Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1.1

Biochemical Pharmacology

Volumn 89, Issue 1, 2014, Pages 131-140

  Indurthi, Dinesh C ^a   Pera, Elena ^a   Kim, Hye Lim ^a   Chu, Cindy ^a   McLeod, Malcolm D ^b   Michael McIntosh, J ^c,d   Absalom, Nathan L ^a   Chebib, Mary ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha9alpha10; Nicotinic acetylcholine receptors; RgIA; Subunit stoichiometry; Vc1.1; Conotoxins

Indexed keywords

ALPHA CONOTOXIN VC1.1; ATROPINE; CALCIUM ION; CYSTEINE LOOP LIGAND GATED ION CHANNEL RECEPTOR; MESSENGER RNA; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA10; NICOTINIC RECEPTOR ALPHA9; NICOTINIC RECEPTOR ALPHA9ALPHA10; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; DRUG BINDING SITE; DRUG RECEPTOR BINDING; FEMALE; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS;

ALPHA9ALPHA10; NICOTINIC ACETYLCHOLINE RECEPTORS; RGIA; SUBUNIT STOICHIOMETRY; VC1.1; Α-CONOTOXINS;

ADULT; ANIMALS; BINDING SITES; CONOTOXINS; FEMALE; HUMANS; MICROELECTRODES; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 84897994261     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.02.002     Document Type: Article

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