Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene

Diabetologia

Volumn 49, Issue 8, 2006, Pages 1827-1837

  Hojlund K ^a   Wojtaszewski, J F P ^b   Birk, J ^b   Hansen, B F ^c   Vestergaard, H ^b   Beck Nielsen, H ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Glucose metabolism; Glycogen synthase; Insulin clearance; Insulin receptor mutation; Insulin signalling

Indexed keywords

GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3ALPHA; INSULIN; INSULIN RECEPTOR; PROTEIN KINASE B; SERINE; THREONINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CARRIER; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE MUTATION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HETEROZYGOTE; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; INSULIN RESISTANCE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADULT; AMINO ACID SUBSTITUTION; ARGININE; BLOOD GLUCOSE; FEMALE; GLUTAMINE; HETEROZYGOTE DETECTION; HUMANS; INSULIN; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MUTATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 33745797476     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0312-6     Document Type: Article

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