Quantitative structure and aldose reductase inhibitory activity relationship of 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3′- pyrrolidine-1,2′,3,5′-tetrone derivatives

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 5, 2005, Pages 1445-1452

  Ko, Kwangseok ^a   Won, Youngdo ^a  

^a Hanyang University   (South Korea)

Author keywords

Aldose reductase inhibitor; Genetic function approximation; Physicochemical descriptor; QSAR

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; BENZYL DERIVATIVE; PYRAZINE DERIVATIVE; PYRROLIDINE DERIVATIVE;

ARTICLE; CHIRALITY; ENANTIOMER; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 13444261078     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.12.034     Document Type: Article

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