메뉴 건너뛰기




Volumn 13, Issue 6, 2014, Pages 1041-1048

The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target

Author keywords

Apoptosis; NMNAT 2; p53

Indexed keywords

DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE 2; NUTLIN 3; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84897997735     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.28128     Document Type: Article
Times cited : (32)

References (60)
  • 1
    • 84889034239 scopus 로고    scopus 로고
    • NAD metabolism and functions: A common therapeutic target for neoplastic, metabolic and neurodegenerative diseases
    • PMID:24171774
    • Di Stefano G, Manerba M, Vettraino M. NAD metabolism and functions: a common therapeutic target for neoplastic, metabolic and neurodegenerative diseases. Curr Top Med Chem 2013; 13:2918-29; PMID:24171774
    • (2013) Curr Top Med Chem , vol.13 , pp. 2918-2929
    • Di Stefano, G.1    Manerba, M.2    Vettraino, M.3
  • 2
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • PMID:10693811
    • Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800; PMID:10693811; http://dx.doi.org/10.1038/35001622
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 3
    • 55749084738 scopus 로고    scopus 로고
    • A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    • PMID:18794531
    • Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci USA 2008; 105:14447-52; PMID:18794531; http://dx.doi.org/10.1073/pnas.0803790105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14447-14452
    • Ahn, B.H.1    Kim, H.S.2    Song, S.3    Lee, I.H.4    Liu, J.5    Vassilopoulos, A.6    Deng, C.X.7    Finkel, T.8
  • 7
    • 0030984490 scopus 로고    scopus 로고
    • PARP is important for genomic stability but dispensable in apoptosis
    • PMID:9308963
    • Wang ZQ, Stingl L, Morrison C, Jantsch M, Los M, Schulze-Osthoff K, Wagner EF. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev 1997; 11:2347-58; PMID:9308963; http://dx.doi.org/10.1101/gad.11.18. 2347
    • (1997) Genes Dev , vol.11 , pp. 2347-2358
    • Wang, Z.Q.1    Stingl, L.2    Morrison, C.3    Jantsch, M.4    Los, M.5    Schulze-Osthoff, K.6    Wagner, E.F.7
  • 9
    • 0027892021 scopus 로고
    • Synthesis and degradation of cyclic ADP-ribose by NAD glycohydrolases
    • PMID:8395705
    • Kim H, Jacobson EL, Jacobson MK. Synthesis and degradation of cyclic ADP-ribose by NAD glycohydrolases. Science 1993; 261:1330-3; PMID:8395705; http://dx.doi.org/10.1126/science.8395705
    • (1993) Science , vol.261 , pp. 1330-1333
    • Kim, H.1    Jacobson, E.L.2    Jacobson, M.K.3
  • 11
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • PMID:13351639
    • Warburg O. On respiratory impairment in cancer cells. Science 1956; 124:269-70; PMID:13351639
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 12
    • 77951445047 scopus 로고    scopus 로고
    • Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies
    • PMID:20406068
    • Heikal AA. Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies. Biomark Med 2010; 4:241-63; PMID:20406068; http://dx.doi.org/10.2217/bmm.10.1
    • (2010) Biomark Med , vol.4 , pp. 241-263
    • Heikal, A.A.1
  • 13
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • PMID:18177721
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7:11-20; PMID:18177721; http://dx.doi.org/10.1016/j.cmet.2007.10.002
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 14
    • 42449114966 scopus 로고    scopus 로고
    • Transcriptional control of human p53-regulated genes
    • PMID:18431400
    • Riley T, Sontag E, Chen P, Levine A. Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 2008; 9:402-12; PMID:18431400; http://dx.doi.org/10.1038/nrm2395
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 402-412
    • Riley, T.1    Sontag, E.2    Chen, P.3    Levine, A.4
  • 15
    • 77955345508 scopus 로고    scopus 로고
    • p53 at a glance
    • PMID:20940128
    • Brady CA, Attardi LD. p53 at a glance. J Cell Sci 2010; 123:2527-32; PMID:20940128; http://dx.doi.org/10.1242/jcs.064501
    • (2010) J Cell Sci , vol.123 , pp. 2527-2532
    • Brady, C.A.1    Attardi, L.D.2
  • 16
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the Light: The Growing Complexity of p53
    • PMID:19410540
    • Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009; 137:413-31; PMID:19410540; http://dx.doi.org/10.1016/j.cell. 2009.04.037
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 17
    • 70349438905 scopus 로고    scopus 로고
    • The expanding universe of p53 targets
    • PMID:19776742
    • Menendez D, Inga A, Resnick MA. The expanding universe of p53 targets. Nat Rev Cancer 2009; 9:724-37; PMID:19776742; http://dx.doi.org/10.1038/nrc2730
    • (2009) Nat Rev Cancer , vol.9 , pp. 724-737
    • Menendez, D.1    Inga, A.2    Resnick, M.A.3
  • 18
    • 84887430076 scopus 로고    scopus 로고
    • Metabolic regulation by p53 family members
    • PMID:23954639
    • Berkers CR, Maddocks OD, Cheung EC, Mor I, Vousden KH. Metabolic regulation by p53 family members. Cell Metab 2013; 18:617-33; PMID:23954639; http://dx.doi.org/10.1016/j.cmet.2013.06.019
    • (2013) Cell Metab , vol.18 , pp. 617-633
    • Berkers, C.R.1    Maddocks, O.D.2    Cheung, E.C.3    Mor, I.4    Vousden, K.H.5
  • 19
    • 79961204091 scopus 로고    scopus 로고
    • p53, aerobic metabolism, and cancer
    • PMID:20919942
    • Lago CU, Sung HJ, Ma W, Wang PY, Hwang PM. p53, aerobic metabolism, and cancer. Antioxid Redox Signal 2011; 15:1739-48; PMID:20919942; http://dx.doi.org/10.1089/ars.2010.3650
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1739-1748
    • Lago, C.U.1    Sung, H.J.2    Ma, W.3    Wang, P.Y.4    Hwang, P.M.5
  • 20
    • 0030882879 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
    • PMID:9278438
    • Mathupala SP, Heese C, Pedersen PL. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem 1997; 272:22776-80; PMID:9278438; http://dx.doi.org/10.1074/jbc.272.36.22776
    • (1997) J Biol Chem , vol.272 , pp. 22776-22780
    • Mathupala, S.P.1    Heese, C.2    Pedersen, P.L.3
  • 21
    • 77951209414 scopus 로고    scopus 로고
    • The role of p53 in glucose metabolism
    • PMID:20061129
    • Cheung EC, Vousden KH. The role of p53 in glucose metabolism. Curr Opin Cell Biol 2010; 22:186-91; PMID:20061129; http://dx.doi.org/10.1016/j.ceb.2009. 12.006
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 186-191
    • Cheung, E.C.1    Vousden, K.H.2
  • 22
    • 70349459599 scopus 로고    scopus 로고
    • p53 and metabolism
    • PMID:19759539
    • Vousden KH, Ryan KM. p53 and metabolism. Nat Rev Cancer 2009; 9:691-700; PMID:19759539; http://dx.doi.org/10.1038/nrc2715
    • (2009) Nat Rev Cancer , vol.9 , pp. 691-700
    • Vousden, K.H.1    Ryan, K.M.2
  • 23
    • 1442330508 scopus 로고    scopus 로고
    • Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo
    • PMID:14982997
    • Luo J, Li M, Tang Y, Laszkowska M, Roeder RG, Gu W. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci USA 2004; 101:2259-64; PMID:14982997; http://dx.doi.org/10.1073/pnas. 0308762101
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2259-2264
    • Luo, J.1    Li, M.2    Tang, Y.3    Laszkowska, M.4    Roeder, R.G.5    Gu, W.6
  • 25
    • 84870809563 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1
    • PMID:22286760
    • Lee MH, Na H, Kim EJ, Lee HW, Lee MO. Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1. Oncogene 2012; 31:5099-107; PMID:22286760; http://dx.doi.org/10.1038/onc.2012.2
    • (2012) Oncogene , vol.31 , pp. 5099-5107
    • Lee, M.H.1    Na, H.2    Kim, E.J.3    Lee, H.W.4    Lee, M.O.5
  • 27
    • 40849119972 scopus 로고    scopus 로고
    • NAD+ and vitamin B3: From metabolism to therapies
    • PMID:18165311
    • Sauve AA. NAD+ and vitamin B3: from metabolism to therapies. J Pharmacol Exp Ther 2008; 324:883-93; PMID:18165311; http://dx.doi.org/10.1124/jpet.107. 120758
    • (2008) J Pharmacol Exp Ther , vol.324 , pp. 883-893
    • Sauve, A.A.1
  • 28
    • 27744501798 scopus 로고    scopus 로고
    • Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms
    • PMID:16118205
    • Berger F, Lau C, Dahlmann M, Ziegler M. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J Biol Chem 2005; 280:36334-41; PMID:16118205; http://dx.doi.org/10.1074/jbc.M508660200
    • (2005) J Biol Chem , vol.280 , pp. 36334-36341
    • Berger, F.1    Lau, C.2    Dahlmann, M.3    Ziegler, M.4
  • 29
    • 65549118773 scopus 로고    scopus 로고
    • Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
    • PMID:19286518
    • Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 2009; 324:654-7; PMID:19286518; http://dx.doi.org/10.1126/science.1170803
    • (2009) Science , vol.324 , pp. 654-657
    • Nakahata, Y.1    Sahar, S.2    Astarita, G.3    Kaluzova, M.4    Sassone-Corsi, P.5
  • 33
    • 0037173059 scopus 로고    scopus 로고
    • The p53MH algorithm and its application in detecting p53-responsive genes
    • PMID:12077306
    • Hoh J, Jin S, Parrado T, Edington J, Levine AJ, Ott J. The p53MH algorithm and its application in detecting p53-responsive genes. Proc Natl Acad Sci USA 2002; 99:8467-72; PMID:12077306; http://dx.doi.org/10.1073/pnas. 132268899
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8467-8472
    • Hoh, J.1    Jin, S.2    Parrado, T.3    Edington, J.4    Levine, A.J.5    Ott, J.6
  • 35
    • 85047697335 scopus 로고    scopus 로고
    • A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes
    • PMID:11850816
    • Thornborrow EC, Patel S, Mastropietro AE, Schwartzfarb EM, Manfredi JJ. A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes. Oncogene 2002; 21:990-9; PMID:11850816; http://dx.doi.org/10.1038/sj.onc.1205069
    • (2002) Oncogene , vol.21 , pp. 990-999
    • Thornborrow, E.C.1    Patel, S.2    Mastropietro, A.E.3    Schwartzfarb, E.M.4    Manfredi, J.J.5
  • 36
    • 0029131447 scopus 로고
    • A functional p53-responsive intronic promoter is contained within the human mdm2 gene
    • PMID:7651818
    • Zauberman A, Flusberg D, Haupt Y, Barak Y, Oren M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res 1995; 23:2584-92; PMID:7651818; http://dx.doi.org/10.1093/nar/ 23.14.2584
    • (1995) Nucleic Acids Res , vol.23 , pp. 2584-2592
    • Zauberman, A.1    Flusberg, D.2    Haupt, Y.3    Barak, Y.4    Oren, M.5
  • 37
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • PMID:22549953
    • Dang CV. Links between metabolism and cancer. Genes Dev 2012; 26:877-90; PMID:22549953; http://dx.doi.org/10.1101/gad.189365.112
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 38
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • PMID:21258394
    • Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11:85-95; PMID:21258394; http://dx.doi.org/10.1038/nrc2981
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 39
    • 22144499162 scopus 로고    scopus 로고
    • Ageing and metabolism: Drug discovery opportunities
    • PMID:15976816
    • Curtis R, Geesaman BJ, DiStefano PS. Ageing and metabolism: drug discovery opportunities. Nat Rev Drug Discov 2005; 4:569-80; PMID:15976816; http://dx.doi.org/10.1038/nrd1777
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 569-580
    • Curtis, R.1    Geesaman, B.J.2    DiStefano, P.S.3
  • 40
    • 33745867638 scopus 로고    scopus 로고
    • Poly(ADP-ribose): Novel functions for an old molecule
    • PMID:16829982
    • Schreiber V, Dantzer F, Ame JC, de Murcia G. Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol 2006; 7:517-28; PMID:16829982; http://dx.doi.org/10.1038/nrm1963
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 517-528
    • Schreiber, V.1    Dantzer, F.2    Ame, J.C.3    De Murcia, G.4
  • 41
    • 84891860991 scopus 로고    scopus 로고
    • The Many Faces of Sirtuins: Coupling of NAD metabolism, sirtuins and lifespan
    • PMID:24398962
    • Verdin E. The Many Faces of Sirtuins: Coupling of NAD metabolism, sirtuins and lifespan. Nat Med 2014; 20:25-7; PMID:24398962; http://dx.doi.org/10.1038/nm.3447
    • (2014) Nat Med , vol.20 , pp. 25-27
    • Verdin, E.1
  • 42
    • 84873055344 scopus 로고    scopus 로고
    • MDM2, MDMX and p53 in oncogenesis and cancer therapy
    • PMID:23303139
    • Wade M, Li YC, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 2013; 13:83-96; PMID:23303139; http://dx.doi.org/10. 1038/nrc3430
    • (2013) Nat Rev Cancer , vol.13 , pp. 83-96
    • Wade, M.1    Li, Y.C.2    Wahl, G.M.3
  • 43
    • 84878717391 scopus 로고    scopus 로고
    • Sirtuin deacetylases in neurodegenerative diseases of aging
    • PMID:23689277
    • Herskovits AZ, Guarente L. Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res 2013; 23:746-58; PMID:23689277; http://dx.doi.org/ 10.1038/cr.2013.70
    • (2013) Cell Res , vol.23 , pp. 746-758
    • Herskovits, A.Z.1    Guarente, L.2
  • 44
    • 84886794616 scopus 로고    scopus 로고
    • Senescence and aging: The critical roles of p53
    • PMID:23416979
    • Rufini A, Tucci P, Celardo I, Melino G. Senescence and aging: the critical roles of p53. Oncogene 2013; 32:5129-43; PMID:23416979; http://dx.doi.org/10.1038/onc.2012.640
    • (2013) Oncogene , vol.32 , pp. 5129-5143
    • Rufini, A.1    Tucci, P.2    Celardo, I.3    Melino, G.4
  • 45
    • 33746228121 scopus 로고    scopus 로고
    • Sirtuins in aging and age-related disease
    • PMID:16873059
    • Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell 2006; 126:257-68; PMID:16873059; http://dx.doi.org/10.1016/j.cell.2006.07.002
    • (2006) Cell , vol.126 , pp. 257-268
    • Longo, V.D.1    Kennedy, B.K.2
  • 47
    • 84925297402 scopus 로고    scopus 로고
    • p53 suppresses carcinoma progression by inhibiting mTOR pathway activation
    • PMID:24469052
    • Akeno N, Miller AL, Ma X, Wikenheiser-Brokamp KA. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene 2014; PMID:24469052; http://dx.doi.org/10.1038/onc.2013.589
    • (2014) Oncogene
    • Akeno, N.1    Miller, A.L.2    Ma, X.3    Wikenheiser-Brokamp, K.A.4
  • 48
    • 48449101433 scopus 로고    scopus 로고
    • p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • PMID:18692468
    • Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008; 134:451-60; PMID:18692468; http://dx.doi.org/10.1016/j.cell.2008.06.028
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 49
    • 78349246236 scopus 로고    scopus 로고
    • Shifting senescence into quiescence by turning up p53
    • PMID:20980826
    • Serrano M. Shifting senescence into quiescence by turning up p53. Cell Cycle 2010; 9:4256-7; PMID:20980826; http://dx.doi.org/10.4161/cc.9.21.13785
    • (2010) Cell Cycle , vol.9 , pp. 4256-4257
    • Serrano, M.1
  • 50
    • 78349286289 scopus 로고    scopus 로고
    • Weak p53 permits senescence during cell cycle arrest
    • PMID:21051933
    • Leontieva OV, Gudkov AV, Blagosklonny MV. Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010; 9:4323-7; PMID:21051933; http://dx.doi.org/10.4161/cc.9.21.13584
    • (2010) Cell Cycle , vol.9 , pp. 4323-4327
    • Leontieva, O.V.1    Gudkov, A.V.2    Blagosklonny, M.V.3
  • 52
    • 77954617977 scopus 로고    scopus 로고
    • Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons
    • PMID:20126265
    • Gilley J, Coleman MP. Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons. PLoS Biol 2010; 8:e1000300; PMID:20126265; http://dx.doi.org/10.1371/journal.pbio.1000300
    • (2010) PLoS Biol , vol.8
    • Gilley, J.1    Coleman, M.P.2
  • 54
    • 73449100102 scopus 로고    scopus 로고
    • Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity
    • PMID:19778564
    • Yan T, Feng Y, Zheng J, Ge X, Zhang Y, Wu D, Zhao J, Zhai Q. Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int 2010; 56:101-6; PMID:19778564; http://dx.doi.org/10.1016/j.neuint.2009.09.007
    • (2010) Neurochem Int , vol.56 , pp. 101-106
    • Yan, T.1    Feng, Y.2    Zheng, J.3    Ge, X.4    Zhang, Y.5    Wu, D.6    Zhao, J.7    Zhai, Q.8
  • 55
    • 41549136422 scopus 로고    scopus 로고
    • Paths of convergence: Sirtuins in aging and neurodegeneration
    • PMID:18400158
    • Gan L, Mucke L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron 2008; 58:10-4; PMID:18400158; http://dx.doi.org/10. 1016/j.neuron.2008.03.015
    • (2008) Neuron , vol.58 , pp. 10-14
    • Gan, L.1    Mucke, L.2
  • 56
    • 84855368532 scopus 로고    scopus 로고
    • NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy
    • PMID:21965302
    • Ali YO, Ruan K, Zhai RG. NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum Mol Genet 2012; 21:237-50; PMID:21965302; http://dx.doi.org/10.1093/hmg/ddr449
    • (2012) Hum Mol Genet , vol.21 , pp. 237-250
    • Ali, Y.O.1    Ruan, K.2    Zhai, R.G.3
  • 58
    • 84855389519 scopus 로고    scopus 로고
    • CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy
    • PMID:22027994
    • Ljungberg MC, Ali YO, Zhu J, Wu CS, Oka K, Zhai RG, Lu HC. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet 2012; 21:251-67; PMID:22027994; http://dx.doi.org/10.1093/hmg/ ddr492
    • (2012) Hum Mol Genet , vol.21 , pp. 251-267
    • Ljungberg, M.C.1    Ali, Y.O.2    Zhu, J.3    Wu, C.S.4    Oka, K.5    Zhai, R.G.6    Lu, H.C.7
  • 59
    • 33846908937 scopus 로고    scopus 로고
    • p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled
    • PMID:17158927
    • Mattia M, Gottifredi V, McKinney K, Prives C. p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled. Mol Cell Biol 2007; 27:1309-20; PMID:17158927; http://dx.doi.org/10.1128/MCB.01520-06
    • (2007) Mol Cell Biol , vol.27 , pp. 1309-1320
    • Mattia, M.1    Gottifredi, V.2    McKinney, K.3    Prives, C.4
  • 60
    • 0037039319 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
    • PMID:11756653
    • Kaeser MD, Iggo RD. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc Natl Acad Sci USA 2002; 99:95-100; PMID:11756653; http://dx.doi.org/10. 1073/pnas.012283399
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 95-100
    • Kaeser, M.D.1    Iggo, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.