Effects of everolimus on oxidative stress in kidney model of ischemia/reperfusion injury

American Journal of Nephrology

Volumn 37, Issue 4, 2013, Pages 291-301

  Kezic, Aleksandra ^a,b   Thaiss, Friedrich ^c   Becker, Jan U ^e   Tsui, Tung Y ^d   Bajcetic, Milica ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

^c Division III Medical Clinic   (Serbia)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Anti oxidative enzyme; Everolimus; Glutathione; Ischemia reperfusion injury; mTOR inhibitor

Indexed keywords

CATALASE; EVEROLIMUS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITROGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE; GLUTATHIONE REDUCTASE; OXIDOREDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REPRESSION; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; KIDNEY; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY NECROSIS; MALE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; TISSUE LEVEL; UREA NITROGEN BLOOD LEVEL; DRUG EFFECT; ENZYME ACTIVITY; NITROSATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; CATALASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; MICE; MICE, INBRED C57BL; NADP; OXIDATIVE STRESS; REPERFUSION INJURY; SIROLIMUS; SUPEROXIDE DISMUTASE;

EID: 84875664759     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000348496     Document Type: Article

References (37)

1. Perico N, Cattaneo D, Sayegh M.H., Remuzzi G: Delayed graft function in kidney transplantation. Lancet 2004; 364: 1814-1827. (Pubitemid 39488068)
2. Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011; 121: 4210-4221.
3. Shlafer M, Myers CL, Adkins S: Mitochondrial hydrogen peroxide generation and activities of glutathione peroxidase and superoxide dismutase following global ischemia. Mol Cell Cardiol 1987; 19: 1195-1206. (Pubitemid 18068093)
4. Li C, Wright MM, Jackson RM: Reactive species mediated injury of human lung epithelial cells after hypoxia reoxygenation. Exp Lung Res 2002; 28: 373-389. (Pubitemid 34620667)
5. Land W, Schneeberger H, Schleibner S., Illner WD, Abendroth D, Rutili G, Arfors K.E., Messmer K: The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 1994; 57: 211-217. (Pubitemid 24048587)
6. Liang HL, Hilton G, Mortensen J., Regner K, Johnson CP, Nilakantan V: MnTMPyP, a cellpermeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemiareperfusion. Am J Physiol Renal Physiol 2009; 296:F266-F276.
7. Kirsch M, De Groot H: NAD(P)H, a directly operating antioxidant? FASEB J 2001; 15: 1569-1574. (Pubitemid 32673387)
8. Droge W: Free radicals in the physiological control of cell function. Physiol Rev 2002; 82: 47-95. (Pubitemid 34654215)
9. Akagi R, Takahashi T, Sassa S: Fundamental role of heme oxygenase in the protection against ischemic acute renal failure. Jpn J Pharmacol 2002; 88: 127-132. (Pubitemid 34223560)
10. Attuwaybi BO, Kozar RA, Moore-Olufemi SD, Sato N., Hassoun HT, Weisbrodt NW, Moore FA: Heme oxygenase-1 induction by hemin protects against gut ischemia/reperfusion injury. J Surg Res 2004; 118: 53-57. (Pubitemid 38490516)
11. 2+ -independent permeabilization of the inner mitochondrial membrane by peroxynitrite is mediated by membrane protein thiol cross-linking and lipid peroxidation. Arch Biochem Biophys 1997; 345: 243-250. (Pubitemid 27400617)
12. Beckman JS, Beckman TW, Chen J, Marshall P.A., Freeman BA: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620-1624.
13. Gonçalves G.M., Cenedeze MA, Feitoza C.Q., de Paula CB, Marques GD, Pinheiro HS, de Paula Antunes Teixeira V, Antonia dos Reis M, Pacheco-Silva A, Camara NO: The role of immunosuppressive drugs in aggravating renal ischemia and reperfusion injury. Transplant Proc 2007; 39: 417-420. (Pubitemid 46386247)
14. McTaggart RA, Gottlieb D, Brooks J., Bacchetti P, Roberts JP, Tomlanovich S, Feng S: Sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation. Am J Transplant 2003; 3: 416-423. (Pubitemid 36560092)
15. Boratynska M, Banasik M, Patrzalek D., Szyber P, Klinger M: Sirolimus delays recovery from posttransplant renal failure in kidney graft recipients. Transplant Proc 2005; 37: 839-842. (Pubitemid 40590719)
16. Lieberthal W, Fuhro R, Andry C.C., Rennke H., Abernathy VE, Koh JS, Valeri R, Levine JS: Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 2001; 281:F693-F706.
17. Lui SL, Chan KW, Tsang R, Yung S., Lai KN, Chan TM: Effect of rapamycin on renal ischemia-reperfusion injury in mice. Transplant Int 2006; 19: 834-839. (Pubitemid 44358851)
18. Schieke SM, Phillips D, McCoy JP Jr, Aponte AM, Shen RF, Balaban RS, Finkel T: The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem 2006; 281: 27643-27652. (Pubitemid 44401789)
19. Visner GA, Lu F, Zhou H., Liu J, Kazemfar K, Agarwal A: Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin. Circulation 2003; 107: 911-916. (Pubitemid 36241052)
20. Misra HP, Fridovich I: The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247: 3170-3175.
21. Claiborne A: Assay for catalase; in Greenwald RA (ed): Handbook of Methods for Oxygen Radical Research. Boca Raton, CRC Press, 1985, pp 283-284.
22. Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-169.
23. Glatzle D, Vuilleumier JP, Weber F, Decker K: Glutathione reductase test with whole blood a convenient procedure for the assessment of the riboflavin status in humans. Experientia 1974; 30: 665-667.
24. Akerboom TP, Sies H: Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol 1981; 77: 373-382.
25. Lee SM, Koh HJ, Park D.C., Song BJ, Huh TL, Park JW: Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. Free Radic Biol Med 2002; 32: 1185-1196. (Pubitemid 34603355)
26. Zerez CR, Lee SJ, Tanaka KR: Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure. Anal Biochem 1987; 164: 367-373. (Pubitemid 17123608)
27. Lieberthal W, Fuhro R, Andry C., Patel V, Levine JS: Rapamycin delays but does not prevent recovery from acute renal failure: role of acquired tubular resistance. Transplantation 2006; 82: 17-22. (Pubitemid 44296972)
28. Esposito C, Grosjean F, Torreggiani M., Esposito V, Mangione F, Villa L., Sileno G, Rosso R, Serpieri N., Molinaro M, Fasoli G, Dal Canton A: Sirolimus prevents short-term renal changes induced by ischemia-reperfusion injury in rats. Am J Nephrol 2011; 33: 239-249.
29. Dhalla NS, Elmoselhi AB, Hata T, Makino N: Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 2000; 47: 446-456. (Pubitemid 30646067)
30. Murphy MP: How mitochondria produce reactive oxygen species. Biochem J 2009; 417: 1-13.
31. Suyani E, Derici UB, Sahin T, Ofluoglu E., Pasaoglu H, Erdem O, Barit G., Reis KA, Erten Y, Arinsoy T, Sindel S: Effects of everolimus on cytokines, oxidative stress and renal histology in ischemia-reperfusion injury of the kidney. Ren Fail 2009; 31: 698-703.
32. Gonçalves G.M., Cenedeze MA, Feitoza C.Q., Wang PM, Bertocchi AP, Damião MJ, Pinheiro H.S., Antunes Teixeira VP, dos Reis MA, Pacheco-Silva A, Câmara NO: The role of heme oxygenase 1 in rapamycin-induced renal dysfunction after ischemia and reperfusion injury. Kidney Int 2006; 70: 1742-1749. (Pubitemid 44684805)
33. Kitamuro T, Takahashi K, Ogawa K., UdonoFujimori R, Takeda K, Furuyama K., Nakayama M, Sun J, Fujita H., Hida W, Hattori T, Shirato K., Igarashi K, Shibahara S: Bach1 functions as a hypoxia inducible repressor for the heme oxygenase-1 gene in human cells. J Biol Chem 2003; 278: 9125-9133. (Pubitemid 36800393)
34. Sikorski EM, Hock T, Hill-Kapturczak N, Agarwal A: The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury. Am J Physiol Renal Physiol 2004; 286:F425-F441. (Pubitemid 38233635)
35. Yun N, Eum HA, Lee SM: Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats. Antioxid Redox Signal 2010; 13: 1503-1512.
36. Noiri E, Peresleni T, Miller F., Goligorsky MS: In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 1996; 97: 2377-2383. (Pubitemid 26165727)
37. Noiri E, Nakao A, Uchida K., Tsukahara H, Ohno M, Fujita T., Brodsky S, Goligorsky MS: Oxidative and nitrosative stress in acute renal ischemia. Am J Physiol Renal Physiol 2001; 281:F948-F957.