Host immune system gene targeting by a viral miRNA

Science

Volumn 317, Issue 5836, 2007, Pages 376-381

  Stern Ginossar, Noam ^a   Elefant, Naama ^a   Zimmermann, Albert ^b   Wolf, Dana G ^c   Saleh, Nivin ^c   Biton, Moshe ^a   Horwitz, Elad ^a   Prokocimer, Zafnat ^a   Prichard, Mark ^d   Hahn, Gabriele ^e,f   Goldman Wohl, Debra ^c   Greenfield, Caryn ^c   Yagel, Simcha ^c   Hengel, Hartmut ^b   Altuvia, Yael ^a   Margalit, Hanah ^a   Mandelboim, Ofer ^a  

^a HEBREW UNIVERSITY   (Israel)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d University of Alabama at Birmingham   (United States)

^e UNIVERSITY OF MUNICH   (Germany)

^f KLINIKUM INGOLSTADT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MICRORNA; NATURAL KILLER CELL RECEPTOR NKG2D; VIRUS RNA;

ALGORITHM; GENE; HISTOPATHOLOGY; HOST; IMMUNE SYSTEM; RNA; TUMOR; VIRUS;

ALGORITHM; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNOPATHOGENESIS; IMMUNOREGULATION; NATURAL KILLER CELL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS PATHOGENESIS;

3' UNTRANSLATED REGIONS; ALGORITHMS; BINDING SITES; CELL LINE, TUMOR; CELLS, CULTURED; CYTOMEGALOVIRUS; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; LIGANDS; MICRORNAS; RECEPTORS, IMMUNOLOGIC; RNA, VIRAL; TRANSDUCTION, GENETIC;

HUMAN HERPESVIRUS 5;

EID: 34547132780     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140956     Document Type: Article

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20. We thank D. Cosman for the NKG2D-Ig and C. Sinzger for bacterial artificial chromosome plasmid pTB40 reagent; T. Tuschl, S. Altuvia, and D. M. Davis for useful discussions; R. Melnikov for technical support; and E. Akiva and G. Lithwick for their useful comments on the manuscript. This study was supported by grants from the U.S.-Israel Binational Science Foundation (H.M. and O.M.), the Israeli Cancer Research Foundation (H.M. and O.M.), the Israeli Science Foundation (O.M.), the European Consortium (grant nos. MRTN-CT-2005 and LSCH-CT-2005-518178, O.M.), the Hadassah Women's Health Fund (S.Y.), the Deutsche Forschungsgemeinschaft (grant HE 2S26/7-1, H.H.), and the National Institute for Allergy and Infectious Disease (grant no. N01-30049, M.P.).