Areca nut-induced buccal mucosa fibroblast contraction and its signaling: A potential role in oral submucous fibrosis-a precancer condition

Carcinogenesis

Volumn 34, Issue 5, 2013, Pages 1096-1104

  Chang, Mei Chi ^a   Lin, Li Deh ^b   Wu, Hui Lin ^c   Ho, Yuan Soon ^d   Hsien, Hsiang Chi ^e   Wang, Tong Mei ^b   Jeng, Po Yuan ^b   Cheng, Ru Hsiu ^b   Hahn, Liang Jiunn ^b   Jeng, Jiiang Huei ^b  

^a CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ARECAIDINE; ARECOLINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CALMODULIN; CARBOXYLESTERASE; CATALASE; COLLAGEN GEL; CYTOCHALASIN B; EGTAZIC ACID; INOSITOL TRISPHOSPHATE; MESSENGER RNA; MYOSIN LIGHT CHAIN; REACTIVE OXYGEN METABOLITE; RHO KINASE; SUPEROXIDE DISMUTASE; VERAPAMIL;

ARTICLE; BETEL NUT; CHEEK MUCOSA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN TISSUE; MOUTH DISEASE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WOUND HEALING;

ARECA; ARECOLINE; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; FIBROBLASTS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MOUTH MUCOSA; MOUTH NEOPLASMS; MYOSIN LIGHT CHAINS; NUTS; ORAL SUBMUCOUS FIBROSIS; PHOSPHORYLATION; PLANT EXTRACTS; PRECANCEROUS CONDITIONS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84877592734     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt012     Document Type: Article

References (61)

1. Warnakulasuriya, S. (1987) Semi-quantitative clinical description of oral submucous fibrosis. Ann. Dent., 46, 18-21.
2. Jeng, J.H. et al. (2001) Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol., 37, 477-492.
3. IARC (2004) Betel-quid and areca-nut chewing and some arecanut-derived nitrosamines. IARC Monographs on the Evaluation of Carcinogenic Risks to Human, Vol. 85. International Agency for Research on Cancer, Lyon.
4. Zhang, X. et al. (2007) A review of betel quid chewing, oral cancer and precancer in Mainland China. Oral Oncol., 43, 424-430.
5. Sharan, R.N. et al. (2010) Chapter 15 "Betel nut and susceptibility to cancer". In Roy, D. and Dorak, M.T. (eds) Environmental Factors, Genes and Development of Human Cancers. Springer Science, Springer, New York, USA, pp. 401-428.
6. Desai, P.B. (1983) Clinical cancer research in India: present status and future prospects. Indian J. Med. Res., 78, 8-28.
7. DOH New Cancer Cases Report. (2008) Bureau of Health Promotion, Department of Health, Republic of China (ROC).
8. Cox, S.C. et al. (1996) Oral submucous fibrosis. A review. Aust. Dent. J., 41, 294-299.
9. Pindborg, J.J. (1980) Oral Cancer and Precancer. Bristol: John Wright, pp. 108-111.
10. Tilakaratne, W.M. et al. (2006) Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol., 42, 561-568.
11. Murti, P.R. et al. (1995) Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing. J. Oral Pathol. Med., 24, 145-152.
12. Kaur, J. et al. (2001) Co-expression of colligin and collagen in oral submucous fibrosis: plausible role in pathogenesis. Oral Oncol., 37, 282-287.
13. Yang, S. et al. (2005) Ca2+ influx through L-type Ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration. J. Biol. Chem., 280, 27130-27137.
14. Shieh, D.H. et al. (2003) Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis. Oral Oncol., 39, 728-735.
15. Trivedy, C.R. et al. (2000) Raised tissue copper levels in oral submucous fibrosis. J. Oral Pathol. Med., 29, 241-248.
16. Tsai, C.C. et al. (1999) Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in vitro as a possible mechanism for oral submucous fibrosis. J. Oral Pathol. Med., 28, 59-63.
17. Jeng, J.H. et al. (2000) Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. Carcinogenesis, 21, 1365-1370.
18. Jeng, J.H. et al. (2003) Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis, 24, 1301-1315.
19. Grinnell, F. (2000) Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading. Trends Cell Biol., 10, 362-365.
20. Grinnell, F. (2003) Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol., 13, 264-269.
21. Chang, M.C. et al. (2004) The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation. J. Biol. Chem., 279, 50676-50683.
22. Jeng, J.H. et al. (1994) Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts. J. Dent. Res., 73, 1043-1049.
23. Jeng, J.H. et al. (1999) Arecoline cytotoxicity to human oral mucosal fibroblasts is related to thiol levels and esterase activities. Food Chem. Toxicol., 37, 751-756.
24. Chang, M.C. et al. (2001) Thrombin activates the growth, clustering, collagen lattice contraction. J. Periodontol., 72, 303-313.
25. Jeng, J.H. et al. (2006) Signaling mechanism of thrombin-induced gingival fibroblast-populated collagen gel contraction. Br. J. Pharmacol., 147, 188-198.
26. Chang, H.H. et al. (2010) The mechanisms of cytotoxicity of urethane dimethacrylate to Chinese hamster ovary cells. Biomaterials, 31, 6917-6925.
27. Chang, M.C. et al. (2010) The role of reactive oxygen species and hemeoxygenase-1 expression in the cytotoxicity, cell cycle alteration and apoptosis of dental pulp cells induced by BisGMA. Biomaterials, 31, 8164-8171.
28. Jeng, J.H. et al. (2004) Protease-activated receptor-1-induced calcium signaling in gingival fibroblasts is mediated by sarcoplasmic reticulum calcium release and extracellular calcium influx. Cell Signal., 16, 731-740.
29. Sanghani, S.P. et al. (2003) Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. Clin. Cancer Res., 9, 4983-4991.
30. Chang, M.C. et al. (2012) Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity. Acta Biomater., 8, 1380-1387.
31. Nair, U.J. et al. (1990) Effect of lime composition on the formation of reactive oxygen species from areca nut extract in vitro. Carcinogenesis, 11, 2145-2148.
32. Trivedy, C. et al. (2001) Copper stimulates human oral fibroblasts in vitro: a role in the pathogenesis of oral submucous fibrosis. J. Oral Pathol. Med., 30, 465-470.
33. Chang, M.C. et al. (2005) Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol., 41, 757-775.
34. Darby, I.A. et al. (2007) Fibroblast differentiation in wound healing and fibrosis. Int. Rev. Cytol., 257, 143-179.
35. Cox, S. et al. (2010) Salivary arecoline levels during areca nut chewing in human volunteers. J. Oral Pathol. Med., 39, 465-469.
36. Nair, J. et al. (1985) Tobacco-specific and betel nut-specific N-nitroso compounds: occurrence in saliva and urine of betel quid chewers and formation in vitro by nitrosation of betel quid. Carcinogenesis, 6, 295-303.
37. de Miranda, C.M. et al. (1996) The effect of areca nut on salivary and selected oral microorganisms. Int. Dent. J., 46, 350-356.
38. Dallon, J.C. et al. (2008) A review of fibroblast-populated collagen lattices. Wound Repair Regen., 16, 472-479.
39. Tian, B. et al. (2002) beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/ protein kinase B signaling pathway. J. Biol. Chem., 277, 24667-24675.
40. Arisawa, S. et al. (1996) Effect of the hydroxyl radical on fibroblast-mediated collagen remodelling in vitro. Clin. Exp. Pharmacol. Physiol., 23, 222-228.
41. Sugiura, H. et al. (2006) Reactive nitrogen species augment fibroblastmediated collagen gel contraction, mediator production, and chemotaxis. Am. J. Respir. Cell Mol. Biol., 34, 592-599.
42. Chang, M.C. et al. (2001) Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis, 22, 1527-1535.
43. Sambo, B. et al. (2001) Oxidative stress in sclerodermal: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum. 44, 2653-2664.
44. Dooley, A. et al. (2010) Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate. Rheumatology (Oxford), 49, 2024-2036.
45. Harvey, W. et al. (1986) Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids. Arch. Oral Biol., 31, 45-49.
46. Giri, S. et al. (2007) The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases. Biochem. Pharmacol., 73, 561-573.
47. He, Y. et al. (1995) Role of phospholipase D in the cAMP signal transduction pathway activated during fibroblast contraction of collagen matrices. J. Cell Biol., 130, 1197-1205.
48. Langholz, O. et al. (1997) Cell-matrix interactions induce tyrosine phosphorylation of MAP kinases ERK1 and ERK2 and PLCgamma-1 in twodimensional and three-dimensional cultures of human fibroblasts. Exp. Cell Res., 235, 22-27.
49. Kohyama, T. et al. (2002) PGD(2) modulates fibroblast-mediated native collagen gel contraction. Am. J. Respir. Cell Mol. Biol., 27, 375-381.
50. 2+-independent myosin II phosphorylation and contraction in chicken embryo fibroblasts. J. Physiol., 515, 87-92.
51. Balla, T. et al. (1998) Signaling events activated by angiotensin II receptors: what goes before and after the calcium signals. Endocr. Res., 24, 335-344.
52. Pellegrin, S. et al. (2007) Actin stress fibres. J. Cell Sci., 120, 3491-3499.
53. Katoh, K. et al. (2001) Rho-kinase-mediated contraction of isolated stress fibers. J. Cell Biol., 153, 569-584.
54. Nobe, H. et al. (2003) Rho kinase mediates serum-induced contraction in fibroblast fibers independent of myosin LC20 phosphorylation. Am. J. Physiol. Cell Physiol., 284, C599-C606.
55. Emmert, D.A. et al. (2003) Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts. Am. J. Physiol., 286, C8-C21.
56. Ehrlich, E.P. et al. (1989) Physiological variables affecting collagen lattice contraction by human dermal fibroblasts. Exp. Mol. Pathol., 50, 220-229.
57. Ehrlich, H.P. et al. (1991) Demonstration of a direct role for myosin light chain kinase in fibroblast-populated collagen lattice contraction. J. Cell Physiol., 146, 1-7.
58. Katoh, K. et al. (2001) Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts. Am. J. Physiol. Cell Physiol., 280, C1669-C1679.
59. Emmert, D.A. et al. (2004) Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts. Am. J. Physiol. Cell Physiol., 286, C8-C21.
60. Endlich, N. et al. (2007) Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cells. Cell Motil. Cytoskeleton, 64, 966-976.
61. Levinson, H. et al. (2004) Calmodulin-myosin light chain kinase inhibition changes fibroblast-populated collagen lattice contraction, cell migration, focal adhesion formation, and wound contraction. Wound Repair Regen., 12, 505-511.