HPLC/ICP-MS in combination with "reverse" online isotope dilution in drug metabolism studies

Analytical Chemistry

Volumn 84, Issue 5, 2012, Pages 2395-2401

  Meermann, Björn ^a   Hulstaert, Anne ^a   Laenen, Aline ^b   Looveren, Cis Van ^b   Vliegen, Maarten ^b   Cuyckens, Filip ^b   Vanhaecke, Frank ^a  

^a GHENT UNIVERSITY   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE APPROACH; CANDIDATE DRUGS; DRUG ADMINISTRATION; DRUG COMPOUNDS; DRUG METABOLISMS; DRUG METABOLITES; ENDOGENOUS COMPOUND; IN-VIVO; ISOTOPE DILUTIONS; LIMIT OF DETECTION; RADIO DETECTION; RADIOLABEL; RELATIVE STANDARD DEVIATIONS; TARGET ELEMENT;

BIOMOLECULES; BROMINE; BROMINE COMPOUNDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; ISOTOPES; METABOLITES; PHYSIOLOGY; TISSUE;

METABOLISM;

BROMINE; CARBON; DRUG; ISOTOPE; TRITIUM; TUBERCULOSTATIC AGENT;

ANIMAL; ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; FECES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; METABOLISM; RAT;

ANIMALS; ANTITUBERCULAR AGENTS; BROMINE; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; HUMANS; ISOTOPE LABELING; ISOTOPES; PHARMACEUTICAL PREPARATIONS; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRITIUM;

EID: 84857884315     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac203165p     Document Type: Article

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