T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 14, 2014, Pages 5295-5300

  Inoue, Makoto ^a   Arikawa, Tomohiro ^a,b   Chen, Yu Hsun ^a   Moriwaki, Yasuhiro ^a,c   Price, Michael ^a   Brown, Michael ^a   Perfect, John R ^a   Shinohara, Mari L ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

CD154; CD40L; OPN; Simultaneous stimulation; T cell migration

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 10; MESSENGER RNA; OSTEOPONTIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; EX VIVO STUDY; FEMALE; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; LYMPHOCYTE FUNCTION; MACROPHAGE; MACROPHAGE CULTURE; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPLEEN; SUMOYLATION; T LYMPHOCYTE;

CD154; CD40L; OPN; SIMULTANEOUS STIMULATION; T CELL MIGRATION;

ANIMALS; ANTIGENS, CD; CELL NUCLEUS; DOWN-REGULATION; INFLAMMATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-10; MACROPHAGES; MICE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SUMOYLATION; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84898020246     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321427111     Document Type: Article

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