Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea

European Respiratory Journal

Volumn 40, Issue 4, 2012, Pages 913-918

  Sivam, Sheila ^a,b   Phillips, Craig L ^a,c,d   Trenell, Michael I ^e   Yee, Brendon J ^a,b,c   Liu, Peter Y ^a,b,c,f   Wong, Keith K ^a,b,c   Grunstein, Ronald R ^a,b,c  

^a WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d ROYAL NORTH SHORE HOSPITAL   (Australia)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Fasting glucose; Hepatic fat; Liver function test; Subcutaneous fat; Visceral fat

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; FAT; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE;

ABDOMINAL OBESITY; ADULT; ARTICLE; BODY FAT DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOWN REGULATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPOXEMIA; INTRAABDOMINAL FAT; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SLEEP DISORDERED BREATHING; SUBCUTANEOUS FAT; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME;

ABDOMINAL FAT; ADULT; BODY FAT DISTRIBUTION; CONTINUOUS POSITIVE AIRWAY PRESSURE; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; LIVER FUNCTION TESTS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; OBESITY; SLEEP APNEA, OBSTRUCTIVE; SUBCUTANEOUS FAT, ABDOMINAL;

EID: 84867119393     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00177011     Document Type: Article

References (32)

1. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328: 1230-1235. (Pubitemid 23115702)
2. Bonsignore MR, Esquinas C, Barceló A, et al. Metabolic syndrome, insulin resistance and sleepiness in real-life obstructive sleep apnoea. Eur Respir J 2012; 39: 1136-1143.
3. Lam JCM, Lam B, Yao TJ, et al. A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea. Eur Respir J 2010; 35: 138-145.
4. Harsch IA, Schahin SP, Radespiel-TrogerM, et al. Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. AmJ Respir Crit Care Med 2004; 169: 156-162. (Pubitemid 38114528)
5. Despres JP, Lemieux I, Bergeron J, et al. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 2008; 28: 1039-1049.
6. Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 2000; 85: 1151-1158. (Pubitemid 32269364)
7. Trenell MI, Ward JA, Yee BJ, et al. Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome. Diabetes Obes Metab 2007; 9: 679-687. (Pubitemid 47261849)
8. Chin K, Shimizu K, Nakamura T, et al. Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 1999; 100: 706-712. (Pubitemid 29383639)
9. Munzer T, Hegglin A, Stannek T, et al. Effects of long-term continuous positive airway pressure on body composition and IGF1. Eur J Endocrinol 2010; 162: 695-704.
10. Vgontzas AN, Zoumakis E, Bixler EO, et al. Selective effects of CPAP on sleep apnoea-associated manifestations. Eur J Clin Invest 2008; 38: 585-595. (Pubitemid 352019140)
11. Phillips CL, Yee BJ, Trenell MI, et al. Changes in regional adiposity and cardio-metabolic function following a weight loss program with sibutramine in obese men with obstructive sleep apnea. J Clin Sleep Med 2009; 5: 416-421.
12. Kohler M, Pepperell JC, Davies RJ, et al. Continuous positive airway pressure and liver enzymes in obstructive sleep apnoea: data froma randomized controlled trial. Respiration 2009; 78: 141-146.
13. Day CP. Non-alcoholic fatty liver disease: a massive problem. Clin Med 2011; 11: 176-178.
14. Norman D, Bardwell WA, Arosemena F, et al. Serum amino-transferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea. Sleep 2008; 31: 121-126.
15. Chin K, Nakamura T, Takahashi K, et al. Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients. Am J Med 2003; 114: 370-376. (Pubitemid 36513685)
16. Shpirer I, Copel L, Broide E, et al. Continuous positive airway pressure improves sleep apnea associated fatty liver. Lung 2010; 188: 301-307.
17. Phillips CL, Yee BJ, Marshall NS, et al. Continuous positive airway pressure reduces post prandial lipidemia in obstructive sleep apnea: a randomised, placebo controlled crossover trial. Am J Respir Crit Care Med 2011; 184: 355-361.
18. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22: 667-689.
19. Positano V, Gastaldelli A, Sironi AM, et al. An accurate and robust method for unsupervised assessment of abdominal fat by MRI. J Magn Reson Imaging 2004; 20: 684-689. (Pubitemid 39313745)
20. Demerath EW, Ritter KJ, Couch WA, et al. Validity of a new automated software program for visceral adipose tissue estimation. Int J Obesity 2007; 31: 285-291. (Pubitemid 46183135)
21. Naressi A, Couturier C, Castang I, et al. Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/ medical magnetic resonance spectroscopy signals. Comput Biol Med 2001; 31: 269-286. (Pubitemid 32378728)
22. Longo R, Pollesello P, Ricci C, et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imaging 1995; 5: 281-285.
23. Kullberg J, Brandberg J, Angelhed JE, et al. Whole-body adipose tissue analysis: comparison of MRI, CT and dual energy X-ray absorptiometry. Br J Radiol 2009; 82: 123-130.
24. Kuk JL, Katzmarzyk PT, Nichaman MZ, et al. Visceral fat is an independent predictor of all-cause mortality in men. Obesity (Silver Spring) 2006; 14: 336-341. (Pubitemid 46214766)
25. Nordestgaard BG, Benn M, Schnohr P, et al. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007; 298: 299-308. (Pubitemid 47080484)
26. Jang Y, Kim OY, Ryu HJ, et al. Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men. J Lipid Res 2003; 44: 2356-2364. (Pubitemid 38082494)
27. Blackburn P, Lamarche B, Couillard C, et al. Contribution of visceral adiposity to the exaggerated postprandial lipemia of men with impaired glucose tolerance. Diabetes Care 2003; 26: 3303-3309. (Pubitemid 37466891)
28. Matikainen N, Manttari S, Westerbacka J, et al. Postprandial lipemia associates with liver fat content. J Clin Endocrinol Metab 2007; 92: 3052-3059. (Pubitemid 47236370)
29. West SD, Nicoll DJ, Wallace TM, et al. Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. Thorax 2007; 62: 969-974. (Pubitemid 350084496)
30. Coughlin SR, Mawdsley L, Mugarza JA, et al. Cardiovascular and metabolic effects of CPAP in obese males with OSA. Eur Respir J 2007; 29: 720-727. (Pubitemid 46554622)
31. Smurra M, Philip P, Taillard J, et al. CPAP treatment does not affect glucose-insulin metabolism in sleep apneic patients. Sleep Med 2001; 2: 207-213. (Pubitemid 34846769)
32. Simpson L, Mukherjee S, Cooper MN, et al. Sex differences in the association of regional fat distributionwith the severity of obstructive sleep apnea. Sleep 2010; 33: 467-474.