Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response

Diabetologia

Volumn 52, Issue 8, 2009, Pages 1537-1542

  Langenberg, C ^a   Pascoe, L ^b   Mari, A ^c   Tura, A ^c   Laakso, M ^d   Frayling, T M ^e   Barroso, I ^f   Loos, R J F ^a   Wareham, N J ^a   Walker, M ^b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c CNR   (Italy)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

^e PENINSULA MEDICAL SCHOOL   (United Kingdom)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Genome wide association; Glucose sensitivity; Insulin resistance; Insulin sensitivity; Melatonin receptor 1B; MTNR1B

Indexed keywords

GLUCOSE; INSULIN; MELATONIN 1 RECEPTOR; MELATONIN 1B RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGE; ALLELE; ARTICLE; BODY SIZE; CARDIOVASCULAR DISEASE; CELL FUNCTION; CLINICAL STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; EUGLYCEMIC HYPERINSULINEMIC CLAMP; FEMALE; GENE; GENETIC MODEL; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HAPLOTYPE MAP; HUMAN; HUMAN EXPERIMENT; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; MALE; MTNR1B GENE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SEX; TECHNIQUE; UNITED STATES; WESTERN EUROPE;

ADULT; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; MODELS, GENETIC; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2;

EID: 67650694101     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1392-x     Document Type: Article

References (21)

1. MN Weedon VJ Clark Y Qian 2006 A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses Am J Hum Genet 79 991 1001 (Pubitemid 44853472)
2. N Bouatia-Naji G Rocheleau LL Van 2008 A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels Science 320 1085 1088 (Pubitemid 351929551)
3. WM Chen MR Erdos AU Jackson 2008 Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels J Clin Invest 118 2620 2628 (Pubitemid 351949789)
4. R Saxena BF Voight V Lyssenko 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 (Pubitemid 46871653)
5. M Vaxillaire C Cavalcanti-Proenca A Dechaume 2008 The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population Diabetes 57 2253 2257
6. M Orho-Melander O Melander C Guiducci 2008 Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations Diabetes 57 3112 3121
7. I Prokopenko C Langenberg JC Florez 2009 Variants in MTNR1B influence fasting glucose levels Nature genetics 41 77 81
8. V Lyssenko CL Nagorny MR Erdos 2009 Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion Nature genetics 41 82 88
9. SA Hills B Balkau SW Coppack 2004 The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives Diabetologia 47 566 570 (Pubitemid 38491256)
10. NJ Wareham DI Phillips CD Byrne CN Hales 1995 The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion Diabet Med 12 931
11. RL Hanson RE Pratley C Bogardus 2000 Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies Am J Epidemiol 151 190 198 (Pubitemid 30463650)
12. L Pascoe A Tura SK Patel 2007 Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function Diabetes 56 3101 3104 (Pubitemid 350223648)
13. H Staiger F Machicao SA Schafer 2008 Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function PLoS ONE 3 e3962
14. RD Ramracheya DS Muller PE Squires 2008 Function and expression of melatonin receptors on human pancreatic islets J Pineal Res 44 273 279
15. N Bouatia-Naji A Bonnefond C Cavalcanti-Proenca 2009 A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk Nature genetics 41 89 94
16. G Boden J Ruiz JL Urbain X Chen 1996 Evidence for a circadian rhythm of insulin secretion Am J Physiol 271 E246 E252
17. I Stumpf E Muhlbauer E Peschke 2008 Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells J Pineal Res 45 318 327
18. FW Turek C Joshu A Kohsaka 2005 Obesity and metabolic syndrome in circadian clock mutant mice Science 308 1043 1045 (Pubitemid 40664419)
19. K Spiegel R Leproult E Van Cauter 1999 Impact of sleep debt on metabolic and endocrine function Lancet 354 1435 1439 (Pubitemid 29494756)
20. E Peschke I Stumpf I Bazwinsky L Litvak H Dralle E Muhlbauer 2007 Melatonin and type 2 diabetes-a possible link? J Pineal Res 42 350 358 (Pubitemid 46581659)
21. L Pascoe TM Frayling MN Weedon 2008 Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles Diabetologia 51 1989 1992