Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 633-642

  Zhang, Lingzi ^a   Zhan, Peng ^a   Chen, Xuwang ^a   Li, Zhenyu ^a   Xie, Zhoumeng ^a   Zhao, Tong ^a   Liu, Huiqing ^a   De Clercq, Erik ^b   Pannecouque, Christophe ^b   Balzarini, Jan ^b   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

AIDS; Anti HIV 1 activity; HIV 1; NNRTIs; Synthesis

Indexed keywords

1 [4 [[4 [5 (MESITYLOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]PHENYL]ETHANONE; 1 BENZYL N [5 (MESITYLOXY) 2 NITROPHENYL]PIPERIDIN 4 AMINE; 3,5 DIMETHYL 4 [3 [1 [4 (METHYLSULFONYL)BENZYL]PIPERIDIN 4 YLAMINO] 4 NITROPHENOXY]BENZONITRILE; 3,5 DIMETHYL 4 [4 NITRO 3 [1 (4 NITROBENZYL)PIPERIDIN 4 YLAMINO]PHENOXY]BENZONITRILE; 3,5 DIMETHYL 4 [4 NITRO 3 [1 (PYRIDIN 4 YLMETHYL)PIPERIDIN 4 YLAMINO]PHENOXY]BENZONITRILE; 4 [3 (1 BENZYLPIPERIDIN 4 YLAMINO) 4 NITROPHENOXY] 3,5 DIMETHYLBENZONITRILE; 4 [3 [1 (4 ACETYLBENZYL)PIPERIDIN 4 YLAMINO] 4 NITROPHENOXY] 3,5 DIMETHYLBENZONITRILE; 4 [3 [1 [4 (HYDROXYMETHYL)BENZYL]PIPERIDIN 4 YLAMINO] 4 NITROPHENOXY] 3,5 DIMETHYLBENZONITRILE; 4 [[4 [2 AMINO 5 (4 CYANO 2,6 DIMETHYLPHENOXY)PHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZENESULFONAMIDE; 4 [[4 [5 (4 CYANO 2,6 DIMETHYLPHENOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZAMIDE; 4 [[4 [5 (4 CYANO 2,6 DIMETHYLPHENOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZENESULFONAMIDE; 4 [[4 [5 (4 CYANO 2,6 DIMETHYLPHENOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZOIC ACID; 4 [[4 [5 (MESITYLOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZAMIDE; 4 [[4 [5 (MESITYLOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZENESULFONAMIDE; 4 [[4 [5 (MESITYLOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZOIC ACID; [4 [[4 [5 (MESITYLOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]PHENYL]METHANOL; ANILINE DERIVATIVE; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; METHYL 4 [[4 [5 (4 CYANO 2,6 DIMETHYLPHENOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZOATE; METHYL 4 [[4 [5 (MESITYLOXY) 2 NITROPHENYLAMINO]PIPERIDIN 1 YL]METHYL]BENZOATE; N [4 (4 CYANO 2,6 DIMETHYLPHENOXY) 2 [1 (4 SULFAMOYLBENZYL)PIPERIDIN 4-YLAMINO]PHENYL]ACETAMIDE; N [5 (MESITYLOXY) 2 NITROPHENYL] 1 (4 NITROBENZYL)PIPERIDIN 4 AMINE; N [5 (MESITYLOXY) 2 NITROPHENYL] 1 (PYRIDIN 4 YLMETHYL)PIPERIDIN 4 AMINE; N [5 (MESITYLOXY) 2 NITROPHENYL] 1 [4 (METHYLSULFONYL)BENZYL]PIPERIDIN 4 AMINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AIDS; ANTI-HIV-1 ACTIVITY; HIV-1; NNRTIS; SYNTHESIS;

ANILINE COMPOUNDS; ANTI-HIV AGENTS; DRUG DESIGN; HIV-1; HUMANS; MODELS, MOLECULAR; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891492069     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.10.033     Document Type: Article

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