Potential lipophilic nucleotide prodrugs: Synthesis, hydrolysis, and antiretroviral activity of AZT and d4T acyl nucleotides

Journal of Organic Chemistry

Volumn 61, Issue 3, 1996, Pages 895-902

  Bonnaffé, David ^a,b   Dupraz, Bernadette ^a   Ughetto Monfrin, Joël ^a   Namane, Abdelkader ^a   Henin, Yvette ^a   Dinh, Tam Huynh ^a  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE DERIVATIVE; PRODRUG; RNA DIRECTED DNA POLYMERASE; STAVUDINE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROLYSIS; LIPOPHILICITY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE;

EID: 0030049336     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo951354p     Document Type: Article

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