Synthesis, Structure and Antibacterial Activity of Potent DNA Gyrase Inhibitors: N′-Benzoyl-3-(4-Bromophenyl)-1H-Pyrazole-5-Carbohydrazide Derivatives

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Sun, Juan ^a   Lv, Peng Cheng ^a   Yin, Yong ^a   Yuan, Rong Ju ^b   Ma, Jian ^b   Zhu, Hai Liang ^a,b  

^a NANJING UNIVERSITY   (China)

^b SHANDONG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 BROMOPHENYL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETHYL 4 (4 BROMOPHENYL) 2,4 DIOXOBUTANOATE; GYRASE INHIBITOR; N9 BENZOYL 3 (4 BROMOPHENYL) 1H PYRAZOLE 5 CARBOHYDRAZIDE DERIVATIVE; NOVOBIOCIN; PENICILLIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS AERUGINOSA; SIMULATION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; HYDRAZINES; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84880805844     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069751     Document Type: Article

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