Metronidazole-deoxybenzoin derivatives as anti-Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8

ChemMedChem

Volumn 5, Issue 7, 2010, Pages 1110-1116

  Luo, Yin ^a   Li, Huan Qiu ^a   Zhou, Yang ^a   Li, Zi Lin ^a   Yan, Tao ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Deoxybenzoins; Helicobacter pylori; HPE induced IL 8; Metronidazole

Indexed keywords

1 [2,3 DIHYDROXY 4 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHOXY]PHENYL] 2 (4 NITROPHENYL)ETHANONE; AMOXICILLIN; ANTIINFECTIVE AGENT; BENZOIN; INTERLEUKIN 8; KANAMYCIN; METRONIDAZOLE; UNCLASSIFIED DRUG; 1-(2,3-DIHYDROXY-4-(2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHOXY)PHENYL)-2-(4-NITROPHENYL)ETHANONE; DEOXYBENZOIN; IMIDAZOLE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; STOMACH MUCOSA; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BENZOIN; GASTRIC MUCOSA; HELICOBACTER PYLORI; IMIDAZOLES; INTERLEUKIN-8; METRONIDAZOLE;

EID: 77954140252     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000126     Document Type: Article

References (23)

1. Y. Katsura, S. Nishino, M. Ohno, K. Sakane, Y. Matsumoto, C. Morinaga, H. Ishikawa, H. Takasugi, J. Med. Chem. 1999, 42, 2920-2926.
2. G. Rubinstein, K. Dunkin, A. J. J. Howard, J. Antimicrob. Chemother. 1994, 34, 409-413.
3. H. Q. Li, C. Xu, H. S. Li, Z. P. Xiao, L. Shi, H. L. Zhu, ChemMedChem 2007, 2, 1361-1369.
4. S. Z. Ding, C. H. Cho, S. K. Lam, Biochem. Biophys. Res. Commun. 1997, 240, 561-565.
5. H. Shunji, S. Toshiro, Y. Kenji, I. Hiroshi, I. Emiko, S. Hirofumi, O. Keiji, A. Masahiro, H. Yoshikazu, Microbiol. Immunol. 2000, 44, 557-562.
6. P. P. Massion, A. Lindén, H. Inoue, M. Mathy, K. M. Grattan, J. A. Nadel, Am. J. Physiol. 1996, 271, L838-L843.
7. I. A. Ghouleha, A. Triantafillopoulosa, S. Magdera, Cytokine 2008, 43, 285-289.
8. A. Brauner, M. Soderhall, S. H. Jacobson, J. Lundahl, U. Andersson, J. Andersson, Clin. Exp. Immunol. 2001, 124, 423-428.
9. D. L. Butler, C. J. Jakielaszek, L. A. Miller, J. A. Poupard, Antimicrob. Agents Chemother. 1999, 43, 283-286.
10. K. M. Lammers, U. Helwig, E. Swennen, F. Rizzello, A. Venturi, E. Caramelli, M. A. Kamm, P. Brigidi, P. Gionchetti, M. Campieri, Am. J. Gastroenter. 2002, 97, 1182-1186.
11. M. B. Mallia, A. Mathur, S. Subramanian, S. Banerjee, H. D. Sarma, M. Venkatesh, Bioorg. Med. Chem. Lett. 2005, 15, 3398-3401.
12. S. F. Wang, Q. Jiang, Y. H. Ye, Y. Li, R. X. Tan, Bioorg. Med. Chem. 2005, 13, 4880-4890.
13. T. Shimoyama, S. Fukuda, Q. Liu, S. Nakaji, A. Munakata, K. Sugawara, Scand. J. Gastroenterol. 2001, 36, 153-157.
14. B. Han, H. Kim, K. Rhee, H. Han, M. Chung, Pharmacol. Res. 1995, 32, 201-207.
15. M. Aihara, D. Tsuchimoto, H. Takizawa, A. Azuma, H. Wakebe, Y. Ohmoto, K. Imagawa, M. Kikuchi, N. Mukaida, K. Matsushima, Infect. Immun. 1997, 65, 3218-3224.
16. K. Kassai, T. Yoshikawa, N. Yoshida, A. Hashiramoto, M. Kondo, H. Murase, Dig. Dis. Sci. 1999, 44, 237-242.
17. Y. Yamaoka, D. H. Kwon, D. Y. A. Graham, Proc. Natl. Acad. Sci. USA 2000, 97, 7533-7538.
18. P. Traxler, G. Bold, J. Frei, J. Med. Chem. 1997, 40, 3601-3616.
19. S. A. Sharma, M. K. Tummuru, M. J. Blaser, L. D. Kerr, J. Immunol. 1998, 160, 2401-2407.
20. S. Maeda, H. Yoshida, K. Ogura, Y. Mitsuno, Y. Hirata, Y. Yamaji, M. Akanuma, Y. Shiratori, M. Omata, Gastroenterology 2000, 119, 97-108.
21. H. Q. Li, Y. Luo, P. C. Lv, C. H. Liu, H. L. Zhu, Bioorg. Med. Chem. Lett. 2010, 20, 2025-2028.
22. Y. Katsura, T. Tomishi, Y. Inoue, K. Sakane, Y. Matsumoto, C. Morinaga, H. Ishikawa, H. Takasugi, J. Med. Chem. 2000, 43, 3315-3321.
23. M. Vasudevan, K. K. Gunnam, M. Parle, J. Ethnopharmacol. 2007, 109, 264-270.