Synthesis and biological activity of 4-aryl-3-benzoyl-5- phenylspiro[pyrrolidine-2.3′-indolin]-2′-one derivatives as novel potent inhibitors of advanced glycation end product

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 282-289

  Kaur, Anjandeep ^a   Singh, Baldev ^a   Vyas, Bhawna ^a   Silakari, Om ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

Antiglycation; Azomethine ylide; Cycloaddition; Pyrrolidine; Stereoselective

Indexed keywords

4 ARYL 3 BENZOYL 5 PHENYLSPIRO [PYRROLIDINE 2.3' INDOLIN] 2' ONE DERIVATIVE; ADVANCED GLYCATION END PRODUCT; ANTIDIABETIC AGENT; AZOMETHINE YLIDE; BOVINE SERUM ALBUMIN; ISATIN; SPIROINDOLONE PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; PYRROLIDINE DERIVATIVE; SPIRO COMPOUND;

ANTIDIABETIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CYCLOADDITION; DRUG SYNTHESIS; GLUCOSE ASSAY; HUMAN; HUMAN CELL; STEREOCHEMISTRY; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINAE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; QUANTUM THEORY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSYLATION END PRODUCTS, ADVANCED; INDOLES; MOLECULAR STRUCTURE; PYRROLIDINES; QUANTUM THEORY; SERUM ALBUMIN, BOVINE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898878084     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.022     Document Type: Article

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