Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 8, 2014, Pages 2409-2415

  Wang, She Feng ^a   Yin, Yong ^a   Qiao, Fang ^a   Wu, Xun ^a   Sha, Shao ^a   Zhang, Li ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antibacterial activities; Metronidazole derivatives; Molecular docking; S. aureus TyrRS

Indexed keywords

1 (2 CHLOROPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (2 FLUOROPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZO 1 YL)ETHYL]PIPERAZINE; 1 (2 METHOXYPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (2,3 DICHLOROPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (2,4 DIMETHYLPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (3 CHLOROPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (3 METHOXYPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (3,4 DICHLOROPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (4 FLUOROPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 (4 METHOXYPHENYL) 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 BENZHYDRYL 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 [(4 CHLOROPHENYL)(PHENYL)METHYL] 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; 1 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL] 4 PHENYL PIPERAZINE; 1 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL] 4 [3 (TRIFLUOROMETHYL)PHENYL]PIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYL]PIPERAZINE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CHLORAMPHENICOL; METRONIDAZOLE; PENICILLIN G; PIPERAZINE DERIVATIVE; TYROSINE TRANSFER RNA LIGASE; UNCLASSIFIED DRUG; PIPERAZINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME BINDING; ESCHERICHIA COLI; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANALOGS AND DERIVATIVES; BINDING SITE; CHEMISTRY; DRUG EFFECTS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

BACILLUS SUBTILIS; ESCHERICHIA COLI; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PIPERAZINES; TYROSINE-TRNA LIGASE;

EID: 84897995018     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.03.004     Document Type: Article

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