CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells

GLIA

Volumn 62, Issue 6, 2014, Pages 982-998

  Dentesano, Guido ^a   Serratosa, Joan ^a   Tusell, Josep M ^a   Ramón, Pol ^a   Valente, Tony ^a   Saura, Josep ^b   Solà, Carme ^a  

^a INST D INVESTIGACIONS B   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Anti inflammatory; Astroglia; in vitro; Microglia; Neuroinflammation; Neuroprotection

Indexed keywords

CD200 ANTIGEN; CD200 RECEPTOR; CD200R1 PROTEIN; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN J2; UNCLASSIFIED DRUG; 15-DEOXYPROSTAGLANDIN J2; ANTIGENS, CD200; CD200R1 PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; OREXIN RECEPTOR; PROSTAGLANDIN D2;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; COCULTURE; CONTROLLED STUDY; GLIA CELL; GLIAL CELL CULTURE; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MICROGLIA; MICROGLIAL CELL CULTURE; MOUSE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; UPREGULATION; WESTERN BLOTTING; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; BRAIN CORTEX; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GLIA; METABOLISM; NEWBORN; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; NEUROGLIA; OREXIN RECEPTORS; PPAR GAMMA; PROSTAGLANDIN D2;

EID: 84898023667     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22656     Document Type: Article

References (60)

1. 2 in the regulation of microglial functions. Eur J Neurosci 12:2215-2223.
2. Block ML, Zecca L, Hong JH. 2007. Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nature Rev 8:57-69.
3. Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD. 2002. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 161:1669-1677.
4. Carta AR, Frau L, Pisanu A, Wardas J, Spiga S, Carboni E. 2011. Rosiglitazone decreases peroxisome-proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: New evidences on neuroprotection in a progressive Parkinson's disease model. Neuroscience 194:250-261.
5. s mice from inflammation-mediated neurodegeneration. Am J Pathol 170:1695-1712.
6. Colton CA. 2009. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4:399-418.
7. Copland DA, Calder CJ, Raveney BJ, Nicholson LB, Phillips J, Cherwinski H, Jenmalm M, Sedgwick JD, Dick AD. 2007. Monoclonal antibody-mediated CD200 receptor signalling supresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. Am J Pathol 171:396-398.
8. Costello DA, Lyons A, Denieffe S, Browne TC, Cox, FF, Lynch MA. 2011. Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice. J Biol Chem 286:34722-34732.
9. Cox FF, Carney D, Miller AM, Lynch MA. 2012. CD200 fusion protein decreases microglial activation in the hippocampus of aged rats. Brain Behav Immun 26:789-796.
10. Dentesano G, Straccia M, Ejarque-Ortiz A, Tusell JM, Serratosa J, Saura J, Solà C. 2012. Inhibition of CD200R1 expression by C/EBPbeta in reactive microglial cells. J Neuroinflammation 9:165.
11. Diab A, Hussain RZ, Lovett-Racke AE, Chavis JA, Derw PD, Racke MK. 2004. Ligands for the peroxisome proliferator-activated receptor-γ and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis. J Neuroimmunol 148:116-126.
12. Drew PD, Xu J, Storer PD, Chasis JA, Racke MK. 2006. Peroxisome proliferator-activated receptor agonist regulation of glial activation: Relevance to CNS inflammatory disorders. Neurochem Int 49:183-189.
13. Ejarque-Ortiz A, Medina MG, Tusell JM, Pérez-González AP, Serratosa J, Saura J. 2007. Upregulation of CCAAT/enhancer binding protein β in activated astrocytes and microglia. Glia 55:178-188.
14. Fuenzalida K, Quintanilla R, Ramos P, Piderit D, Fuentealba RA, Martinez G, Inestrosa NC, Bronfman M. 2007. Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem 282:37006-37015.
15. Giri S, Rattan R, Singh AK, Singh I. 2004. The 15-deoxy-delta12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. J Immunol 173:5196-208.
16. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. 2010. Mechanisms underlying inflammation in neurodegeneration. Cell 140:918-934.
17. Gresa-Arribas N, Serratosa J, Saura J, and Solà C. 2010. Inhibition of CCAAT/enhancer binding protein δ expression by chrysin in microglial cells results in anti-inflammatory and neuroprotective effects. J Neurochem 115:526-536.
18. Gresa-Arribas N, Viéitez C, Serratosa J, Saura J, Solà C. 2012. Modelling neuroinflammation in vitro: A tool to test the potential neuroprotective effect of anti-inflammatory agents. PLos One 7:e45227.
19. Gurley C, Nichols J, Liu S, Phulwani NK, Esen N, Kielian T. 2008. Microglia and astrocyte activation by toll-like receptor ligands: Modulation by PPAR-γ agonists. PPAR Res 2008:453120.
20. Hanisch UK, Kettenmann H. 2007. Microglia: Active sensor and versatile effector cells in the normal and pathologic brain. Nature Neurosci 10:1387-1394.
21. Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE. 2005. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 128:1442-1453.
22. Hernangómez M, Mestre L, Correa FG, Loría F, Mecha M, Iñigo PM, Docagne F, Williams RO, Borrell J, Guaza C. 2012. CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation. Glia 60:1437-1450.
23. Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, Blom B, Homola ME, Streit WJ, Brown MH, Barclay AN, Sedgwick JD. 2000. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290:1768-1771.
24. Janabi N. 2002. Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12-14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages. J Immunol 168:4747-4755.
25. Kapadia R, Yi JH, Vemuganti R. 2009. Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci 13:1813-1826.
26. 2 inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-γ and heme oxygenase-1 in rat hippocampal slices. J Neurosci Res 90:1732-1742.
27. Koning N, Bö L, Hoek RM, Huitinga I. 2007. Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann Neurol 62:504-514.
28. Koning N, Swaab DF, Hoek RM, Huitinga I. 2009. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggested neuron-glia and glia-glia interactions. J Neuropathol Exp Neurol 68:159-167.
29. Koning N, van Eijk M, Pouwels W, Brouwer MS, Voheringer D, Huitinga I, Hoek RM, Raes G, Hamann J. 2010. Expression of the inhibitory CD200 receptor is associated with alternative macrophage activation. J Innate Immun 2:195-200.
30. 2 acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. Brain Res 867:115-121.
31. Lee JH, Woo JH, Woo SU, Kim KS, Park SM, Joe EH, Jou I. 2008. The 15-deoxy-delta 12, 14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. J Immunol 181:8642-8649.
32. Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG. 2002. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41:6640-6650.
33. Liu Y, Bando Y, Vargas-Lowy D, Elyaman W, Khoury SJ, Huang T, Reif K, Chitnis T. 2010. CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis. J Neurosci 30:2025-2038.
34. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methods 25:402-408.
35. Luna-Medina R, Cortes-Canteli M, Alonso M, Santos A, Martínez A, Perez-Castillo A. 2005. Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor γ activation. J Biol Chem 280:21453-21462.
36. Lyons A, Downer EJ, Costello DA, Murphy N, Lynch MA. 2012. Dok2 mediates the CD200Fc attenuation of Abeta-induced changes in glia. J Neuroinflammation 9:107.
37. Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA. 2007. CD200 ligand-receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4. J Neurosci 27:8309-8313.
38. Meuth SG, Simon OJ, Grimm A, Melzer N, Herrmann AM, Spitzer P, Landgraf P Wiendl H. 2008. CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing. J Neuroimmunol 194:62-69.
39. Natarajan C, Bright JJ. 2002. Peroxisome proliferator-activated receptor-γ agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes Immun 3:59-70.
40. 2 and rosiglitazone suppress janus kinase-STAT inflammatory signalling through induction of suppressor of cytokine signalling 1 (SOCS1) and SOCS3 in glia. J Biol Chem 278:14747-14752.
41. Patzer A, Zhao Y, Stöck I, Gohlke P, Herdegen T, Culman J. 2008. Peroxisome proliferator-activated receptors gamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. Eur J Neurosci 28:1786-1794.
42. 2. Proc Natl Acad Sci USA 96:4668-4673.
43. Phulwani NK, Feinstein DL, Gavrilyuk V, Akar C, Kielian T. 2006. 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. J Neurochem 99:1389-1402.
44. Ransohoff RM, Cardona AE. 2010. The myeloid cells of the central nervous system parenchyma. Nature 468:253-262.
45. Ricote M, Glass CK. 2007. PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta 1771:926-935.
46. Saura J, Tusell JM, Serratosa J. 2003. High-yield isolation of murine microglia by mild trypsinization. Glia 44:183-189.
47. Schintu N, Frau L, Ibba M, Caboni P, Garau A, Carboni E, Carta AR. 2009. PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease. Eur J Neurosci 29:954-63.
48. Schütz B, Reimann J, Dumitrescu-Ozimek L, Kappes-Horn K, Landreth GE, Schürmann B, Zimmer A, Heneka MT. 2005. The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. J Neurosci 25:7805-7812.
49. Storer PD, Xu J, Chavis J, Drew PD. 2005. Peroxisome-proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astocytes: Implications for multiple sclerosis. J Neuroimmunol 161:113-122.
50. Tian L, Rauvala H, Gahmberg CG. 2009. Neuronal regulation of immune responses in the central nervous system. Trends Immunol 30:91-99.
51. Tureyen K, Kapadia R, Bowen KK, Satriotomo I, Liang J, Feinstein DL, Vemuganti R. 2007. Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J Neurochem 101:41-56.
52. Walker DG, Dalsing-Hernandez JE, Campbell NA, Lue L-F. 2009. Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation. Exp Neurol 215:5-19.
53. Wang XJ, Ye M, Zhang YH, Chen SD. 2007. CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease. J Neuroimmune Pharmacol 2:259-264.
54. Wang XJ, Zhang S, Yan ZQ, Zhao YX, Zhou HY, Wang Y, Lu GQ, Zhang JD. 2011. Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase and p38 MAPK. Free Radic Biol Med 50:1094-1106.
55. Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK. 2003. PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages. Proc Natl Acad Sci USA 100:6712-6717.
56. Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, Spiegelman BM. 2000a. A synthetic sntagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. J Biol Chem 275:1873-1877.
57. Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AM. 2000b. Lymphoid/neuronal cell surface glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13:233-242.
58. Xing B, Xin T, Hunter RL, Bing G. 2008. Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. J Neuroinflammation 5:4.
59. Xu J, Drew PD. 2007. Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. J Immunol 178:1904-1913.
60. Zhang S, Wang XJ, Tian LP, Pan J, Lu GQ, Zhang YJ, Ding JQ, Chen SD. 2011. CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease. J Neuroinflammation 8:154.