Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 8, 2014, Pages 2535-2541

  Yan, Zi Hong ^a   Huang, Xia Yun ^a   Wu, Hai Qiu ^a   Chen, Wen Xue ^a   He, Qiu Qin ^a   Chen, Fen Er ^a   De Clercq, Erik ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral activity; Diarylpyrimidine; HIV 1; NNRTIs; SAR

Indexed keywords

4 [[4 (1 HYDROXY 1 PHENYLETHYL)PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (3 BROMOPHENYL) 1 HYDROXYETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (3 CHLOROPHENYL) 1 HYDROXYETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (3 FLUOROPHENYL) 1 HYDROXYETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (4 BROMOPHENYL) 1 HYDROXYALLYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (4 BROMOPHENYL) 1 HYDROXYETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (4 BROMOPHENYL) 1 HYDROXYPROPYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (4 CHLOROPHENYL) 1 HYDROXYETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (4 FLUOROPHENYL) 1 HYDROXYETHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (4 FLUOROPHENYL) 1 HYDROXYETHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 (4 FLUOROPHENYL) 1 HYDROXYETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 HYDROXY 1 (4 METHOXYPHENYL)ETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 HYDROXY 1 (NAPHTHALEN 1 YL)ETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 HYDROXY 1 (TOLYL)ETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 [4 (TERT BUTYL)PHENYL] 1 HYDROXYETHYL] 5 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 [4 (TERT BUTYL)PHENYL] 1 HYDROXYETHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [1 [4 (TERT BUTYL)PHENYL] 1 YDROXYETHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [[4 BROMOPHENYL](CYCLOPROPYL)(HYDROXY)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; ANTIVIRUS AGENT; DELAVIRDINE; DIARYLPYRIMIDINE DERIVATIVES; EFAVIRENZ; ETRAVIRINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WILD TYPE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL LINE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BINDING SITES; CELL LINE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898009212     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.02.030     Document Type: Article

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