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Volumn 11, Issue 4, 2014, Pages 1208-1217

99mTc-labeled cystine knot peptide targeting integrin αvβ6 for tumor SPECT imaging

Author keywords

cystine knot peptide; SPECT

Indexed keywords

ALPHAVBETA6 INTEGRIN; RADIOPHARMACEUTICAL AGENT; SINGLE AMINO ACID CHELATE CYSTINE KNOT PEPTIDE TC 99M; UNCLASSIFIED DRUG; INTEGRIN; PEPTIDE; TECHNETIUM COMPLEX; TUMOR ANTIGEN;

EID: 84898008856     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400683q     Document Type: Article
Times cited : (40)

References (54)
  • 1
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes, R. O. Integrins: bidirectional, allosteric signaling machines Cell 2002, 110 (6) 673-687
    • (2002) Cell , vol.110 , Issue.6 , pp. 673-687
    • Hynes, R.O.1
  • 2
    • 0027773003 scopus 로고
    • Integrins as differential cell lineage markers of primary liver tumors
    • Volpes, R.; van den Oord, J. J.; Desmet, V. J. Integrins as differential cell lineage markers of primary liver tumors Am. J. Pathol. 1993, 142 (5) 1483-1492
    • (1993) Am. J. Pathol. , vol.142 , Issue.5 , pp. 1483-1492
    • Volpes, R.1    Van Den Oord, J.J.2    Desmet, V.J.3
  • 3
    • 0032721665 scopus 로고    scopus 로고
    • Role of integrins in cancer: Survey of expression patterns
    • Mizejewski, G. J. Role of integrins in cancer: survey of expression patterns Proc. Soc. Exp. Biol. Med. 1999, 222 (2) 124-138
    • (1999) Proc. Soc. Exp. Biol. Med. , vol.222 , Issue.2 , pp. 124-138
    • Mizejewski, G.J.1
  • 4
    • 0028941413 scopus 로고
    • Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing
    • Van Waes, C. Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing Head Neck 1995, 17 (2) 140-147
    • (1995) Head Neck , vol.17 , Issue.2 , pp. 140-147
    • Van Waes, C.1
  • 5
  • 6
    • 0026644051 scopus 로고
    • Integrins and their accessory adhesion molecules in mammary carcinomas: Loss of polarization in poorly differentiated tumors
    • Pignatelli, M.; Cardillo, M. R.; Hanby, A.; Stamp, G. W. Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors Hum. Pathol. 1992, 23 (10) 1159-1166
    • (1992) Hum. Pathol. , vol.23 , Issue.10 , pp. 1159-1166
    • Pignatelli, M.1    Cardillo, M.R.2    Hanby, A.3    Stamp, G.W.4
  • 7
    • 70249086983 scopus 로고    scopus 로고
    • Defining the role of integrin alphavbeta6 in cancer
    • Bandyopadhyay, A.; Raghavan, S. Defining the role of integrin alphavbeta6 in cancer Curr. Drug Targets 2009, 10 (7) 645-652
    • (2009) Curr. Drug Targets , vol.10 , Issue.7 , pp. 645-652
    • Bandyopadhyay, A.1    Raghavan, S.2
  • 8
    • 48549103201 scopus 로고    scopus 로고
    • Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factorbeta activation and retards biliary fibrosis progression
    • Patsenker, E.; Popov, Y.; Stickel, F.; Jonczyk, A.; Goodman, S. L.; Schuppan, D. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factorbeta activation and retards biliary fibrosis progression Gastroenterology 2008, 135 (2) 660-670
    • (2008) Gastroenterology , vol.135 , Issue.2 , pp. 660-670
    • Patsenker, E.1    Popov, Y.2    Stickel, F.3    Jonczyk, A.4    Goodman, S.L.5    Schuppan, D.6
  • 9
    • 39149111929 scopus 로고    scopus 로고
    • Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    • Popov, Y.; Patsenker, E.; Stickel, F.; Zaks, J.; Bhaskar, K. R.; Niedobitek, G.; Kolb, A.; Friess, H.; Schuppan, D. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies J. Hepatol. 2008, 48 (3) 453-464
    • (2008) J. Hepatol. , vol.48 , Issue.3 , pp. 453-464
    • Popov, Y.1    Patsenker, E.2    Stickel, F.3    Zaks, J.4    Bhaskar, K.R.5    Niedobitek, G.6    Kolb, A.7    Friess, H.8    Schuppan, D.9
  • 11
    • 0027234361 scopus 로고
    • Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues
    • Breuss, J. M.; Gillett, N.; Lu, L.; Sheppard, D.; Pytela, R. Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues J. Histochem. Cytochem. 1993, 41 (10) 1521-1527
    • (1993) J. Histochem. Cytochem. , vol.41 , Issue.10 , pp. 1521-1527
    • Breuss, J.M.1    Gillett, N.2    Lu, L.3    Sheppard, D.4    Pytela, R.5
  • 12
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • Lee, J. M.; Dedhar, S.; Kalluri, R.; Thompson, E. W. The epithelial-mesenchymal transition: new insights in signaling, development, and disease J. Cell Biol. 2006, 172 (7) 973-981
    • (2006) J. Cell Biol. , vol.172 , Issue.7 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 13
    • 4644324446 scopus 로고    scopus 로고
    • Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong upregulation in pancreatic ductal adenocarcinomas in vivo and in vitro
    • Sipos, B.; Hahn, D.; Carceller, A.; Piulats, J.; Hedderich, J.; Kalthoff, H.; Doodman, S. L.; Kosmahl, M.; Kloppel, G. Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong upregulation in pancreatic ductal adenocarcinomas in vivo and in vitro Histopathology 2004, 45 (3) 226-236
    • (2004) Histopathology , vol.45 , Issue.3 , pp. 226-236
    • Sipos, B.1    Hahn, D.2    Carceller, A.3    Piulats, J.4    Hedderich, J.5    Kalthoff, H.6    Doodman, S.L.7    Kosmahl, M.8    Kloppel, G.9
  • 14
    • 0035798107 scopus 로고    scopus 로고
    • Role of the alpha(v)beta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro
    • Xue, H.; Atakilit, A.; Zhu, W.; Li, X.; Ramos, D. M.; Pytela, R. Role of the alpha(v)beta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro Biochem. Biophys. Res. Commun. 2001, 288 (3) 610-618
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , Issue.3 , pp. 610-618
    • Xue, H.1    Atakilit, A.2    Zhu, W.3    Li, X.4    Ramos, D.M.5    Pytela, R.6
  • 15
    • 0036076481 scopus 로고    scopus 로고
    • Tenascin and beta 6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas
    • Regezi, J. A.; Ramos, D. M.; Pytela, R.; Dekker, N. P.; Jordan, R. C. Tenascin and beta 6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas Oral Oncol. 2002, 38 (4) 332-336
    • (2002) Oral Oncol. , vol.38 , Issue.4 , pp. 332-336
    • Regezi, J.A.1    Ramos, D.M.2    Pytela, R.3    Dekker, N.P.4    Jordan, R.C.5
  • 16
    • 0036799740 scopus 로고    scopus 로고
    • Alpha(v)beta(6) integrin-A marker for the malignant potential of epithelial ovarian cancer
    • Ahmed, N.; Riley, C.; Rice, G. E.; Quinn, M. A.; Baker, M. S. Alpha(v)beta(6) integrin-A marker for the malignant potential of epithelial ovarian cancer J. Histochem. Cytochem. 2002, 50 (10) 1371-1380
    • (2002) J. Histochem. Cytochem. , vol.50 , Issue.10 , pp. 1371-1380
    • Ahmed, N.1    Riley, C.2    Rice, G.E.3    Quinn, M.A.4    Baker, M.S.5
  • 17
    • 0036123185 scopus 로고    scopus 로고
    • Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade
    • Ahmed, N.; Pansino, F.; Clyde, R.; Murthi, P.; Quinn, M. A.; Rice, G. E.; Agrez, M. V.; Mok, S.; Baker, M. S. Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade Carcinogenesis 2002, 23 (2) 237-244
    • (2002) Carcinogenesis , vol.23 , Issue.2 , pp. 237-244
    • Ahmed, N.1    Pansino, F.2    Clyde, R.3    Murthi, P.4    Quinn, M.A.5    Rice, G.E.6    Agrez, M.V.7    Mok, S.8    Baker, M.S.9
  • 18
    • 0242668787 scopus 로고    scopus 로고
    • Expression of alphav integrin family in gastric carcinomas: Increased alphavbeta6 is associated with lymph node metastasis
    • Kawashima, A.; Tsugawa, S.; Boku, A.; Kobayashi, M.; Minamoto, T.; Nakanishi, I.; Oda, Y. Expression of alphav integrin family in gastric carcinomas: increased alphavbeta6 is associated with lymph node metastasis Pathol. Res. Pract. 2003, 199 (2) 57-64
    • (2003) Pathol. Res. Pract. , vol.199 , Issue.2 , pp. 57-64
    • Kawashima, A.1    Tsugawa, S.2    Boku, A.3    Kobayashi, M.4    Minamoto, T.5    Nakanishi, I.6    Oda, Y.7
  • 19
    • 34347359740 scopus 로고    scopus 로고
    • Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival
    • Hazelbag, S.; Kenter, G. G.; Gorter, A.; Dreef, E. J.; Koopman, L. A.; Violette, S. M.; Weinreb, P. H.; Fleuren, G. J. Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival J. Pathol. 2007, 212 (3) 316-324
    • (2007) J. Pathol. , vol.212 , Issue.3 , pp. 316-324
    • Hazelbag, S.1    Kenter, G.G.2    Gorter, A.3    Dreef, E.J.4    Koopman, L.A.5    Violette, S.M.6    Weinreb, P.H.7    Fleuren, G.J.8
  • 20
    • 14944348752 scopus 로고    scopus 로고
    • Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    • Bates, R. C.; Bellovin, D. I.; Brown, C.; Maynard, E.; Wu, B.; Kawakatsu, H.; Sheppard, D.; Oettgen, P.; Mercurio, A. M. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma J. Clin. Invest. 2005, 115 (2) 339-347
    • (2005) J. Clin. Invest. , vol.115 , Issue.2 , pp. 339-347
    • Bates, R.C.1    Bellovin, D.I.2    Brown, C.3    Maynard, E.4    Wu, B.5    Kawakatsu, H.6    Sheppard, D.7    Oettgen, P.8    Mercurio, A.M.9
  • 21
    • 34250862163 scopus 로고    scopus 로고
    • A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
    • Elayadi, A. N.; Samli, K. N.; Prudkin, L.; Liu, Y. H.; Bian, A.; Xie, X. J.; Wistuba, I. I.; Roth, J. A.; McGuire, M. J.; Brown, K. C. A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer Cancer Res. 2007, 67 (12) 5889-5895
    • (2007) Cancer Res. , vol.67 , Issue.12 , pp. 5889-5895
    • Elayadi, A.N.1    Samli, K.N.2    Prudkin, L.3    Liu, Y.H.4    Bian, A.5    Xie, X.J.6    Wistuba, I.I.7    Roth, J.A.8    McGuire, M.J.9    Brown, K.C.10
  • 25
  • 26
    • 74749088094 scopus 로고    scopus 로고
    • Cyclic alphavbeta6-targeting peptide selected from biopanning with clinical potential for head and neck squamous cell carcinoma
    • Hsiao, J. R.; Chang, Y.; Chen, Y. L.; Hsieh, S. H.; Hsu, K. F.; Wand, C. F.; Tsai, S. T.; Jin, Y. T. Cyclic alphavbeta6-targeting peptide selected from biopanning with clinical potential for head and neck squamous cell carcinoma Head Neck 2010, 32 (2) 160-172
    • (2010) Head Neck , vol.32 , Issue.2 , pp. 160-172
    • Hsiao, J.R.1    Chang, Y.2    Chen, Y.L.3    Hsieh, S.H.4    Hsu, K.F.5    Wand, C.F.6    Tsai, S.T.7    Jin, Y.T.8
  • 27
    • 67651006249 scopus 로고    scopus 로고
    • Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model
    • Hausner, S. H.; Abbey, C. K.; Bold, R. J.; Gagnon, M. K.; Marik, J.; Marshall, J. F.; Stanecki, C. E.; Sutcliffe, J. L. Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model Cancer Res. 2009, 69 (14) 5843-5850
    • (2009) Cancer Res. , vol.69 , Issue.14 , pp. 5843-5850
    • Hausner, S.H.1    Abbey, C.K.2    Bold, R.J.3    Gagnon, M.K.4    Marik, J.5    Marshall, J.F.6    Stanecki, C.E.7    Sutcliffe, J.L.8
  • 29
    • 84856513069 scopus 로고    scopus 로고
    • Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer
    • Kimura, R. H.; Teed, R.; Hackel, B. J.; Pysz, M. A.; Chuang, C. Z.; Sathirachinda, A.; Willmann, J. K.; Gambhir, S. S. Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer Clin. Cancer Res. 2012, 18 (3) 839-849
    • (2012) Clin. Cancer Res. , vol.18 , Issue.3 , pp. 839-849
    • Kimura, R.H.1    Teed, R.2    Hackel, B.J.3    Pysz, M.A.4    Chuang, C.Z.5    Sathirachinda, A.6    Willmann, J.K.7    Gambhir, S.S.8
  • 30
    • 0028090517 scopus 로고
    • A common structural motif incorporating a cystine knot and a triple-stranded β-sheet in toxic and inhibitory polypeptides
    • Pallaghy, P. K.; Nielsen, K. J.; Craik, D. J.; Norton, R. S. A common structural motif incorporating a cystine knot and a triple-stranded β-sheet in toxic and inhibitory polypeptides Protein Sci. 1994, 3 (10) 1833-1839
    • (1994) Protein Sci. , vol.3 , Issue.10 , pp. 1833-1839
    • Pallaghy, P.K.1    Nielsen, K.J.2    Craik, D.J.3    Norton, R.S.4
  • 31
    • 2442715239 scopus 로고    scopus 로고
    • Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: The importance of the cyclic cystine knot
    • Colgrave, M. L.; Craik, D. J. Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot Biochemistry 2004, 43 (20) 5965-5975
    • (2004) Biochemistry , vol.43 , Issue.20 , pp. 5965-5975
    • Colgrave, M.L.1    Craik, D.J.2
  • 33
    • 33745098362 scopus 로고    scopus 로고
    • The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery
    • Werle, M.; Schmitz, T.; Huang, H. L.; Wentzel, A.; Kolmar, H.; Bernkop-Schnurch, A. The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery J. Drug Target 2006, 14 (3) 137-146
    • (2006) J. Drug Target , vol.14 , Issue.3 , pp. 137-146
    • Werle, M.1    Schmitz, T.2    Huang, H.L.3    Wentzel, A.4    Kolmar, H.5    Bernkop-Schnurch, A.6
  • 34
    • 38749091363 scopus 로고    scopus 로고
    • KNOTTIN: The knottin or inhibitor cystine knot scaffold in 2007
    • Database Issue
    • Gracy, J.; Le-Nguyen, D.; Gelly, J. C.; Kaas, Q.; Heitz, A.; Chiche, L. KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007 Nucl. Acid Res. 2008, 36 (Database issue) D314-D319
    • (2008) Nucl. Acid Res. , vol.36
    • Gracy, J.1    Le-Nguyen, D.2    Gelly, J.C.3    Kaas, Q.4    Heitz, A.5    Chiche, L.6
  • 35
    • 70349664200 scopus 로고    scopus 로고
    • Interrogating and predicting tolerated sequence diversity in protein folds: Application to E. Elaterium trypsin inhibitor-II cystine-knot miniprotein
    • Lahti, J. L.; Silverman, A. P.; Cochran, J. R. Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein PLoS Comput. Biol. 2009, 5 (9) e1000499
    • (2009) PLoS Comput. Biol. , vol.5 , Issue.9 , pp. 1000499
    • Lahti, J.L.1    Silverman, A.P.2    Cochran, J.R.3
  • 36
    • 79958012153 scopus 로고    scopus 로고
    • Bioactive cystine knot proteins
    • Daly, N. L.; Craik, D. J. Bioactive cystine knot proteins Curr. Opin. Chem. Biol. 2011, 15 (3) 362-368
    • (2011) Curr. Opin. Chem. Biol. , vol.15 , Issue.3 , pp. 362-368
    • Daly, N.L.1    Craik, D.J.2
  • 37
    • 65549092007 scopus 로고    scopus 로고
    • Engineered knottin peptides: A new class of agents for imaging integrin expression in living subjects
    • Kimura, R. H.; Cheng, Z.; Gambhir, S. S.; Cochran, J. R. Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects Cancer Res. 2009, 69 (6) 2435-2442
    • (2009) Cancer Res. , vol.69 , Issue.6 , pp. 2435-2442
    • Kimura, R.H.1    Cheng, Z.2    Gambhir, S.S.3    Cochran, J.R.4
  • 38
    • 84855215798 scopus 로고    scopus 로고
    • Protein Scaffolds Based Molecular Probes for Cancer Molecular Imaging
    • Miao, Z.; Levi, J.; Cheng, Z. Protein Scaffolds Based Molecular Probes for Cancer Molecular Imaging Amino Acids 2011, 41 (5) 1037-1047
    • (2011) Amino Acids , vol.41 , Issue.5 , pp. 1037-1047
    • Miao, Z.1    Levi, J.2    Cheng, Z.3
  • 40
    • 4043130469 scopus 로고    scopus 로고
    • Direct reductive alkylation of amino acids: Synthesis of bifunctional chelates for nuclear imaging
    • Levadala, M. K.; Banerjee, S. R.; Maresca, K. P.; Babich, J. W.; Zubieta, J. Direct reductive alkylation of amino acids: synthesis of bifunctional chelates for nuclear imaging Synthesis 2004, 11, 1759-1766
    • (2004) Synthesis , vol.11 , pp. 1759-1766
    • Levadala, M.K.1    Banerjee, S.R.2    Maresca, K.P.3    Babich, J.W.4    Zubieta, J.5
  • 42
    • 70349462873 scopus 로고    scopus 로고
    • Engineered cystine knot peptides that bind avβ3, avβ5, and a5β1 integrins with low-nanomolar affinity
    • Kimura, R. H.; Levin, A. M.; Cochran, F. V.; Cochran, J. R. Engineered cystine knot peptides that bind avβ3, avβ5, and a5β1 integrins with low-nanomolar affinity Proteins 2009, 77 (2) 359-369
    • (2009) Proteins , vol.77 , Issue.2 , pp. 359-369
    • Kimura, R.H.1    Levin, A.M.2    Cochran, F.V.3    Cochran, J.R.4
  • 43
    • 79951996425 scopus 로고    scopus 로고
    • Functional mutation of multiple solvent-exposed loops of the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein
    • Kimura, R. H.; Jones, D. S.; Jiang, L.; Miao, Z.; Cheng, Z.; Cochran, J. R. Functional mutation of multiple solvent-exposed loops of the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein PLoS One 2011, 6 (2) e16112
    • (2011) PLoS One , vol.6 , Issue.2 , pp. 16112
    • Kimura, R.H.1    Jones, D.S.2    Jiang, L.3    Miao, Z.4    Cheng, Z.5    Cochran, J.R.6
  • 45
    • 84862069208 scopus 로고    scopus 로고
    • PET imaging of integrin positive tumors using 18F labeled knottin peptides
    • Liu, S.; Liu, H.; Ren, G.; Kimura, R. H.; Cochran, J. R.; Cheng, Z. PET imaging of integrin positive tumors using 18F labeled knottin peptides Theranostics 2011, 1, 403-412
    • (2011) Theranostics , vol.1 , pp. 403-412
    • Liu, S.1    Liu, H.2    Ren, G.3    Kimura, R.H.4    Cochran, J.R.5    Cheng, Z.6
  • 50
    • 77949847038 scopus 로고    scopus 로고
    • A dual-labeled knottin peptide for PET and near-infrared fluorescence imaging of integrin expression in living subjects
    • Kimura, R. H.; Miao, Z.; Cheng, Z.; Gambhir, S. S.; Cochran, J. R. A dual-labeled knottin peptide for PET and near-infrared fluorescence imaging of integrin expression in living subjects Bioconjugate Chem. 2010, 21 (3) 436-444
    • (2010) Bioconjugate Chem. , vol.21 , Issue.3 , pp. 436-444
    • Kimura, R.H.1    Miao, Z.2    Cheng, Z.3    Gambhir, S.S.4    Cochran, J.R.5
  • 51
    • 58849105986 scopus 로고    scopus 로고
    • Single amino acid chelates (SAAC): A strategy for the design of technetium and rhenium radiopharmaceuticals
    • Bartholomä, M.; Valliant, J.; Maresca, K. P.; Babich, J.; Zubieta, J. Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals Chem. Commun. 2009, 5, 493-512
    • (2009) Chem. Commun. , vol.5 , pp. 493-512
    • Bartholomä, M.1    Valliant, J.2    Maresca, K.P.3    Babich, J.4    Zubieta, J.5
  • 53
    • 77953643007 scopus 로고    scopus 로고
    • Novel polar single amino acid chelates for technetium-99m tricarbonyl-based radiopharmaceuticals with enhanced renal clearance: Application to octreotide
    • Maresca, K. P.; Marquis, J. C.; Hillier, S. M.; Lu, G.; Femia, F. J.; Zimmerman, C. N.; Eckelman, W. C.; Joyal, J. L.; Babich, J. W. Novel polar single amino acid chelates for technetium-99m tricarbonyl-based radiopharmaceuticals with enhanced renal clearance: application to octreotide Bioconjugate Chem. 2010, 21 (6) 1032-1042
    • (2010) Bioconjugate Chem. , vol.21 , Issue.6 , pp. 1032-1042
    • Maresca, K.P.1    Marquis, J.C.2    Hillier, S.M.3    Lu, G.4    Femia, F.J.5    Zimmerman, C.N.6    Eckelman, W.C.7    Joyal, J.L.8    Babich, J.W.9


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