrhagic fever: a global challenge. Indian J Med Microbiol 22 : 5 6.
19. Chaturvedi UC, Mukerjee R Dhawan R (1994) Active immunization by a dengue virus-induced cytokine. Clin Exp Immunol 96 : 202 207.
20. Chaturvedi UC, Dhawan R Mukerjee R (1997) Immunosuppression and cytotoxicity of dengue infection in the mouse model. Dengue and dengue haemorrhagic Fever (Gubler DJ Kuno G, eds), pp. 291 312. Oxon, UK CAB International Press, Wallingford.
21. Chaturvedi UC, Raghupathy R, Pacsa AS et al 1999a) Shift from a Th1-type response to Th2-type in Dengue haemorrhagic fever. Curr Sci 76 : 63 69.
22. Chaturvedi UC, Agarwal R, Misra A, Mukerjee R, Kapoor S Nagar R (1999b) Cytotoxic factor in dengue haemorrhagic fever. Med Principles Pract 8 : 26 31.
23. Chaturvedi UC, Agarwal R, Elbishbishi EA Mustafa AS (2000) Cytokine cascade in Dengue haemorrhagic fever: implications for pathogenesis. FEMS Immunol Med Microbiol 28 : 183 188.
24. Chaturvedi UC, Elbishbishi EA, Agarwal R Mustafa AS (2001) Cytotoxic factor-autoantibodies: possible role in the pathogenesis of dengue haemorrhagic fever. FEMS Immunol Med Microbiol 30 : 181 186.
25. Chaturvedi UC, Shrivastava R Nagar R (2005) Dengue vaccines: problems and prospects. Indian J Med Res 121 : 639 652.
26. Chaturvedi UC, Nagar R Shrivastava R (2006a) Macrophage and dengue virus: friend or foe? Indian J Med Res 124 : 23 40.
27. Chaturvedi UC, Nagar R Shrivastava R (2006b) Dengue and dengue haemorrhagic fever: implications of host genetics. FEMS Immunol Med Microbiol 47 : 155 166.
28. Chaturvedi UC, Shrivastava R, Tripathi RK Nagar R (2007) Dengue virus-specific suppressor T cells: current perspectives. FEMS Immunol Med Microbiol 50 : 285 299.
29. Chen HC, Hofman FM, Kung JT, Lin YD Wu-Hsieh BA (2007) Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol 81 : 5518 5526.
30. Chungue E, Poli L, Roche C, Gestas P, Glaziou P Markoff LJ (1994) Correlation between detection of plasminogen cross-reactive antibodies and hemorrhage in dengue virus infection. J Infect Dis 170 : 1304 1307.
31. Cines DB, Pollak ES, Buck CA et al 1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91 : 3527 3561.
32. Clark DV, Mammen JRMP, Nisalak A, Pithimethee V Endy TP (2005) Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels. Am J Trop Med Hyg 72 : 786 791.
33. Cologna R, Armstrong PM Rico-Hesse R (2005) Selection for virulent dengue viruses occurs in humans and mosquitoes. J Virol 79 : 853 859.
34. Crone C (1986) Modulation of solute permeability in microvascular endothelium. Fed Proc 45 : 77 83.
35. Dewi B, Takasaki T Kurane I (2004) In vitro assessment of human endothelial cell permeability: effects of inflammatory cytokines and dengue virus infection. J Virol Methods 121 : 171 180.
36. Dewi BE, Takasaki T Kurane I (2008) Peripheral blood mononuclear cells increase the permeability of dengue virus-infected endothelial cells in association with downregulation of vascular endothelial cadherin. J Gen Virol 89 : 642 652.
37. + cytotoxic T lymphocyte clones. J Virol 73 : 3623 3629.
38. Guzmán MG, Kouri G, Bravo J, Valdes L, Vazquez S Halstead SB (2002) Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis 6 : 118 124.
39. Halstead SB (1989) Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenetic cascade. Rev Infect Dis 11 : S830 S839.
40. Halstead SB (2002a) Dengue. Curr Opin Infect Dis 15 : 471 476.
41. Halstead SB (2007) Dengue. Lancet 370 : 1644 1652.
42. Halstead SB, Lan NT, Myint TT et al 2002b) Dengue hemorrhagic fever in infants: research opportunities ignored. Emerg Infect Dis 8 : 1474 1479.
43. Huang YH, Lei HY, Liu HS, Lin YS, Liu CC Yeh TM (2000) Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production. Am J Trop Med Hyg 63 : 71 75.
44. Huang YH, Lei HY, Liu HS, Lin YS, Chen SH, Liu CC Yeh TM (2003) Tissue plasminogen activator induced by dengue virus infection of human endothelial cells. J Med Virol 70 : 610 616.
45. Iglarz M Clozel M (2007) Mechanisms of ET-1-induced endothelial dysfunction. J Cardiovasc Pharmacol 50 : 621 628.
46. Jessie K, Fong MY, Devi S, Lam SK, Thong K Wong KT (2004) Localization of Dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. J Infect Dis 189 : 1411 1418.
47. Jiang L, Guo H Fang D (1999) Effect of dengue virus infection on the production of ET-1 and PGI2 by human vascular endothelial cells. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 13 : 239 242.
48. Jiang Z, Tang X, Xiao R, Jiang L Chen X (2007) Dengue virus regulates the expression of hemostasis-related molecules in human vein endothelial cells. J Infect 55 : 23 28.
49. Jose EC, Marino E, Romano E et al 2005) Proinflammatory factors present in sera from patients with acute dengue infection induced activation and apoptosis of human microvascular endothelial cells: possible role of TNF alpha in endothelial cell damage in dengue. Cytokine 30 : 359 365.
50. Juffrie M, van Der Meer GM, Hack CE, Haasnoot K, Sutaryo VAJ Thijs LG (2000) Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation. Infect Immun 68 : 702 707.
51. Kinglsey J, Liew L Chow VTK (2006) Microarray and real time PCR analysis of a novel set of differentially expressed human geneses in ECV304 endothelial-like cells infected with dengue virus type 2. J Virol Methods 131 : 47 57.
52. Kochel TJ, Watts DM, Halstead SB et al 2002) Neutralization of American genotype dengue 2 viral infection by dengue l antibodies may have prevented dengue hemorrhagic fever in Iquitos, Peru. Lancet 360 : 310 312.
53. Krishnamurti C, Peat RA, Cutting MA Rothwell SW (2002) Platelet adhesion to dengue-2 virus-infected endothelial cells. Am J Trop Med Hyg 66 : 435 441.
54. Lee YR, Liu MT, Lei HY, Liu CC, Wu JM, Tung YC, Lin YS, Yeh TM, Chen SH Liu HS (2006) MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol 87 : 3623 3630.
55. Leitmeyer KC, Vaughn DW, Watts DM, Salas R, Villalobos I, de Chacon RC Rico-Hesse R (1999) Dengue virus structural differences that correlate with pathogenesis. J Virol 73 : 4738 4747.
56. Limonta D, Capó V, Torres G, Pérez AB Guzmán MG (2007) Apoptosis in tissues from fatal dengue shock syndrome. J Clin Virol 40 : 50 54.
57. Lin CF, Lei HY, Shiau AL, Liu HS, Yeh TM, Chen SH, Liu CC, Chiu SC Lin YS (2002) Endothelial cell apoptosis induced by antibodies against Dengue virus nonstructural protein 1 via production of nitric oxide. J Immunol 169 : 657 664.
58. Lin CF, Lei HY, Shiau AL, Liu CC, Liu HS, Yeh TM, Chen SH Lin YS (2003) Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J Med Virol 69 : 82 90.
59. Lin CF, Chiu SC, Hsiao YL et al 2005) Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. J Immunol 174 : 395 403.
60. Lin CF, Wan SW, Cheng HJ, Lei HY Lin YS (2006) Autoimmune pathogenesis in dengue virus infection. Viral Immunol 19 : 127 132.
61. Lin YS, Lin CF, Lei HY, Liu HS, Yeh TM, Chen SH Liu CC (2004) Antibody-mediated endothelial cell damage via nitric oxide. Curr Pharm Des 10 : 213 221.
62. Lugus JJ, Park C Choi K (2005) Developmental relationship between hematopoietic and endothelial cells. Immunol Res 32 : 57 74.
63. Luplertlop N, Missé D, Bray D, Deleuze V, Gonzalez JP, Leardkamolkarn V, Yssel H Veas F (2006) Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction. EMBO Rep 7 : 1176 1181.
64. + T cells to heterologous serotypes. J Immunol 175 : 2676 2683.
65. Medin CL Rothman AL (2006) Cell type-specific mechanisms of interleukin-8 induction by dengue virus and differential response to drug treatment. J Infect Dis 193 : 1070 1077.
66. Medin CL, Fitzgerald KA Rothman AL (2005) Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion. J Virol 79 : 11053 11061.
67. Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL Dragic T (2008) The tight junction proteins claudin-1, -6 and -9 are entry cofactors for the Hepatitis C virus. J Virol 82 : 3555 3560.
68. Miller-Kasprzak E Jagodziński PP (2007) Endothelial progenitor cells as a new agent contributing to vascular repair. Arch Immunol Ther Exp (Warsz) 55 : 247 259.
69. Misra A, Mukerjee R Chaturvedi UC (1996a) Production of nitrite by dengue virus-induced cytotoxic factor. Clin Exp Immunol 104 : 650 655.
70. Misra A, Mukerjee R Chaturvedi UC (1996b) Release of reactive oxygen intermediates by dengue virus-induced macrophage cytotoxin. Int J Exp Pathol 77 : 237 242.
71. Misra A, Mukerjee R Chaturvedi UC (1998) Respiratory burst by dengue virus-induced cytotoxic factor. Med Principles Pract 7 : 251 260.
72. Mongkolsapaya J, Dejnirattisai W Xu XN (2003) Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med 9 : 921 927.
73. Mongkolsapaya J, Duangchinda T, Dejnirattisai W, Vasanawathana S, Avirutnan P Jairungsri A (2006) T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal? J Immunol 176 : 3821 3829.
74. Mukerjee R, Misra A Chaturvedi UC (1996) Dengue virus-induced cytotoxin releases nitrite by spleen cells. Int J Exp Pathol 77 : 45 51.
75. Mukerjee R, Chaturvedi UC, Vaughn DW Kalayanarooj S (1997) Purification and pathogenicity of the cytotoxic factor from the cases of dengue haemorrhagic fever. Curr Sci 72 : 494 501.
76. Myint KS, Endy TP, Mongkolsirichaikul D et al 2006) Apoptosis is an important modulator of cellular immune responses during systemic viral infections. J Infect Dis 194 : 600 607.
77. Neves-Souza PC, Azeredo EL, Zagne SM, Valls-de-Souza R, Reis SR, Cerqueira DI, Nogueira RM Kubelka CF (2005) Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue fever in patients and during in vitro infection. BMC Infect Dis 5 : 64 69.
78. Nguyen TH, Lei HY, Nguyen TL, Lin YS, Huang KJ, Le BL Lin CF (2004) Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis 189 : 221 232.
79. Pacsa AS, Agarwal R, Elbishbishi EA, Chaturvedi UC, Nagar R Mustafa AS (2000) Interleukin-12 in patients with dengue haemorrhagic fever. FEMS Immunol Med Microbiol 28 : 151 155.
80. Raghupathy R, Chaturvedi UC, Al-Sayer H, Elbishbishi EA, Agarwal R, Nagar R, Nusrat H, Mustafa AS, Azizieh F Khan MAY (1998) Elevated levels of IL-8 in dengue hemorrhagic fever. J Med Virol 56 : 280 285.
81. Risau W Flamme I (1995) Vasculogenesis. Annu Rev Cell Dev Biol 11 : 73 91.
82. Rodriguez-Ortega M (1998) Nitric oxide in dengue pathology. Acta Cient Venez 49 (suppl 1), 8 12.
83. Sahaphong S, Riengrojpitak S, Bhamarapravati N Chirachariyavej T (1980) Electron microscopic study of the vascular endothelial cell in dengue hemorrhagic fever. Southeast Asian J Trop Med Public Health 11 : 194 204.
84. Sierra B, Garcia G, Perez AB, Morier L, Rodriguez R, Alvarez M Guzman MG (2002) Long-term memory cellular immune response to dengue virus after a natural primary infection. Int J Infect Dis 6 : 125 128.
85. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, Ennis FA Rothman AL (2007) Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic fever. J Virol 81 : 1592 600.
86. Stephenson JR (2005) Understanding dengue pathogenesis: implications for vaccine design. Bull World Health Organ 83 : 308 314.
87. Talavera D, Castillo AM, Dominguez MC, Gutierrez AE Meza I (2004) IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers. J Gen Virol 85 : 1801 1813.
88. Theofilopoulos AN, Wilson CB Dixon FJ (1976) The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 57 : 169 182.
89. Warke RV, Xhaja K, Martin KJ et al 2003) Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. J Virol 77 : 11822 11832.
90. Warke RV, Martin KJ, Giaya K, Shaw SK, Rothman AL Bosch I (2008) TRAIL is a novel anti-viral protein against dengue virus. J Virol 82 : 555 564.
91. Watts DM, Porter KR, Putvatana P et al 1999) Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever. Lancet 354 : 1431 1434.
92. Wei HY, Jiang LF, Fang DY Guo HY (2003) Dengue virus type 2 infects human endothelial cells through binding of the viral envelope glycoprotein to cell surface polypeptides. J Gen Virol 84 : 3095 3098.
93. Wiedmer T, Zhou Q, Kwoh DY Sims PJ (2000) Identification of three new members of the phospholipid scramblase gene family. Biochim Biophysics Acta 1467 : 244 253.
94. Yao HY, Liu B Mao N (2007) Relationship between hematopoietic development and endothelial cells (hemangioblast or hemogenic endothelium) - review. Zhongguo Shi Yan Xue Ye Xue Za Zhi 15 : 198 201.
95. Yu HS, Wang MT, Tai CL, Yang SA Chien CH (1989) Skin eruption and histopathological changes in dengue fever. Gaoxiong Yi Xue Ke Xue Za Zhi 5 : 17 23.
96. Yuan SY (2006) New insights into eNOS signaling in microvascular permeability. Am J Physiol Heart Circ Physiol 291 : H1029 H1031.
97. Zhang JL, Wang JL, Gao N, Chen ZT, Tian YP An J (2007) Up-regulated expression of beta3 integrin induced by dengue virus serotype 2 infection associated with virus entry into human dermal microvascular endothelial cells. Biochem Biophys Res Commun 356 : 763 768.