Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 12, 2012, Pages 3856-3864

  Liu, Xin ^a   Liu, Xinyong ^a   Chen, Xuwang ^a   Zhan, Peng ^a   Cheng, Ziheng ^b   Meng, Caicai ^a   Shao, Siyuan ^a   Pannecouque, Christophe ^c   De Clercq, Erik ^c  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral activity; HIV 1; Molecular modeling; NNRTIs; Piperidine; SAR; Triazine

Indexed keywords

4 [[4 [4 (MESITYLAMINO) 6 (METHYLAMINO) 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZAMIDE; 4 [[4 [4 (MESITYLAMINO) 6 (METHYLAMINO) 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZENESULFONAMIDE; 4 [[4 [4 (MESITYLAMINO) 6 METHOXY 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZAMIDE; 4 [[4 [4 (MESITYLAMINO) 6 METHOXY 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZENESULFONAMIDE; 4 [[4 [4 AMINO 6( MESITYLAMINO) 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZAMIDE; 4 [[4 [4 AMINO 6( MESITYLAMINO) 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZENESULFONAMIDE; 4 [[4 [4 AMINO 6( MESITYLAMINO) 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZONITRILE; DELAVIRDINE; EFAVIRENZ; ETHYL 4 [[4 [4 (MESITYLAMINO) 6 (METHYLAMINO) 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZOIC ACID; ETHYL 4 [[4 [4 (MESITYLAMINO) 6 METHOXY 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZOIC ACID; ETHYL 4 [[4 [4 AMINO 6 (MESITYLAMINO) 1,3,5 TRIAZIN 2 YLAMINO]PIPERIDIN 1 YL]METHYL]BENZOIC ACID; ETRAVIRINE; N2 (1 BENZYLPIPERIDIN 4 YL) N4 MESITYL 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N2 MESITYL 6 METHOXY N4 [1 (PYRIDIN 4 YLMETHYL)PIPERIDIN 4 YL] 1,3,5 TRIAZINE 2,4 DIAMINE; N2 MESITYL 6 METHOXY N4 [1 [4 (METHYLSULFONYL)BENZYL]PIPERIDIN 4 YL] 1,3,5 TRIAZINE 2,4 DIAMINE; N2 MESITYL N4 [1 (4 NITROBENZYL)PIPERIDIN 4 YL] 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N2 MESITYL N4 [1 (PYRIDIN 4 YLMETHYL)PIPERIDIN 4 YL] 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N2 MESITYL N4 [1 [4 (METHYLSULFONYL)BENZYL]PIPERIDIN 4 YL] 1,3,5 TRIAZINE 2,4,6 TRIAMINE; N2 MESITYL N4 METHYL N6 [1 (PYRIDIN 4 YLMETHYL)PIPERIDIN 4 YL] 1,3,5 TRIAZINE 2,4,6 TRIAMINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PIPERIDINE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

AMINES; ANTI-HIV AGENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HIV REVERSE TRANSCRIPTASE; HIV-1; HIV-2; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84861575661     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.030     Document Type: Conference Paper

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