"REM-related" obstructive sleep apnea: An epiphenomenon or a clinically important entity?

Sleep

Volumn 35, Issue 1, 2012, Pages 5-7

  Mokhlesi, Babak ^a   Punjabi, Naresh M ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYHEMOGLOBIN;

CARDIOVASCULAR RISK; CLINICAL PRACTICE; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; HEALTH CARE PERSONNEL; HUMAN; HYPERTENSION; HYPOXEMIA; MUSCLE CONTRACTION; NONREM SLEEP; NOTE; OXIDATIVE STRESS; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; QUALITY OF LIFE; REM SLEEP; SLEEP APNEA SYNDROME; SYMPATHETIC TONE;

HUMANS; SLEEP APNEA, OBSTRUCTIVE; SLEEP STAGES; SLEEP, REM;

EID: 84857010241     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.1570     Document Type: Note

References (22)

1. Fenik VB, Davies RO, Kubin L. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am J Respir Crit Care Med 2005;172:1322-30. (Pubitemid 43076572)
2. Haba-Rubio J, Janssens JP, Rochat T, Sforza E. Rapid eye movementrelated disordered breathing: clinical and polysomnographic features. Chest 2005;128:3350-7. (Pubitemid 41698662)
3. Resta O, Carpanano GE, Lacedonia D et al. Gender difference in sleep profile of severely obese patients with obstructive sleep apnea (OSA). Respir Med 2005;99:91-6. (Pubitemid 40017390)
4. Koo BB, Dostal J, Ioachimescu O, Budur K. The effects of gender and age on REM-related sleep-disordered breathing. Sleep Breath 2008;12:259-64.
5. Koo BB, Patel SR, Strohl K, Hoffstein V. Rapid eye movement-related sleep-disordered breathing: influence of age and gender. Chest 2008;134:1156-61.
6. Conwell W, Patel B, Doeing D, Pamidi S, Knutson KL, Ghods F, Mokhlesi B. Prevalence, clinical features and CPAP adherence in REM-related sleep-disordered breathing: A cross-sectional analysis of a large clinical population. Sleep Breath 2011. [In Press]
7. Goh DY, Galster P, Marcus CL. Sleep architecture and respiratory disturbances in children with obstructive sleep apnea. Am J Respir Crit Care Med 2000;162:682-6. (Pubitemid 30647219)
8. O'Connor C, Thornley KS, Hanly PJ. Gender differences in the polysomnographic features of obstructive sleep apnea. Am J Respir Crit Care Med 2000;161:1465-72. (Pubitemid 30329013)
9. Chami HA, Baldwin CM, Silverman A, et al. Sleepiness, quality of life, and sleep maintenance in REM versus non-REM sleep-disordered breathing. Am J Respir Crit Care Med 2010;181:997-1002.
10. Chervin RD, Aldrich MS. The relation between multiple sleep latency test findings and the frequency of apneic events in REM and non-REM sleep. Chest 1998;113:980-4. (Pubitemid 28216442)
11. Punjabi NM, Bandeen-Roche K, Marx JJ, Neubauer DN, Smith PL, Schwartz AR. The association between daytime sleepiness and sleepdisordered breathing in NREM and REM sleep. Sleep 2002;25:307-14. (Pubitemid 34496412)
12. Pamidi S, Knutson KL, Ghods F, Mokhlesi B. Depressive symptoms and obesity as predictors of sleepiness and quality of life in patients with REM-related obstructive sleep apnea: Cross-sectional analysis of a large clinical population. Sleep Med 2011;12:827-831.
13. Kass JE, Akers SM, Bartter TC, Pratter MR. Rapid-eye-movement-specific sleep-disordered breathing: a possible cause of excessive daytime sleepiness. Am J Respir Crit Care Med 1996;154:167-9. (Pubitemid 26255784)
14. Somers VK, Dyken ME, Mark AL, Abboud FM. Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med 1993;328:303-7. (Pubitemid 23035328)
15. Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995;96:1897-904.
16. Findley LJ, Wilhoit SC, Suratt PM. Apnea duration and hypoxemia during REM sleep in patients with obstructive sleep apnea. Chest 1985;87:432-6. (Pubitemid 15083477)
17. Redline S, Storfer-Isser A, Rosen CL, et al. Association between metabolic syndrome and sleep-disordered breathing in adolescents. Am J Respir Crit Care Med 2007;176:401-8. (Pubitemid 47267475)
18. Gozal D, Kheirandish-Gozal L, Serpero LD, Sans CO, Dayyat E. Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy. Circulation 2007;116:2307-14. (Pubitemid 350100337)
19. Kheirandish-Gozal L, Bhattacharjee R, Kim J, Clair HB, Gozal D. Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea. Am J Respir Crit Care Med 2010;182:92-7.
20. Bhattacharjee R, Kheirandish-Gozal L, Pillar G, Gozal D. Cardiovascular complications of obstructive sleep apnea syndrome: evidence from children. Prog Cardiovasc Dis 2009;51:416-33.
21. Gozal D, Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am J Respir Crit Care Med 2008;177:369-75. (Pubitemid 351317579)
22. Gozal D, Serpero LD, Sans CO, Kheirandish-Gozal L. Systemic inflammation in non-obese children with obstructive sleep apnea. Sleep Med 2008;9:254-9. (Pubitemid 351387097)