Antiproliferative activity of root extract from gentian plant (Gentiana triflora) on cultured and implanted tumor cells

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 4, 2006, Pages 1046-1048

  Matsukawa, Kazushige ^a   Ogata, Mika ^a   Hikage, Takashi ^a,b   Minami, Hiroyuki ^a   Shimotai, Yoshitaka ^a   Saitoh, Yasushi ^a   Yamashita, Tetsuro ^a   Ouchi, Atsushi ^c   Tsutsumi, Reiko ^c   Fujioka, Tomoaki ^c   Tsutsumi, Ken Ichi ^a  

^a IWATE UNIVERSITY   (Japan)

^b Ashiro cho Floricultural Development Center   (Japan)

^c IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Antiproliferative activity; Antitumor activity; Cell death; Chinese medicine; Gentiana triflora

Indexed keywords

BIODEGRADATION; CHROMOSOMES; DNA; GROWTH KINETICS; PHARMACODYNAMICS; PLANT CELL CULTURE;

ANTIPROLIFERATIVE ACTIVITY; ANTITUMOR ACTIVITY; CELL DEATH; CHINESE MEDICINE; GENTIANA TRIFLORA;

PLANTS (BOTANY);

PLANT EXTRACT;

ANIMAL; ARTICLE; CELL PROLIFERATION; CELL SHAPE; CELL TRANSPLANTATION; CHEMISTRY; DRUG EFFECT; GENTIAN; MALE; NEOPLASM; PATHOLOGY; PLANT ROOT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CELL TRANSPLANTATION; GENTIANA; MALE; NEOPLASMS; PLANT EXTRACTS; PLANT ROOTS;

GENTIANA; GENTIANA TRIFLORA;

EID: 33646159737     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.70.1046     Document Type: Article

References (12)

1. Zhang, J. Q., and Zhou, Y. P., Inhibition of aldose reductase from rat lens by some Chinese herbs and their components. Zhongguo Zhong Yao Zha Zhi (in Chinese), 14, 557-559 (1989).
2. Huh, H., Kim, H. K., and Lee, H. K., PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose from Gentiana scabra. Arch. Pharm. Res., 21, 436-439 (1998).
3. Calliste, C.-A., Trouillas, P., Allais, D.-P., Simon, A., and Duroux, J.-L., Free radical scavenging activities measured by electron spin resonance spectroscopy and B16 antiproliferative behaviors of seven plants. J. Agric. Food Chem., 49, 3321-3327 (2001).
4. Kondo, Y., Takano, F., and Hojo, H., Suppression of chemically and immunologically induced hepatic injuries by gentiopicroside in mice. Planta Med., 60, 414-416 (1994).
5. Liu, Z. W., Chen, C. X., Jin, R. M., Shi, G. Q., Song, C. Q., and Hu, Z. B., Studies on liver-protecting and bile secretion-promoting effects of gentiopicroside. Zhongcaoyao (in Chinese), 33, 47-50 (2002).
6. Rojas, A., Bah, M., Rojas, J. I., and Gutierrez, D. M., Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea. Planta Med., 66, 765-767 (2000).
7. Salup, R. R., Back, T. C., and Wiltrout, R. H., Successful treatment of advanced murine renal cell cancer by bicompartmental adoptive chemoimmunotherapy. J. Immunol., 138, 641-647 (1987).
8. Sonouchi, K., Hamilton, T. A., Tannenbaum, C. S., Tubbs, R. R., Bukowski, R., and Finke, J. H., Chemokine gene expression in the murine renal cell carcinoma, RENCA, following treatment in vivo with interferon-alpha and interleukin-2. Am. J. Pathol., 144, 747-755 (1994).
9. Silverberg, E., and Lubera, J., Cancer statistics. CA: a Cancer Journal for Clinicians, 37, 2-19 (1987).
10. Fujioka, T., Hasegawa, M., Ogiu, K., Matsushita, Y., Sato, M., and Kubo, T., Antitumor effects of angio-genesis inhibitor o-(chloroacetyl-carbamoyl) fumagillol (TNP-470) against murine renal cell carcinoma. J. Urol., 155, 1775-1778 (1996).
11. Ellis, R. E., Yuan, J., and Horvitz, H. R., Mechanism and functions of cell death. Annu. Rev. Cell Biol., 1, 253-259 (1991).
12. Jacobson, M. D., Weil, M., and Ra., M. C., Programmed cell death in animal development. Cell, 88, 347-354 (1997).