Combination of UHPLC/Q-TOF-MS, NMR spectroscopy, and ECD calculation for screening and identification of reactive metabolites of gentiopicroside in humans

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 6, 2014, Pages 1781-1793

  Han, Han ^a   Xiong, Ai Zhen ^a   He, Chun Yong ^a   Liu, Qing ^a   Yang, Li ^a   Wang, Zheng Tao ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

ECD calculation; Gentiopicroside; Identification; Metabolic reaction; UHPLC Q TOF MS

Indexed keywords

BIOMOLECULES; CHEMICAL ACTIVATION; CIRCULAR DICHROISM SPECTROSCOPY; DICHROISM; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; IDENTIFICATION (CONTROL SYSTEMS); LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR QUADRUPOLE RESONANCE;

ELECTRONIC CIRCULAR DICHROISM; GENTIOPICROSIDE; METABOLIC REACTIONS; METABOLIC TRANSFORMATIONS; NUCLEAR MAGNETIC RESONANCE(NMR); QUADRUPOLE TIME-OF-FLIGHT TANDEM MASS SPECTROMETRIES; UHPLC/Q-TOF-MS; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

METABOLITES;

GENTIOPICRIN; IRIDOID;

ADULT; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; ELECTROSPRAY MASS SPECTROMETRY; GENTIAN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; URINE; YOUNG ADULT;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; GENTIANA; HUMANS; IRIDOID GLUCOSIDES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; YOUNG ADULT;

EID: 84898039525     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7572-z     Document Type: Article

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