Inhibition of protein glycation by urea and thiourea derivatives of glycine/proline conjugated benzisoxazole analogue-Synthesis and structure-activity studies

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 325-332

  Shantharam, C S ^a   Suyoga Vardhan, D M ^a   Suhas, R ^a   Sridhara, M B ^a   Gowda, D Channe ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

Amino acids; Antiglycation; Conjugation; Urea thiourea

Indexed keywords

1 (2 BROMOPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL]THIOUREA; 1 (3 BROMOPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL]THIOUREA; 1 (3 BROMOPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL]UREA; 1 (3 CHLOROPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOPHENYL]THIOUREA; 1 (3 CHLOROPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN1 YL] 2 OXOETHYL]UREA; 1 (4 BROMOPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL]UREA; 1 (4 CHLOROPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL]THIOUREA; 1 (4 CHLOROPHENYL) 3 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL]UREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (2 FLUOROPHENYL)THIOUREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (2 FLUOROPHENYL)UREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (2 METHOXYPHENYL)THIOUREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (2 METHOXYPHENYL)UREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (3 FLUOROPHENYL)UREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (3 METHOXYPHENYL)THIOUREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (3 METHOXYPHENYL)UREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (4 FLUOROPHENYL)UREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (4 METHOXYPHENYL)THIOUREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 (4 METHOXYPHENYL)UREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 PHENYLTHIOUREA; 1 [2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDIN 1 YL] 2 OXOETHYL] 3 PHENYLUREA; 2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDINE 1 CARBONYL] N PHENYLPYRROLIDINE 1 CARBOTHIOAMIDE; 2 [4 (6 FLUOROBENZO[D]ISOXAZOL 3 YL)PIPERIDINE 1 CARBONYL] N PHENYLPYRROLIDINE 1 CARBOXAMIDE; GLYCINE; ISOXAZOLE DERIVATIVE; PROLINE; RUTOSIDE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ARTICLE; DRUG CONJUGATION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INFRARED SPECTROMETRY; OXIDATION; PROTEIN GLYCOSYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCINE; ISOXAZOLES; MOLECULAR STRUCTURE; PROLINE; SERUM ALBUMIN, BOVINE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84872105782     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.029     Document Type: Article

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