Implementation of proton transfer reaction-mass spectrometry (PTR-MS) for advanced bioprocess monitoring

Biotechnology and Bioengineering

Volumn 109, Issue 12, 2012, Pages 3059-3069

  Luchner, Markus ^a   Gutmann, Rene ^a,b   Bayer, Karl ^a   Dunkl, Jürgen ^b   Hansel, Armin ^b,d   Herbig, Jens ^b   Singer, Wolfgang ^b   Strobl, Florian ^a   Winkler, Klaus ^b   Striedner, Gerald ^a,c  

^a AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

^b Ionimed Analytik GmbH   (Austria)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Bioprocess monitoring; E. coli fermentation process; On line monitoring; Proton transfer reaction mass spectrometry (PTR MS); Volatile organic compound (VOC)

Indexed keywords

ADVANCED PROCESS CONTROL; BIOPROCESS MONITORING; BIOPROCESSES; CELL PHYSIOLOGY; CONDENSATE TRAPS; CONTINUOUS SAMPLING; DYNAMIC RANGE; ENTIRE SYSTEM; FERMENTATION PROCESS; HEADSPACE GAS; HEADSPACES; HIGH REPRODUCIBILITY; IN-PROCESS CALIBRATION; INERT SURFACES; MULTI-PORT; ONLINE MONITORING; ORDERS OF MAGNITUDE; PROCESS MATRIX; PROTON-TRANSFER REACTION MASS SPECTROMETRIES; RECOMBINANT E. COLI; RECORDED SIGNALS; SAMPLING LINES; VOLATILE COMPOUNDS;

BIOCONVERSION; BIOREACTORS; CHARGE TRANSFER; CYTOLOGY; ESCHERICHIA COLI; FERMENTATION; INTELLIGENT CONTROL; MASS SPECTROMETRY; SINTERING; VOLTAGE MEASUREMENT;

VOLATILE ORGANIC COMPOUNDS;

VOLATILE ORGANIC COMPOUND;

ARTICLE; BACTERIAL STRAIN; BIOPROCESS; ESCHERICHIA COLI; FERMENTATION MONITORING; MASS SPECTROMETRY; NONHUMAN; ONLINE SYSTEM; PROCESS MONITORING; PROTON TRANSFER REACTION MASS SPECTROMETRY; PROTON TRANSPORT;

BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; EQUIPMENT DESIGN; ESCHERICHIA COLI; FERMENTATION; MASS SPECTROMETRY; OXYGEN; REPRODUCIBILITY OF RESULTS; SIGNAL PROCESSING, COMPUTER-ASSISTED; VOLATILE ORGANIC COMPOUNDS;

EID: 84868119104     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24579     Document Type: Article

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