Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio)

Aquatic Toxicology

Volumn 152, Issue , 2014, Pages 57-65

  Corcoran, Jenna ^a   Lange, Anke ^a   Cumming, Rob I ^b   Owen, Stewart F ^b   Ball, Jonathan S ^b   Tyler, Charles R ^a   Winter, Matthew J ^b  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Clotrimazole; Fish; Pregnane X receptor (PXR)

Indexed keywords

CLOTRIMAZOLE; CYTOCHROME P450 3A; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR;

BIOACCUMULATION; BIOAVAILABILITY; BIOTRANSFORMATION; CYPRINID; DETOXIFICATION; FUNGICIDE; GENE EXPRESSION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CARP; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYP2K GENE; CYTOCHROME P450 3A GENE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG LIVER LEVEL; DRUG TRANSFORMATION; GENE; GENE EXPRESSION; MDR1 GENE; MRP2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

CLOTRIMAZOLE; FISH; PREGNANE X RECEPTOR (PXR);

ANIMALS; ANTIFUNGAL AGENTS; BIOTRANSFORMATION; CARPS; CLOTRIMAZOLE; GENE EXPRESSION REGULATION; LIVER; WATER POLLUTANTS, CHEMICAL;

EID: 84898436978     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2014.03.016     Document Type: Article

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