Proximal tubule toll-like receptor 4 expression linked to inflammation and apoptosis following hypoxia/reoxygenation injury

American Journal of Nephrology

Volumn 39, Issue 4, 2014, Pages 337-347

  Liu, Xiu Juan ^a,c   Tan, Yan ^a   Geng, Yan Qiu ^b   Wang, Zhen ^c   Ye, Jun Hong ^c   Yin, Xiu Ying ^c   Fu, Bo ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b GENERAL HOSPITAL OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^c The 94th Hospital of PLA   (China)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Inflammation; Mitochondria; Proximal tubule epithelial cell; Renal hypoxia reoxygenation injury; Toll like receptor 4

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 8; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; DEATH RECEPTOR; TLR4 PROTEIN, RAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HYPOXIA; IN VIVO STUDY; INFLAMMATION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; REOXYGENATION; REPERFUSION INJURY; UPREGULATION; ACUTE KIDNEY FAILURE; ANIMAL; ANOXIA; CELL CULTURE; EPITHELIUM CELL; METABOLISM; NEPHRITIS; PHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT; ANIMAL EXPERIMENT; ANIMAL MODEL;

ACUTE KIDNEY INJURY; ANIMALS; ANOXIA; APOPTOSIS; CELLS, CULTURED; EPITHELIAL CELLS; KIDNEY TUBULES, PROXIMAL; MALE; MITOCHONDRIA; NEPHRITIS; RATS, WISTAR; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84898672741     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000360549     Document Type: Article

References (30)

1. Bonventre J: Pathophysiology of acute kidney injury: Roles of potential inhibitors of inflammation. Contrib Nephrol. Basel, Karger, 2007, vol 156, pp 39-46
2. Mkaddem SB, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, Goujon JM, Ogier-Denis E, Vandewalle A: Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-Activated apoptosis during renal ischemia/reperfusion injury. Cell Death Differ 2010; 17: 1474-1485
3. Kezic A, Thaiss F, Becker JU, Tsui TY, Bajcetic M: Effects of everolimus on oxidative stress in kidney model of ischemia/reperfusion injury. Am J Nephrol 2010; 37: 291-301
4. Wu H, Chen G, Wyburn KR, Yin J, Bertolino P, Eris JM, Alexander SI, Sharland AF, Chadban SJ: TLR4 activation mediates kidney ischemia/ reperfusion injury. J Clin Invest 2007; 117: 2847-2859
5. Rusai K, Sollinger D, Baumann M, Wagner B, Strobl M, Schmaderer C, Roos M, Kirschning C, Heemann U, Lutz J: Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Pediatr Nephrol 2010; 25: 853-860
6. Robson MG: Toll-like receptors and renal disease. Nephron Exp Nephrol 2009; 113:e1-e7
7. Padanilam BJ: Cell death induced by acute renal injury: A perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol 2003; 284:F608-F627
8. Wilson NS, Dixit V, Ashkenazi A: Death receptor signal transducers: Nodes of coordination in immune signaling networks. Nat Immunol 2009; 10: 348-355
9. Woo CW, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald KA, Ron D, Tabas I: Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by Toll-like receptor signalling. Nat Cell Biol 2009; 11: 1473-1480
10. Yeh CH, Hsu SP, Yang CC, Chien CT, Wang NP: Hypoxic preconditioning reinforces HIF-Alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy. Life Sci 2010; 86: 115-123
11. Wang Y, Li R, Qiao X, Tian J, Su X, Wu R, Zhang R, Zhou X, Li J, Shao S: Intermedin/ adrenomedullin 2 protects against tubular cell hypoxia-reoxygenation injury in vitro by promoting cell proliferation and upregulating cyclin D1 expression. Nephrol (Carlton) 2013; 18: 623-632
12. Ding N, Zhang Y, Loughran PA, Wang Q, Tsung A, Billiar TR: TIFA upregulation after hypoxia-reoxygenation is TLR4-And MyD88-dependent and associated with HMGB1 upregulation and release. Free Radic Biol Med 2013; 63: 361-367
13. Zhang Z, Li W, Sun D, Zhao L, Zhang R, Wang Y, Zhou X, Wang H, Cao F: Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/ reoxygenation. Inflamm Res 2011; 60: 37-45
14. Gowder SJ, McMartin KE: Development of a primary culture system of rat kidney proximal tubule cells for transport studies. J Epithel Biol Pharmacol 2010; 3: 15-19
15. Umrani DNBA, Hussain T, Lokhandwala MF: Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats. Hypertension 2002; 40: 880-885
16. Feldenberg LR, Thevananther S, del Rio M, De Leon M, Devarajan P: Partial ATP depletion induces Fas-And caspase-mediated apoptosis in MDCK cells. Am J Physiol 1999; 276:F837-F846
17. Bacallao R, Garfinkel A, Monke S, Zampighi G, Mandel LJ: ATP depletion: A novel method to study junctional properties in epithelial tissues. I. Rearrangement of the actin cytoskeleton. J Cell Sci 1994; 107: 3301-3313
18. Biju MP, Akai Y, Shrimanker N, Haase VH: Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependent. Am J Physiol Renal Physiol 2005; 289:F1217-F1226
19. Scarabelli TM, Stephanou A, Pasini E, Comini L, Raddino R, Knight RA, Latchman DS: Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Circ Res 2002; 90: 745-748
20. Liedtke C, Trautwein C: The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. Eur J Cell Biol 2012; 91: 582-589
21. Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, Van Der Poll T, Weening JJ, Florquin S: Renalassociated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005; 115: 2894-2903
22. Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S: Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 2002; 169: 6668-6672
23. Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511
24. Rao RV, Ellerby HM, Bredesen DE: Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 2004; 11: 372-380
25. Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D: Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 2000; 6: 1099-1108
26. Matsumoto M, Minami M, Takeda K, Sakao Y, Akira S: Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett 1996; 395: 143-147
27. McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ: Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 2001; 21: 1249-1259
28. Schneider P, Tschopp J: Apoptosis induced by death receptors. Pharm Acta Helv 2000; 74: 281-286
29. Yamaguchi H, Wang H-G: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 2004; 279: 45495-45502
30. Shrestha N, Bahnan W, Wiley DJ, Barber G, Fields KA, Schesser K: Eukaryotic initiation factor 2 (eIF2) signaling regulates proinflammatory cytokine expression and bacterial invasion. J Biol Chem 2012; 287: 28738-28744