Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry

Drug Metabolism and Disposition

Volumn 40, Issue 7, 2012, Pages 1389-1396

  Sato, Yuichiro ^a   Miyashita, Aiji ^a   Iwatsubo, Takafumi ^a   Usui, Takashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; CARBOXYLESTERASE; CARBOXYLESTERASE 1; CARBOXYLESTERASE 2; CLOPIDOGREL; IRINOTECAN; OXYBUTYNIN; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; CONTROLLED STUDY; CYTOSOL; DRUG HYDROLYSIS; ENZYME ANALYSIS; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPRODUCIBILITY; SAMPLE; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANIMALS; CALIBRATION; CARBOXYLIC ESTER HYDROLASES; CATTLE; CHROMATOGRAPHY, LIQUID; CYTOSOL; HUMANS; HYDROLYSIS; ISOTOPE LABELING; LIVER; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; REPRODUCIBILITY OF RESULTS; SERUM ALBUMIN, BOVINE; TANDEM MASS SPECTROMETRY;

EID: 84862670320     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.045054     Document Type: Article

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