Prolonged exposure to arecoline arrested human KB epithelial cell growth: Regulatory mechanisms of cell cycle and apoptosis

Toxicology

Volumn 220, Issue 2-3, 2006, Pages 81-89

  Lee, Po Hsuen ^a   Chang, Mei Chi ^b   Chang, Wen Hui ^c   Wang, Tong Mei ^a   Wang, Ying Jen ^d   Hahn, Liang Jiunn ^a   Ho, Yuan Soon ^e   Lin, Chuan Yu ^b   Jeng, Jiiang Huei ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Areca nut; Arecoline; Betel quid; Carcinogenesis; Cell cycle; Epithelial cells

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ARECOLINE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; PROTEIN; PROTEIN P21; PROTEIN WEE 1; SULFORHODAMINE B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BETEL NUT; CARCINOGENESIS; CELL COUNT; CELL CYCLE ARREST; CELL DEATH; CELL GROWTH; CELL STRAIN KB; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; ENZYME INDUCTION; EPITHELIUM CELL; GINGIVA; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

APOPTOSIS; ARECOLINE; CALCIUM COMPOUNDS; CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; DNA FRAGMENTATION; HUMANS; KB CELLS; OXIDES; PIPER; PLANT EXTRACTS; RHODAMINES;

ARECA; ARECA CATECHU; PIPER BETEL;

EID: 33244454555     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.07.026     Document Type: Article

References (37)

1. waf1/cip1 in premalignant and malignant oral lesions: relationship with p53 status Oral Oncol. 34 1998 353 360
2. F. Alby, R. Mazars, J. de Rycke, E. Guillou, V. Baldin, J.M. Darbon, and B. Ducommun Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint: involvement of the CHK2 kinase FEBS Lett. 491 2001 261 265
3. M.C. Chang, M.Y. Kuo, L.J. Hahn, C.C. Hsieh, S.K. Lin, and J.H. Jeng Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts J. Periodontol. 69 1998 1092 1097
4. M.C. Chang, Y.S. Ho, P.H. Lee, C.P. Chan, J.J. Lee, L.J. Hahn, Y.J. Wang, and J.H. Jeng Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential Carcinogenesis 22 2001 1527 1535
5. Y.C. Chang, C.C. Hu, C.K. Lii, K.W. Tai, S.H. Yang, and M.Y. Chou Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro Clin. Oral Investig. 5 2001 51 56
6. M.C. Chang, B.J. Uang, H.L. Wu, J.J. Lee, L.J. Hahn, and J.H. Jeng Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol: roles of glutathione and reactive oxygen species Br. J. Pharmacol. 135 2002 619 630
7. M.C. Chang, H.L. Wu, J.J. Lee, P.H. Lee, H.H. Chang, L.J. Hahn, B.R. Lin, Y.J. Chen, and J.H. Jeng The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation J. Biol. Chem. 279 2004 50676 50683
8. C.P. Chiang, R.P. Hsieh, T.H. Chen, Y.F. Chang, B.Y. Liu, J.T. Wang, A. Sun, and M.Y. Kuo High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis J. Oral Pathol. Med. 31 2002 402 409
9. A. Eastman, and J.R. Rigas Modulation of apoptosis signaling pathways and cell cycle regulation Semin. Oncol. 26 1999 7 16 (discussion 41-12)
10. S.J. Elledge Cell cycle checkpoints: preventing an identity crisis Science 274 1996 1664 1672
11. J.W. Harper, S.J. Elledge, K. Keyomarsi, B. Dynlacht, L.H. Tsai, P. Zhang, S. Dobrowolski, C. Bai, L. Connell-Crowley, and E. Swindell Inhibition of cyclin-dependent kinases by p21 Mol. Biol. Cell 6 1995 387 400
12. W. Harvey, A. Scutt, S. Meghji, and J.P. Canniff Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids Arch. Oral Biol. 31 1986 45 49
13. IARC, 2004. Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC Monogr. Eval. Carcinog. Risks Hum. 85, 1-334.
14. J.H. Jeng, L.J. Hahn, B.R. Lin, C.C. Hsieh, C.P. Chan, and M.C. Chang Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes J. Oral Pathol. Med. 28 1999 64 71
15. J.H. Jeng, Y.S. Ho, C.P. Chan, Y.J. Wang, L.J. Hahn, D. Lei, C.C. Hsu, and M.C. Chang Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes Carcinogenesis 21 2000 1365 1370
16. J.H. Jeng, M.C. Chang, and L.J. Hahn Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives Oral Oncol. 37 2001 477 492
17. J.H. Jeng, Y.J. Wang, B.L. Chiang, P.H. Lee, C.P. Chan, Y.S. Ho, T.M. Wang, J.J. Lee, L.J. Hahn, and M.C. Chang Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline Carcinogenesis 24 2003 1301 1315
18. Q.A. Khan, K.H. Vousden, and A. Dipple Cellular response to DNA damage from a potent carcinogen involves stabilization of p53 without induction of p21(waf1/cip1) Carcinogenesis 18 1997 2313 2318
19. J.M. Li, and G. Brooks Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system: potential targets for therapy? Eur. Heart J. 20 1999 406 420
20. M.H. Lin, F.P. Chou, H.P. Huang, J.D. Hsu, M.Y. Chou, and C.J. Wang The tumor promoting effect of lime-piper betel quid in JB6 cells Food Chem. Toxicol. 41 2003 1463 1471
21. B.C. McKay, M. Ljungman, and A.J. Rainbow Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair UV sensitivity and the induction of apoptosis Oncogene 17 1998 545 555
22. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
23. A. Mukherjee, and A.K. Giri Sister chromatid exchange induced by 'pan masala' (a betel quid ingredient) in male mice in vivo Food Chem. Toxicol. 29 1991 401 403
24. S. Nagata, H. Nagase, K. Kawane, N. Mukae, and H. Fukuyama Degradation of chromosomal DNA during apoptosis Cell Death Differ. 10 2003 108 116
25. J. Nair, H. Ohshima, M. Friesen, A. Croisy, S.V. Bhide, and H. Bartsch Tobacco-specific and betel nut-specific N-nitroso compounds: occurrence in saliva and urine of betel quid chewers and formation in vitro by nitrosation of betel quid Carcinogenesis 6 1985 295 303
26. T.J. O'Brien, S. Ceryak, and S.R. Patierno Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms Mutat. Res. 533 2003 3 36
27. P.A. Reichart Oral cancer and precancer related to betel and miang chewing in Thailand: a review J. Oral Pathol. Med. 24 1995 241 243
28. J.R. Saikia, F.H. Schneeweiss, and R.N. Sharan Arecoline induced changes of poly-ADP-ribosylation of cellular proteins and its influence on chromatin organization Cancer Lett. 139 1999 59 65
29. I. Sanchez, and B.D. Dynlacht New insights into cyclins, CDKs, and cell cycle control Semin. Cell Dev. Biol. 16 2005 311 321
30. R.E. Shackelford, W.K. Kaufmann, and R.S. Paules Cell cycle control, checkpoint mechanisms, and genotoxic stress Environ. Health Perspect. 107 Suppl. 1 1999 5 24
31. R.E. Shackelford, W.K. Kaufmann, and R.S. Paules Oxidative stress and cell cycle checkpoint function Free Radic. Biol. Med. 28 2000 1387 1404
32. L.P. Shirname, M.M. Menon, J. Nair, and S.V. Bhide Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients Nutr. Cancer 5 1983 87 91
33. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd New colorimetric cytotoxicity assay for anticancer-drug screening J. Natl. Cancer Inst. 82 1990 1107 1112
34. M.L. Smith, and A.J. Fornace Jr. Mammalian DNA damage inducible genes associated with growth arrest and apoptosis Mutat. Res. 340 1996 109 124
35. K. Sundqvist, Y. Liu, J. Nair, H. Bartsch, K. Arvidson, and R.C. Grafstrom Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells Cancer Res. 49 1989 5294 5298
36. C.R. Trivedy, G. Craig, and S. Warnakulasuriya The oral health consequences of chewing areca nut Addict. Biol. 7 2002 115 125
37. R.I. Yarden, S. Pardo-Reoyo, M. Sgagias, K.H. Cowan, and L.C. Brody BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage Nat. Genet. 30 2002 285 289