Retinal cell death and current strategies in retinal neuroprotection

Current Opinion in Ophthalmology

Volumn 25, Issue 3, 2014, Pages 228-233

  Chinskey, Nicholas D ^a   Besirli, Cagri G ^a   Zacks, David N ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

apoptosis; autophagy; necroptosis; neuroprotection; photoreceptor

Indexed keywords

ANTIOXIDANT; CALPAIN; FAS ANTIGEN; NEUROPROTECTIVE AGENT;

APOPTOSIS; AUTOPHAGY; CELL DEATH; EYE PROTECTION; HUMAN; NECROPTOSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RETINA CELL; RETINA NECROSIS; RETINA NEUROPROTECTION; RETINITIS; REVIEW;

APOPTOSIS; CELL SURVIVAL; HUMANS; NEUROPROTECTIVE AGENTS; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL DISEASES; VISION DISORDERS;

EID: 84898458550     PISSN: 10408738     EISSN: 15317021     Source Type: Journal    
DOI: 10.1097/ICU.0000000000000043     Document Type: Review

References (42)

1. Huckfeldt RM, Vavvas DG. Neuroprotection for retinal detachment. Int Ophthalmol Clin 2013; 53:105-117.
2. Valverde AM, Miranda S, Garcý́a-Ramý́rez M, et al. Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy. Mol Vis 2013; 19:47-53.
3. Zacks DN, Zheng QD, Han Y, et al. FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 2004; 45:4563-4569. (Pubitemid 39564684)
4. Zacks DN, Boehlke C, Richards AL, Zheng QD. Role of the Fas-signaling pathway in photoreceptor neuroprotection. Arch Ophthalmol 2007; 125: 1389-1395. (Pubitemid 47606606)
5. Besirli CG, Chinskey ND, Zheng QD, Zacks DN. Inhibition of retinal detachment-induced apoptosis in photoreceptors by a small peptide inhibitor of the fas receptor. Invest Ophthalmol Vis Sci 2010; 51: 2177-2184.
6. Besirli CG, Zheng QD, Reed DM, Zacks DN. ERK-mediated activation of Fas apoptotic inhibitory molecule 2 (Faim2) prevents apoptosis of 661W cells in a model of detachment-induced photoreceptor cell death. PLoS One 2012; 7:e46664.
7. Hernández C, Garcý́a-Ramý́rez M, Corraliza L, et al. Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes. Diabetes 2013; 62:2569-2578.
8. Liu Y, Leo LF, McGregor C, et al. Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice. Mol Med 2012; 18: 1387-1401.
9. Wang Y, Subramanian P, Shen D, et al. Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in the murine model of focal retinal degeneration. ASN Neuro 2013; 5:e00126.
10. Akiyama G, Sakai T, Kuno N, et al. Photoreceptor rescue of pigment epithelium-derived factor-impregnated nanoparticles in Royal College of Surgeons rats. Mol Vis 2012; 18:3079-3086.
11. Villacampa P, Ribera A, Motas S, et al. Insulin-like growth factor 1 (IGF-1)-induced chronic gliosis and retinal stress lead to neurodegeneration in a mouse model of retinopathy. J Biol Chem 2013; 288:17631-17642.
12. Huang W, Li G, Qiu J, et al. Protective effects of resveratrol in experimental retinal detachment. PLoS One 2013; 8:e75735.
13. Park MH, Kim SY, Moon C, et al. Differential cell death and Bcl-2 expression in the mouse retina after glutathione decrease by systemic D,L-buthionine sulphoximine administration. Mol Cells 2013; 35:235-242.
14. Lulli M, Witort E, Papucci L, et al. Coenzyme Q10 installed as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage. Invest Ophthalmol Vis Sci 2012; 53:8295-8302.
15. Schallner N, Fuchs M, Schwer CI, et al. Postconditioning with inhaled carbon monoxide counteracts apoptosis and neuroinflammation in the ischemic rat retina. PLoS One 2012; 7:e46479.
16. Notomi S, Hisatomi T, Murakami Y, et al. Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage. PLoS One 2013; 8:e53338.
17. Zhu H, Qian J, Wang W, et al. RNA interference of GADD153 protects photoreceptors from endoplasmic reticulum stress-mediated apoptosis after retinal detachment. PLoS One 2013; 8:e59339.
18. Hamann S, Mé trailler S, Schorderet DF, Cottet S. Analysis of the cytoprotective role of alpha-crystallins in cell survival and implication of the alphacrystallin C-terminal extension domain in preventing Bax-induced apoptosis. PLoS One 2013; 8:e55372.
19. Zencak D, Schouwey K, Chen D, et al. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci USA 2013; 110:E593-E601.
20. Sugitani S, Tsuruma K, Ohno Y, et al. The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. Exp Eye Res 2013; 116:254-264.
21. Barone I, Novelli E, Piano I, et al. Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa. PLoS One 2012; 7:e50726.
22. Schultheiss M, Januschowski K, Ruschenburg H, et al. Dulbecco's modified eagle medium is neuroprotective when compared to standard vitrectomy irrigation solution. Graefes Arch Clin Exp Ophthalmol 2013; 251:1613-1619.
23. Doonan F, Donovan M, Cotter TG. Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 2003; 23: 5723-5731. (Pubitemid 36807851)
24. Zeiss CJ, Neal J, Johnson EA. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 2004; 45:964-970. (Pubitemid 38868399)
25. Trichonas G, Murakami Y, Thanos A, et al. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci USA 2010; 107:21695-21700.
26. Sato K, Li S, Gordon WC, et al. Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein. J Neurosci 2013; 33: 17458-17468.
27. Murakami Y, Matsumoto H, Roh M, et al. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ 2014; 21:270-277.
28. Murakami Y, Matsumoto H, Roh M, et al. Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci USA 2012; 109:14598-14603.
29. Murakami Y, Miller JW, Vavvas DG. RIP kinase-mediated necrosis as an alternative mechanism of photoreceptor death. Oncotarget 2011; 2:497-509.
30. Murakami Y, Notomi S, Hisatomi T, et al. Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res 2013; 37:114-140.
31. Besirli CG, Chinskey ND, Zheng QD, Zacks DN. Autophagy activation in the injured photoreceptors inhibits fas-mediated apoptosis. Invest Ophthalmol Vis Sci 2011; 52:4193-4199.
32. Balmer D, Emery M, Andreux P, et al. Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells. PLoS One 2013; 8:e74162.
33. Chen Y, Sawada O, Kohno H, et al. Autophagy protects the retina from lightinduced degeneration. J Biol Chem 2013; 288:7506-7518.
34. Rodrý́guez-Muela N, Koga H, Garcý́a-Ledo L, et al. Balance between autophagic pathways preserves retinal homeostasis. Aging Cell 2013; 12:478-488.
35. Yousefi S, Perozzo R, Schmid I, et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 2006; 8:1124-1132. (Pubitemid 44473608)
36. Xia H, Zhang L, Chen G, et al. Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy 2010; 6:61-66.
37. Azuma M, Hammond KB, Nakajima E, Shearer T. Calpain protease causes hypoxia-induced proteolysis in cultured human retina. Curr Eye Res 2013. [Epub ahead of print]
38. Villalpando-Rodriguez GE, Torriglia A. Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2. Biochim Biophys Acta 2013; 1833:2244-2253.
39. Ozaki T, Ishiguro S, Hirano S, et al. Inhibitory peptide of mitochondrial mcalpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats. PLoS One 2013; 8:e71650.
40. Das A, Guyton MK, Smith A, et al. Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats. J Neurochem 2013; 124: 133-146.
41. Mo MS, Li HB, Wang BY, et al. PI3K/AKT and NF-kB activation following intravitreal administration of 17beta-estradiol: neuroprotection of the rat retina from light-induced apoptosis. Neuroscience 2013; 228: 1-12.
42. Cubilla MA, Bermúdez V, Marquioni-Ramella MD, et al. Mifepristone, a blocker of glucocorticoid receptors, promotes photoreceptor death. Invest Ophthalmol Vis Sci 2013; 54:313-322.