Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms

Journal of Virology

Volumn 80, Issue 12, 2006, Pages 6061-6071

  Berkova, Z ^a,b   Crawford, S E ^a   Trugnan, G ^c   Yoshimori, T ^d   Morris, A P ^b   Estes, M K ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c HÔPITAL SAINT ANTOINE   (France)

^d NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; CALCIUM; ENHANCED GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MESSENGER RNA; ROTAVIRUS NONSTRUCTURAL PROTEIN 4; SMALL INTERFERING RNA; VIRUS PROTEIN;

ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENDOPLASMIC RETICULUM; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; PATHOGENESIS; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA REPLICATION; RNA SYNTHESIS; ROTAVIRUS; VIRAL GASTROENTERITIS; VIRUS MORPHOGENESIS; VIRUS REPLICATION;

CALCIUM; CELL COMPARTMENTATION; CELL LINE; CYTOPLASMIC VESICLES; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; HUMANS; PROTEIN TRANSPORT; ROTAVIRUS; ROTAVIRUS INFECTIONS; TOXINS, BIOLOGICAL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

ROTAVIRUS;

EID: 33744935521     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02167-05     Document Type: Article

References (32)

1. Au, K. S., W. K. Chan, J. W. Burns, and M. K. Estes. 1989. Receptor activity of rotavirus nonstructural glycoprotein NS28. J. Virol. 63:4553-4562.
2. Au, K. S., N. M. Mattion, and M. K. Estes. 1993. A subviral particle binding domain on the rotavirus nonstructural glycoprotein NS28. Virology 194:665-673.
3. Ball, J. M., P. Tian, C. Q. Zeng, A. P. Morris, and M. K. Estes. 1996. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science 272:101-104.
4. Ball, J., D. M. Mitchell, T. F. Gibbons, and R. D. Parr. 2005. Rotavirus NSP4: a multifunctional viral enterotoxin. Viral Immunol. 18:27-40.
5. Berkova, Z., A. P. Morris, and M. K. Estes. 2003. Cytoplasmic calcium measurement in rotavirus enterotoxin-enhanced green fluorescent protein (NSP4-EGFP) expressing cells loaded with Fura-2. Cell Calcium 34:55-68.
6. Both, G. W., J. S. Mattick, and A. R. Bellamy. 1983. Serotype-specific glycoprotein of simian 11 rotavirus: coding assignment and gene sequence. Proc. Natl. Acad. Sci. USA 80:3091-3095.
7. Brostrom, M. A., and C. O. Brostrom. 2003. Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: implications for cell growth and adaptability. Cell Calcium 34:345-363.
8. Dong, Y., C. Q. Zeng, J. M. Ball, M. K. Estes, and A. P. Morris. 1997. The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production. Proc. Natl. Acad. Sci. USA 94:3960-3965.
9. Ericson, B. L., D. Y. Graham, B. B. Mason, H. H. Hanssen, and M. K. Estes. 1983. Two types of glycoprotein precursors are produced by the simian rotavirus SA11 Virology 127:320-332.
10. Estes, M. K., E. L. Palmer, and J. F. Objeski. 1983. Rotaviruses: a review. Curr. Top. Microbiol. Immunol. 105:124-184.
11. Estes, M. K., G. Kang, C. Q.-Y. Zeng, S. E. Crawford, and M. Ciarlet. 2001. Pathogenesis of rotavirus gastroenteritis. In D. Chadwick and J. Goode (ed.), Gastroenteritis viruses. Novartis Found. Symp. 238:82-100.
12. Fabbretti, E., I. Afrikanova, F. Vascotto, and O. R. Burrone. 1999. Two non-structural rotavirus proteins. NSP2 and NSP5, form viroplasm-like structures in vivo. J. Gen. Virol. 80:333-339.
13. Gonzàles, R. A., R. Espinosa, P. Romero, S. López, and C. F. Arias. 2000. Relative localization of viroplasmic end endoplasmic reticulum-resident rotavirus proteins in infected cells. Arch. Virol. 145:1963-1973.
14. Haughland, R. P. 1996. Handbook of fluorescent probes and research chemicals, 6th ed. Molecular Probes, Eugene. Ore.
15. Jackson, W. T., T. H. Giddings, Jr., M. P. Taylor, S. Mulinayawe, M. Rabinovitch, R. R. Kopito, and K. Kirkegaard. 2005. Subversion of cellular autophagosomal machinery by RNA viruses. PLOS Biol. 3:861-871.
16. Kabeya, Y., N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, E. Kominami, Y. Ohsumi, and T. Yoshimori. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720-5728.
17. Klionsky, D. J., and S. D. Emr. 2000. Autophagy as a regulated pathway of cellular degradation. Science 290:1717-1721.
18. López, T., M. Camacho, M. Zayas, R. Nájera, R. Sánchez, C. F. Arias, and S. López. 2005. Silencing the morphogenesis of rotavirus. J. Virol. 79:184-192.
19. Mann, S. S., and J. A. Hammarback. 1994. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J. Biol. Chem. 269:11492-11497.
20. Meyer, J. C., C. C. Bergmann, and A. R. Bellamy. 1989. Interaction of rotavirus cores with the nonstructural glycoprotein NS28. Virology 171:98-107.
21. Michelangeli, F., M. C. Ruiz, J. R. del Castillo, J. E. Ludert, and F. Liprandi. 1991. Effect of rotavirus infection on intracellular calcium homeostasis in cultured cells. Virology 181:520-527.
22. (2+)mediated I(-) influx into intestinal crypts of CF mice. Am. J. Physiol. 277:G431-G444.
23. Prentice, E., W. G. Jerome, T. Yoshimori, N. Mizushima, and M. R. Denison. 2004. Coronavirus replication complex formation utilizes components of cellular macrophagy. J. Cell Biol. 279:10136-10141.
24. Schlegel, A., T. H. Giddings, Jr., M. S. Ladinsky, and K. Kirkegaard. 1996. Cellular origin and ultrastructure of membranes induced during poliovirus infection. J. Virol. 70:6576-6588.
25. Silvestri, L. S., Z. R. Taraporewala, and J. T. Patton. 2004. Rotavirus replication: plus-sense templates for double-stranded RNA synthesis are made in viroplasms. J. Virol. 78:7763-7774.
26. Silvestri, L. S., M. A. Tortorici, R. Vasquez-DelCaprio, and J. T. Patton. 2005. The rotavirus glycoprotein NSP4 is a modulator of viral transcription in the infected cell. J. Virol., in press.
27. Suhy, D. A., T. H. Giddings, Jr., and K. Kirkegaard. 2000. Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles. J. Virol. 74:8953-8965.
28. Tian, P., A. Ottaiano, P. A. Reilly, S. Udem, and T. Zamb. 2000. The authentic sequence of rotavirus SA11 nonstructural protein NSP4. Virus Res. 66:117-122.
29. Welch, W. S. K., S. E. Crawford, and M. K. Estes. 1989. Rotavirus SA11 genome segment 11 protein is a nonstructural phosphoprotein. J. Virol. 63:3974-3982.
30. Xu, A., A. R. Bellamy, and J. A. Taylor. 1998. BiP (GRP78) and endoplasmin (GRP94) are induced following rotavirus infection and bind transiently to an endoplasmic reticulum-localized virion component. J. Virol. 72:9865-9872.
31. Xu, A., A. R. Bellamy, and J. A. Taylor. 2000. Immobilization of the early secretory pathway by a virus glycoprotein that binds to microtubules. EMBO J. 19:6465-6474.
32. Zhang, M., C. Q. Zeng, A. P. Morris, and M. K. Estes. 2000. A functional NSP4 enterotoxin peptide secreted from rotavirus-infected cells. J. Virol. 74:11663-11670.