메뉴 건너뛰기




Volumn 4, Issue 2, 2014, Pages 85-94

MicroRNAs of parasitic helminths - Identification, characterization and potential as drug targets

Author keywords

Caenorhabditis elegans; Gene regulation; Helminth; MicroRNAs; Parasite; Therapeutic

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FLUORESCENT DYE; HELMINTH RNA; IVERMECTIN; MICRORNA; MICRORNA 122; MIRAVIRSEN; PYRANTEL; SMALL INTERFERING RNA;

EID: 84898013724     PISSN: 22113207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpddr.2014.03.001     Document Type: Review
Times cited : (63)

References (89)
  • 1
    • 84863493254 scopus 로고    scopus 로고
    • Characterization of microRNAs in Taenia saginata of zoonotic significance by Solexa deep sequencing and bioinformatic analysis
    • Ai L., Xu M.J., Chen M.X., Zhang Y.N., Chen S.H., Guo J., Cai Y.C., Zhou X.N., Zhu X.Q., Chen J.X. Characterization of microRNAs in Taenia saginata of zoonotic significance by Solexa deep sequencing and bioinformatic analysis. Parasitol. Res. 2012, 110:2373-2378.
    • (2012) Parasitol. Res. , vol.110 , pp. 2373-2378
    • Ai, L.1    Xu, M.J.2    Chen, M.X.3    Zhang, Y.N.4    Chen, S.H.5    Guo, J.6    Cai, Y.C.7    Zhou, X.N.8    Zhu, X.Q.9    Chen, J.X.10
  • 2
    • 76749134307 scopus 로고    scopus 로고
    • Many families of C. elegans microRNAs are not essential for development or viability
    • Alvarez-Saavedra E., Horvitz H.R. Many families of C. elegans microRNAs are not essential for development or viability. Curr. Biol. 2010, 20:367-373.
    • (2010) Curr. Biol. , vol.20 , pp. 367-373
    • Alvarez-Saavedra, E.1    Horvitz, H.R.2
  • 3
    • 0021771445 scopus 로고
    • Heterochronic mutants of the nematode Caenorhabditis elegans
    • Ambros V., Horvitz H.R. Heterochronic mutants of the nematode Caenorhabditis elegans. Science 1984, 226:409-416.
    • (1984) Science , vol.226 , pp. 409-416
    • Ambros, V.1    Horvitz, H.R.2
  • 4
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 5
    • 38749105426 scopus 로고    scopus 로고
    • P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles
    • Blackhall W.J., Prichard R.K., Beech R.N. P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles. Vet. Parasitol. 2008, 152:101-107.
    • (2008) Vet. Parasitol. , vol.152 , pp. 101-107
    • Blackhall, W.J.1    Prichard, R.K.2    Beech, R.N.3
  • 6
    • 78649325763 scopus 로고    scopus 로고
    • Serum microRNAs as non-invasive biomarkers for cancer
    • Brase J.C., Wuttig D., Kuner R., Sultmann H. Serum microRNAs as non-invasive biomarkers for cancer. Mol. Cancer 2010, 9:306.
    • (2010) Mol. Cancer , vol.9 , pp. 306
    • Brase, J.C.1    Wuttig, D.2    Kuner, R.3    Sultmann, H.4
  • 7
    • 77957756295 scopus 로고    scopus 로고
    • Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegans
    • Brenner J.L., Jasiewicz K.L., Fahley A.F., Kemp B.J., Abbott A.L. Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegans. Curr. Biol. 2010, 20:1321-1325.
    • (2010) Curr. Biol. , vol.20 , pp. 1321-1325
    • Brenner, J.L.1    Jasiewicz, K.L.2    Fahley, A.F.3    Kemp, B.J.4    Abbott, A.L.5
  • 9
    • 84877783095 scopus 로고    scopus 로고
    • A deep analysis of the small non-coding RNA population in Schistosoma japonicum eggs
    • Cai P., Piao X., Hao L., Liu S., Hou N., Wang H., Chen Q. A deep analysis of the small non-coding RNA population in Schistosoma japonicum eggs. PLoS One 2013, 8:e64003.
    • (2013) PLoS One , vol.8
    • Cai, P.1    Piao, X.2    Hao, L.3    Liu, S.4    Hou, N.5    Wang, H.6    Chen, Q.7
  • 10
    • 84883687852 scopus 로고    scopus 로고
    • Identification and characterisation of microRNAs in young adults of Angiostrongylus cantonensis via a deep-sequencing approach
    • Chang S.H., Tang P., Lai C.H., Kuo M.L., Wang L.C. Identification and characterisation of microRNAs in young adults of Angiostrongylus cantonensis via a deep-sequencing approach. Mem. Inst. Oswaldo Cruz 2013, 108:699-706.
    • (2013) Mem. Inst. Oswaldo Cruz , vol.108 , pp. 699-706
    • Chang, S.H.1    Tang, P.2    Lai, C.H.3    Kuo, M.L.4    Wang, L.C.5
  • 11
    • 66049133419 scopus 로고    scopus 로고
    • Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
    • Chekulaeva M., Filipowicz W. Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Curr. Opin. Cell Biol. 2009, 21:452-460.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 452-460
    • Chekulaeva, M.1    Filipowicz, W.2
  • 12
  • 15
    • 79951809730 scopus 로고    scopus 로고
    • Identification of Echinococcus granulosus microRNAs and their expression in different life cycle stages and parasite genotypes
    • Cucher M., Prada L., Mourglia-Ettlin G., Dematteis S., Camicia F., Asurmendi S., Rosenzvit M. Identification of Echinococcus granulosus microRNAs and their expression in different life cycle stages and parasite genotypes. Int. J. Parasitol. 2011, 41:439-448.
    • (2011) Int. J. Parasitol. , vol.41 , pp. 439-448
    • Cucher, M.1    Prada, L.2    Mourglia-Ettlin, G.3    Dematteis, S.4    Camicia, F.5    Asurmendi, S.6    Rosenzvit, M.7
  • 17
    • 79960699368 scopus 로고    scopus 로고
    • Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni
    • de Souza Gomes M., Muniyappa M.H., Carvalho S.G., Guerra-Sa R., Spillane C. Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics 2011, 98:96-111.
    • (2011) Genomics , vol.98 , pp. 96-111
    • de Souza Gomes, M.1    Muniyappa, M.H.2    Carvalho, S.G.3    Guerra-Sa, R.4    Spillane, C.5
  • 18
    • 70350705948 scopus 로고    scopus 로고
    • Repertoire and evolution of miRNA genes in four divergent nematode species
    • de Wit E., Linsen S.E.V., Cuppen E., Berezikov E. Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res. 2009, 19:2064-2074.
    • (2009) Genome Res. , vol.19 , pp. 2064-2074
    • de Wit, E.1    Linsen, S.E.V.2    Cuppen, E.3    Berezikov, E.4
  • 20
    • 77955920974 scopus 로고    scopus 로고
    • MicroRNAs: a role in drug resistance in parasitic nematodes
    • Devaney E., Winter A.D., Britton C. MicroRNAs: a role in drug resistance in parasitic nematodes. Trends Parasitol. 2010, 26:428-433.
    • (2010) Trends Parasitol. , vol.26 , pp. 428-433
    • Devaney, E.1    Winter, A.D.2    Britton, C.3
  • 21
    • 78149303249 scopus 로고    scopus 로고
    • MicroRNA sponges: progress and possibilities
    • Ebert M.S., Sharp P.A. MicroRNA sponges: progress and possibilities. RNA 2010, 16:2043-2050.
    • (2010) RNA , vol.16 , pp. 2043-2050
    • Ebert, M.S.1    Sharp, P.A.2
  • 23
    • 84855293838 scopus 로고    scopus 로고
    • MiRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
    • Friedländer M.R., Mackowiak S.D., Li N., Chen W., Rajewsky N. MiRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res. 2012, 40:37-52.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 37-52
    • Friedländer, M.R.1    Mackowiak, S.D.2    Li, N.3    Chen, W.4    Rajewsky, N.5
  • 24
    • 79954687738 scopus 로고    scopus 로고
    • Intralocus sexual conflict resolved through gene duplication
    • Gallach M., Betran E. Intralocus sexual conflict resolved through gene duplication. Trends Ecol. Evol. 2011, 26:222-228.
    • (2011) Trends Ecol. Evol. , vol.26 , pp. 222-228
    • Gallach, M.1    Betran, E.2
  • 26
    • 34648836102 scopus 로고    scopus 로고
    • Draft genome of the filarial nematode parasite Brugia malayi
    • Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., et al. Draft genome of the filarial nematode parasite Brugia malayi. Science 2007, 317:1756-1760.
    • (2007) Science , vol.317 , pp. 1756-1760
    • Ghedin, E.1    Wang, S.2    Spiro, D.3    Caler, E.4    Zhao, Q.5
  • 32
    • 50849141708 scopus 로고    scopus 로고
    • MirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts
    • Hammell M., Long D., Zhang L., Lee A., Carmack C.S., Han M., Ding Y., Ambros V. MirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nat. Methods 2008, 5:813-819.
    • (2008) Nat. Methods , vol.5 , pp. 813-819
    • Hammell, M.1    Long, D.2    Zhang, L.3    Lee, A.4    Carmack, C.S.5    Han, M.6    Ding, Y.7    Ambros, V.8
  • 33
    • 74549165574 scopus 로고    scopus 로고
    • The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease
    • Harnett M.M., Melendez A.J., Harnett W. The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clin. Exp. Immunol. 2010, 159:256-267.
    • (2010) Clin. Exp. Immunol. , vol.159 , pp. 256-267
    • Harnett, M.M.1    Melendez, A.J.2    Harnett, W.3
  • 34
    • 67650355471 scopus 로고    scopus 로고
    • Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity
    • Hewitson J.P., Grainger J.R., Maizels R.M. Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. Mol. Biochem. Parasitol. 2009, 167:1-11.
    • (2009) Mol. Biochem. Parasitol. , vol.167 , pp. 1-11
    • Hewitson, J.P.1    Grainger, J.R.2    Maizels, R.M.3
  • 36
    • 84864382291 scopus 로고    scopus 로고
    • Extracellular small RNAs: what, where and why?
    • Hoy A.M., Buck A.H. Extracellular small RNAs: what, where and why?. Biochem. Soc. Trans. 2012, 40:886-890.
    • (2012) Biochem. Soc. Trans. , vol.40 , pp. 886-890
    • Hoy, A.M.1    Buck, A.H.2
  • 38
    • 77949526665 scopus 로고    scopus 로고
    • Genome-wide identification of Schistosoma japonicum microRNAs using a deep sequencing approach
    • Huang J., Hao P., Chen H., Hu W., Yan Q., Liu F., Han Z.-G. Genome-wide identification of Schistosoma japonicum microRNAs using a deep sequencing approach. PLoS One 2009, 4:e8206.
    • (2009) PLoS One , vol.4
    • Huang, J.1    Hao, P.2    Chen, H.3    Hu, W.4    Yan, Q.5    Liu, F.6    Han, Z.-G.7
  • 42
    • 0347357618 scopus 로고    scopus 로고
    • A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans
    • Johnston R.J., Hobert O. A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature 2003, 426:845-849.
    • (2003) Nature , vol.426 , pp. 845-849
    • Johnston, R.J.1    Hobert, O.2
  • 43
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA
    • Jopling C.L., Yi M., Lancaster A.M., Lemon S.M., Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 2005, 309:1577-1581.
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 44
    • 67649663873 scopus 로고    scopus 로고
    • Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development
    • Kato M., de Lencastre A., Pincus Z., Slack F.J. Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol. 2009, 10:R54.
    • (2009) Genome Biol. , vol.10
    • Kato, M.1    de Lencastre, A.2    Pincus, Z.3    Slack, F.J.4
  • 46
    • 58849142908 scopus 로고    scopus 로고
    • Acetylcholine receptor subunit genes from Ancylostoma caninum: altered transcription patterns associated with pyrantel resistance
    • Kopp S.R., Coleman G.T., Traub R.J., McCarthy J.S., Kotze A.C. Acetylcholine receptor subunit genes from Ancylostoma caninum: altered transcription patterns associated with pyrantel resistance. Int. J. Parasitol. 2009, 39:435-441.
    • (2009) Int. J. Parasitol. , vol.39 , pp. 435-441
    • Kopp, S.R.1    Coleman, G.T.2    Traub, R.J.3    McCarthy, J.S.4    Kotze, A.C.5
  • 47
    • 84861459438 scopus 로고    scopus 로고
    • Systematic analysis of tissue-restricted miRISCs reveals a broad role for microRNAs in suppressing basal activity of the C. elegans pathogen response
    • Kudlow B.A., Zhang L., Han M. Systematic analysis of tissue-restricted miRISCs reveals a broad role for microRNAs in suppressing basal activity of the C. elegans pathogen response. Mol. Cell 2012, 46:530-541.
    • (2012) Mol. Cell , vol.46 , pp. 530-541
    • Kudlow, B.A.1    Zhang, L.2    Han, M.3
  • 48
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 49
    • 78649378267 scopus 로고    scopus 로고
    • MicroRNA functions in stress responses
    • Leung A.K.L., Sharp P.A. MicroRNA functions in stress responses. Mol. Cell 2010, 40:205-215.
    • (2010) Mol. Cell , vol.40 , pp. 205-215
    • Leung, A.K.L.1    Sharp, P.A.2
  • 55
    • 40849098017 scopus 로고    scopus 로고
    • DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans
    • Miyata S., Begun J., Troemel E.R., Ausubel F.M. DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics 2008, 178:903-918.
    • (2008) Genetics , vol.178 , pp. 903-918
    • Miyata, S.1    Begun, J.2    Troemel, E.R.3    Ausubel, F.M.4
  • 57
    • 84873732487 scopus 로고    scopus 로고
    • The hookworm pharmacopoeia for inflammatory diseases
    • Navarro S., Ferreira I., Loukas A. The hookworm pharmacopoeia for inflammatory diseases. Int. J. Parasitol. 2013, 43:225-231.
    • (2013) Int. J. Parasitol. , vol.43 , pp. 225-231
    • Navarro, S.1    Ferreira, I.2    Loukas, A.3
  • 58
    • 79952186298 scopus 로고    scopus 로고
    • MicroRNAs: the fine tuners of Toll-like receptor signalling
    • O'Neill L.A., Sheedy F.J., McCoy C.E. MicroRNAs: the fine tuners of Toll-like receptor signalling. Nat. Rev. Immunol. 2011, 11:163-175.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 163-175
    • O'Neill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 59
    • 33748133008 scopus 로고    scopus 로고
    • MicroRNAs from the planarian Schmidtea mediterranea: a model system for stem cell biology
    • Palakodeti D., Smielewska M., Graveley B.R. MicroRNAs from the planarian Schmidtea mediterranea: a model system for stem cell biology. RNA 2006, 12:1640-1649.
    • (2006) RNA , vol.12 , pp. 1640-1649
    • Palakodeti, D.1    Smielewska, M.2    Graveley, B.R.3
  • 60
    • 66849113786 scopus 로고    scopus 로고
    • MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells
    • Pan Y.Z., Morris M.E., Yu A.M. MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. Mol. Pharmacol. 2009, 75:1374-1379.
    • (2009) Mol. Pharmacol. , vol.75 , pp. 1374-1379
    • Pan, Y.Z.1    Morris, M.E.2    Yu, A.M.3
  • 61
    • 71949087432 scopus 로고    scopus 로고
    • Cloning and bioinformatic identification of small RNAs in the filarial nematode, Brugia malayi
    • Poole C.B., Davis P.J., Jin J.M., McReynolds L.A. Cloning and bioinformatic identification of small RNAs in the filarial nematode, Brugia malayi. Mol. Biochem. Parasitol. 2010, 169:87-94.
    • (2010) Mol. Biochem. Parasitol. , vol.169 , pp. 87-94
    • Poole, C.B.1    Davis, P.J.2    Jin, J.M.3    McReynolds, L.A.4
  • 62
    • 34347399591 scopus 로고    scopus 로고
    • ABC transporters and beta-tubulin in macrocyclic lactone resistance: prospects for marker development
    • Prichard R.K., Roulet A. ABC transporters and beta-tubulin in macrocyclic lactone resistance: prospects for marker development. Parasitology 2007, 134:1123-1132.
    • (2007) Parasitology , vol.134 , pp. 1123-1132
    • Prichard, R.K.1    Roulet, A.2
  • 63
    • 64149091885 scopus 로고    scopus 로고
    • *) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance
    • *) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance. Mol. Biochem. Parasitol. 2009, 166:54-61.
    • (2009) Mol. Biochem. Parasitol. , vol.166 , pp. 54-61
    • Rao, V.T.1    Siddiqui, S.Z.2    Prichard, R.K.3    Forrester, S.G.4
  • 67
    • 77952308587 scopus 로고    scopus 로고
    • Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance
    • Rouhana L., Shibata N., Nishimura O., Agata K. Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance. Dev. Biol. 2010, 341:429-443.
    • (2010) Dev. Biol. , vol.341 , pp. 429-443
    • Rouhana, L.1    Shibata, N.2    Nishimura, O.3    Agata, K.4
  • 68
    • 33845436047 scopus 로고    scopus 로고
    • Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
    • Ruby J.G., Jan C., Player C., Axtell M.J., Lee W., Nusbaum C., Ge H., Bartel D.P. Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell 2006, 127:1193-1207.
    • (2006) Cell , vol.127 , pp. 1193-1207
    • Ruby, J.G.1    Jan, C.2    Player, C.3    Axtell, M.J.4    Lee, W.5    Nusbaum, C.6    Ge, H.7    Bartel, D.P.8
  • 69
    • 84866392767 scopus 로고    scopus 로고
    • Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo
    • Rückerl D., Jenkins S.J., Laqtom N.N., Gallagher I.J., Sutherland T.E., Duncan S., Buck A.H., Allen J.E. Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo. Blood 2012, 120:2307-2316.
    • (2012) Blood , vol.120 , pp. 2307-2316
    • Rückerl, D.1    Jenkins, S.J.2    Laqtom, N.N.3    Gallagher, I.J.4    Sutherland, T.E.5    Duncan, S.6    Buck, A.H.7    Allen, J.E.8
  • 70
    • 0024976940 scopus 로고
    • The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch
    • Ruvkun G., Giusto J. The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature 1989, 338:313-319.
    • (1989) Nature , vol.338 , pp. 313-319
    • Ruvkun, G.1    Giusto, J.2
  • 74
    • 84885150806 scopus 로고    scopus 로고
    • Epigenetic regulation in adult stem cells and cancer
    • Tarayrah L., Chen X. Epigenetic regulation in adult stem cells and cancer. Cell Biosci. 2013, 3:41.
    • (2013) Cell Biosci. , vol.3 , pp. 41
    • Tarayrah, L.1    Chen, X.2
  • 76
    • 38049030287 scopus 로고    scopus 로고
    • Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock
    • Tili E., Michaille J.J., Cimino A., Costinean S., Dumitru C.D., Adair B., Fabbri M., Alder H., Liu C.G., Calin G.A., Croce C.M. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock. J. Immunol. 2007, 179:5082-5089.
    • (2007) J. Immunol. , vol.179 , pp. 5082-5089
    • Tili, E.1    Michaille, J.J.2    Cimino, A.3    Costinean, S.4    Dumitru, C.D.5    Adair, B.6    Fabbri, M.7    Alder, H.8    Liu, C.G.9    Calin, G.A.10    Croce, C.M.11
  • 80
    • 80052521105 scopus 로고    scopus 로고
    • Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles
    • Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J., Davis R.E. Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Res. 2011, 21:1462-1477.
    • (2011) Genome Res. , vol.21 , pp. 1462-1477
    • Wang, J.1    Czech, B.2    Crunk, A.3    Wallace, A.4    Mitreva, M.5    Hannon, G.J.6    Davis, R.E.7
  • 81
  • 82
    • 84873733555 scopus 로고    scopus 로고
    • Translatability of helminth therapy in inflammatory bowel diseases
    • Weinstock J.V., Elliott D.E. Translatability of helminth therapy in inflammatory bowel diseases. Int. J. Parasitol. 2013, 43:245-251.
    • (2013) Int. J. Parasitol. , vol.43 , pp. 245-251
    • Weinstock, J.V.1    Elliott, D.E.2
  • 83
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B., Ha I., Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993, 75:855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 87
    • 71049182620 scopus 로고    scopus 로고
    • Role of microRNAs in the regulation of drug metabolism and disposition
    • Yu A.M. Role of microRNAs in the regulation of drug metabolism and disposition. Exp. Opin. Drug Metab. Toxicol. 2009, 5:1513-1528.
    • (2009) Exp. Opin. Drug Metab. Toxicol. , vol.5 , pp. 1513-1528
    • Yu, A.M.1
  • 88
    • 70350038073 scopus 로고    scopus 로고
    • Systematic analysis of dynamic miRNA-target interactions during C. elegans development
    • Zhang L., Hammell M., Kudlow B.A., Ambros V., Han M. Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development 2009, 136:3043-3055.
    • (2009) Development , vol.136 , pp. 3043-3055
    • Zhang, L.1    Hammell, M.2    Kudlow, B.A.3    Ambros, V.4    Han, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.