Molecular aspects of Dengue virus replication

Future Microbiology

Volumn 3, Issue 2, 2008, Pages 155-165

  Bartenschlager, Ralf ^a   Miller, Sven ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

Cyclization sequence; Dengue virus; Double membrane vesicles; Membrane rearrangements; Nonstructural proteins; Nuclear localization; Polyprotein; Replication; Replication complex; Untranslated region

Indexed keywords

VIRUS PROTEIN; VIRUS RNA;

CELL NUCLEUS; CYTOPLASM; DENGUE; DENGUE VIRUS; GENOME ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA INTERFERENCE; RNA REPLICATION; VIRAL GENETICS; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS TRANSMISSION;

DENGUE VIRUS; GENOME, VIRAL; MODELS, BIOLOGICAL; VIRUS REPLICATION;

DENGUE VIRUS;

EID: 47249142841     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460913.3.2.155     Document Type: Review

References (73)

1. Gubler DJ: Epidemic Dengue/Dengue hemorrhagic fever as a public health, social and economic problem in the 21st Century. Trends Macrobiol. 10, 100-103 (2002).
2. Mackenzie JS, Gubler Dj, Petersen LR: Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and Dengue viruses. Nat. Med. 10, S98-S109 (2004).
3. Cleaves GR, Dubin DT. Methylation status of intracellular Dengue type 2 40 S RNA. Virology 96, 159-165 (1979).
4. Clyde K, Kyle JL, Harris E: Recent advances in deciphering viral and host determinants of Dengue virus replication and pathogenesis. J. Virol. 80, 11418-11431 (2006).
5. Halstead SB: Dengue. Lancet 370, 1644-1652 (2007).
6. Rico-Hesse R: Microevolution and virulence of Dengue viruses. Adv. Virus Res. 59, 315-341 (2003).
7. Weaver SC, Barrett AD: Transmission cycles, host range, evolution and emergence of arboviral disease. Nat. Rev. Microbiol. 2, 789-801 (2004).
8. Whitehead SS, Blaney JE, Durbin AP, Murphy BR: Prospects for a Dengue virus vaccine. Nat. Rev. Microbiol. 5, 518-528 (2007).
9. Anderson R: Manipulation of cell surface macromolecules by flavivinises. Adv. Virus Res. 59, 229-274 (2003).
10. Chen YC, Wang SY, King CC: Bacterial lipopolysaccharide inhibits Dengue virus infection of primary human monocytes/macrophages by blockade of virus entry via a CD14-dependent mechanism. J. Virol. 73, 2650-2657 (1999).
11. Jindadamrongwech S, Thepparit C, Smith DR: Identification of GRP 78 (BiP) as a liver cell expressed receptor element for Dengue virus serotype 2. Arch. Virol. 149, 915-927 (2004).
12. Lozach PY, Burleigh L, Staropoli I et al.: Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of Dengue virus infection is independent of DC-SIGN internalization signals. J. Biol. Chem. 280, 23698-23708 (2005).
13. Navarro-Sanchez E, Altmeyer R, Amara A et al.: Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived Dengue viruses. EMBO Rep. 4, 723-728 (2003).
14. Reyes-Del Valle J, Chavez-Salinas S, Medina F, Del Angel RM: Heat shock protein 90 and heat shock protein 70 are components of Dengue virus receptor complex in human cells. J. Virol. 79, 4557-4567 (2005).
15. Salas-Benito J, Valle JR, Salas-Benito M, Ceballos-Olvera I, Mosso C, Del Angel RM: Evidence that the 45-kD glycoprotein, part of a putative Dengue virus receptor complex in the mosquito cell line C6/36, is a heat-shock related protein. Am. J. Trop. Med. Hyg. 77, 283-290 (2007).
16. Thepparit C, Smith DR: Serotype-specific entry of Dengue virus into liver cells: identification of the 37-kilodalton/67-kilodation high-affinity laminin receptor as a Dengue virus serotype 1 receptor. J. Virol. 78, 12647-12656 (2004).
17. Cahour A, Pletnev A, Vazielle-Falcoz M, Rosen L, Lai CJ: Growth-restricted Dengue virus mutants containing deletions in the 5′ noncoding region of the RNA genome. Virology 207, 68-76 (1995).
18. Deas TS, Binduga-Gajewska I, Tilgner M et al.: Inhibition of flavivirus Infections by antisense oligomers specifically suppressing viral translation and RNA replication. J. Virol. 79, 4599-4609 (2005).
19. Kinney RM, Huang CY, Raw BC et al.: Inhibition of Dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers. J. Virol. 79, 5116-5128 (2005).
20. Yu L, Markoff L: The topology of bulges in the long stem of the flavivirus 3′ stem-loop is a major determinant of RNA replication competence. J. Virol. 79, 2309-2324 (2005).
21. Alvarez DE, Lodeiro, MF, Luduena SJ, Pietrasanta LI, Gamarnik AV: Long-range RNA-RNA interactions circularize the Dengue virus genome. J. Virus. 79, 6631-6643 (2005).
22. Khromykh AA, Meka H, Guyatt KJ, Westaway EG: Essential role of cyclization sequences in flavivirus RNA replication. J. Virol. 75, 6719-6728 (2001).
23. Men R, Bray M, Clark D, Chanock RM, Lai CJ: Dengue type 4 virus mutants containing deletions in the 3′ noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys. J. Virol. 70, 3930-3937 (1996).
24. Tajima S, Nukui Y, Ito M, Takasaki T, Kurane I: Nineteen nucleotides in the variable region of 3′ non-translated region are dispensable for the replication of Dengue type 1 virus in vitro. Virus Res. 116, 38-44 (2006).
25. Leitmeyer KC, Vaughn DW, Watts DM et al.: Dengue virus structural differences that correlate with pathogenesis. J. Virol. 73, 4738-4747 (1999).
26. Amberg SM, Nestorowicz A, McCourt DW, Rice CM: NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies. J. Virol. 68, 3794-3802 (1994).
27. Cahour A, Falgout B, Lai CJ: Cleavage of the Dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease. J. Virol. 66, 1535-1542 (1992).
28. Falgout B, Pethel M, Zhang YM, Lai CJ: Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of Dengue virus nonstructural proteins. J Virol. 65, 2467-2475 (1991).
29. Zhang L, Mohan PM, Padmanabhan R: Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5. J. Virol. 66, 7549-7554 (1992).
30. Egloff MP, Benarroch D, Selisko B, Romette JL, Canard B: An RNA cap (nucleoside-2′-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. Embo. J. 21, 2757-2768 (2002).
31. Egloff MP, Decroly E, Malet H et al.: Structural and functional analysis of methylation and 5′-RNA sequence requirements of short capped RNAs by the methyltransferase domain of Dengue virus NS5. J. Mol. Biol. 372(3), 723-736 (2007).
32. Nomaguchi M, Ackermann M, Yon C, You S, Padmanabhan R: De nova synthesis of negative-strand RNA by Dengue virus RNA-dependent RNA polymerase in vitro. nucleotide, primer, and template parameters. J Virol. 77, 8831-8842 (2003).
33. Tan BH, Fu J, Sugrue RJ, Yap EH, Chan YC, Tan YH: Recombinant Dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity. Virology 216, 317-325 (1996).
34. Bartelma G, Padmanabhan R: Expression, purification, and characterization of the RNA 5′-triphosphatase activity of Dengue virus type 2 nonstructural protein 3. Virology 299, 122-132 (2002).
35. Gorbalenya AE, Donchenko AP, Koonin EV, Blinov VM: N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases. Nucleic Acids Res. 17, 3889-3897 (1989).
36. Gorbalenya AE, Koonin EV, Donchenko AP, Blinov VM: Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res. 17, 4713-4730 (1989).
37. Li H, Clum S, You S, Ebner KE, Padmanabhan R: The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of Dengue virus type 2 NS3 converge within a region of 20 amino acids. J Virol. 73, 3108-3116 (1999).
38. Warrener P, Tamura JK, Collett MS: RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. J Virol. 67, 989-996 (1993).
39. Wengler G: The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity. Virology 197, 265-273 (1993).
40. Lindenbach BD, Rice CM: Trans-complementation of yellow fever virus NS1 reveals a role in early RNA replication. J. Virol. 71, 9608-9617 (1997).
41. Lindenbach BD, Rice CM: Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function. J Virol. 73, 4611-4621 (1999).
42. Muylaert IR, Galler R, Rice CM: Genetic analysis of the yellow fever virus NS1 protein: identification of a temperature-sensitive mutation which blocks RNA accumulation. J. Virol. 71, 291-298 (1997).
43. Falconar AK: The Dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis. Arch. Virol. 142, 897-916 (1997).
44. Chambers TJ, McCourt DW, Rice CM: Yellow fever virus proteins NS2A, NS2B, and NS4B: identification and partial N-terminal amino acid sequence analysis. Virology 169, 100-109 (1989).
45. Munoz-Jordan JL, Laurent-Rolle M, Ashour J et al.: Inhibition of α/β interferon signaling by the NS4B protein of flaviviruses. J. Virol. 79, 8004-8013 (2005).
46. Munoz-Jordan JL, Sanchez-Burgos GG, Laurent-Rolle M, Garcia-Sastre A: Inhibition of interferon signaling by Dengue virus. Proc. Natl Acad Sci. USA 100, 14333-14338 (2003).
47. Miller S, Kastner S, Krijnse-Locker J, Buhler S, Bartenschlager R: The non-structural protein 4A of Dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. J. Biol. Chem. 282, 8873-8882 (2007).
48. Roosendaal J, Westaway EG, Khrormykh A, Mackenzie JM: Regulated cleavages at the West Nile virus NS4A-2K-NS4B junctions play a major role In rearranging cytoplasmic membranes and golgi trafficking of the NS4A protein. J. Virol. 80, 4623-4632 (2006).
49. Miller S, Sparacio, S, Bartenschlager R: Subcellular localization and membrane topology of the Dengue virus type 2 non-structural protein 4B. J. Biol. Chem. 281(13), 8854 (2006).
50. Umareddy I, Chao A, Sampath A, Gu F, Vasudevan SG: Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. J. Gen. Virol. 87, 2605-2614 (2006).
51. Travanty EA, Adelman ZN, Franz AW et al.: Using RNA interference to develop Dengue virus resistance in genetically modified Aedes aegypti. Insect Biochem. Mol. Biol. 34, 607-613 (2004).
52. Mackenzie J: Wrapping things up about virus RNA replication. Traffic 6, 967-977 (2005).
53. Westaway EG, Mackenzie JM, Khromykh AA: Kunjin RNA replication and applications of Kunjin replicons. Adv. Virus Res. 59, 99-140 (2003).
54. Mackenzie JM, Jones MK, Young PR: Improved membrane preservation of flavivirus-infected cells with cryosectioning. J. Virol. Metbods 56, 67-75 (1996).
55. Hahn CS, Hahn YS, Rice CM et al.: Conserved elements in the 3′ untranslated region of flavivirus RNAs and potential cyclization sequences. J. Mol. Biol. 198, 33-41 (1987).
56. You S, Falgout B, Markoff L, Padmanabhan R: In vitro RNA synthesis from exogenous Dengue viral RNA templates requires long range interactions between 5′- and 3′-terminal regions that influence RNA structure. J. Biol. Chem. 276, 15581-15591 (2001).
57. Filomatori CV, Lodeiro MF, Alvarez DE, Samsa MM, Pietrasanta L, Gamarnik AV: A 5′ RNA element promotes Dengue virus RNA synthesis on a circular genome. Genes Dev. 20, 2238-2249 (2006).
58. Blackwell JL, Brinton MA: Translation elongation factor-1 α interacts with the 3′ stem-loop region of West Nile virus genomic RNA. J. Virol. 71, 6433-6444 (1997).
59. Chiou CT, Hu CC, Chen PH, Liao CL, Lin YL, Wang JJ: Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein. J. Gen. Virol. 84, 2795-2805 (2003).
60. Yocupicio-Monroy M, Padmanabhan R, Medina F, Del Angel R: Mosquito La protein binds to the 3′ untranslated region of the positive and negative polarity Dengue virus RNAs and relocates to the cytoplasm of infected cells. Virology 357, 29-40 (2007).
61. Chu JJ, Yang PL: c-Src protein kinase inhibitors block assembly and maturation of Dengue virus. Proc. Natl Acad Sci. USA 104, 3520-3525 (2007).
62. Kapoor M, Zhang L, Ramachandra M, Kusukawa J, Ebner KE, Padmanabhan R: Association between NS3 and NS5 proteins of Dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J. Biol. Chem. 270, 19100-19106 (1995).
63. Buckley A, Gaidamovich S, Turchinskaya A, Gould EA: Monoclonal antibodies identify the NS5 yellow fever virus non-structural protein in the nuclei of infected cells. J. Gen. Virol. 73(Pt 5), 1125-1130 (1992).
64. Jans DA, Xiao CY, Lam MH: Nuclear targeting signal recognition: a key control point in nuclear transport? Bioessays 22, 532-544 (2000).
65. Brooks AJ, Johansson M, John AV, Xu Y, Jans DA, Vasudevan SG: The interdomain region of Dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin β 1 and importin α/β-recognized nuclear localization signals. J. Biol. Chem. 277, 36399-36407 (2002).
66. Pryor MJ, Rawlinson SM, Wright PJ, Jans DA: CRM1-dependent nuclear export of Dengue virus type 2 NS5. Novartis Found Symp. 277, 149-161; discussion 161-163, 251-253 (2006).
67. Pryor MJ, Rawlinson SM, Butcher RE et al.: Nuclear localization of Dengue virus nonstructural protein 5 through its importin α/ β-recognized nuclear localization sequences is integral to viral infection. Traffic 8, 795-807 (2007).
68. Bulich R, Aaskov JG: Nuclear localization of Dengue 2 virus core protein detected with monoclonal antibodies. J. Gen. Virol. 73(Pt 11), 2999-3003 (1992).
69. Tadano M, Makino Y, Fukunaga T, Okuno Y, Fukai K: Detection of Dengue 4 virus core protein in the nucleus. I. A monoclonal antibody to Dengue 4 virus reacts with the antigen in the nucleus and cytoplasm. J. Gen. Virol. 70 (Pt 6), 1409-1415 (1989).
70. Tsuda Y, Mori Y, Abe T et al.: Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication. Microbiol. Immunol. 50, 225-234 (2006).
71. Wang SH, Syu WJ, Huang KJ et al.: Intracellular localization and determination of a nuclear localization signal of the core protein of Dengue virus. J. Gen. Virol. 83, 3093-3102 (2002).
72. Chang CJ, Luh HW, Wang SH, Lin HJ, Lee SC, Hu ST: The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts with Dengue virus core protein. DNA Cell Biol. 20, 569-577 (2001).
73. Uchil PD, Kumar AV, Satchidanandam V: Nuclear localization of flavivirus RNA synthesis in infected cells. J. Virol. 80, 5451-5464 (2006).