Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical Mucus

Molecular Pharmaceutics

Volumn 6, Issue 1, 2009, Pages 173-181

  Cu, Yen ^a   Saltzman, W Mark ^a  

^a Yale University   (United States)

Author keywords

Diffusion model; Drug delivery; Mucin; Mucosal transport; Polymer nanoparticles; Stealth; Surface modification

Indexed keywords

DRUG CARRIER; MACROGOL; NANOPARTICLE; POLYGLACTIN; LACTIC ACID; MACROGOL DERIVATIVE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; WATER;

ARTICLE; DIFFUSION; DIFFUSION COEFFICIENT; DISPERSION; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; FLUORESCENCE MICROSCOPY; HUMAN; MOLECULAR WEIGHT; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE PROPERTY; UTERINE CERVIX MUCUS; CHEMISTRY; METABOLISM; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE;

CERVIX MUCUS; DIFFUSION; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; SURFACE PROPERTIES; WATER;

EID: 62649100814     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp8001254     Document Type: Article

References (27)

1. Bansil, R.; Turner, B. S. Mucin structure, aggregation, physiological functions and biomedical applications. Curr. Opin. Colloid Interface Sci. 2006, 11, 164-170.
2. Thornton, D. J.; Sheehan, J. K. From mucins to mucus: toward a more coherent understanding of this essential barrier. Proc. Am. Thorac. Soc. 2004, 1, 54-61.
3. Lafitte, G.; Thuresson, K.; Soderman, O. Mixtures of mucin and oppositely charged surfactant aggregates with varying charge density. Phase behavior, association, and dynamics. Langmuir 2005, 21, 7097-104.
4. Albanese, C. T.; Cardona, M.; Smith, S. D.; Watkins, S.; Kurkchubasche, A. G.; Ulman, I.; Simmons, R. L.; Rowe, M. I. Role of intestinal mucus in transepithelial passage of bacteria across the intact ileum in vitro. Surgery 1994, 116, 76-82.
5. Kitson, C.; Angel, B.; Judd, D.; Rothery, S.; Severs, N. J.; Dewar, A.; Huang, L.; Wadsworth, S. C.; Cheng, S. H.; Geddes, D. M.; Alton, E. W. The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium. Gene Ther. 1999, 6, 534-46.
6. Yonemitsu, Y.; Kitson, C.; Ferrari, S.; Farley, R.; Griesenbach, U.; Judd, D.; Steel, R.; Scheid, P.; Zhu, J.; Jeffery, P. K.; Kato, A.; Hasan, M. K.; Nagai, Y.; Masaki, I.; Fukumura, M.; Hasegawa, M.; Geddes, D. M.; Alton, E. W. Efficient gene transfer to airway epithelium using recombinant Sendai virus. Nat. Biotechnol. 2000, 18, 970-3.
7. Olmsted, S. S.; Padgett, J. L.; Yudin, A. I.; Whaley, K. J.; Moench, T. R.; Cone, R. A. Diffusion of macromolecules and virus-like particles in human cervical mucus. Biophys. J. 2001, 81, 1930-7.
8. Lai, S. K.; O'Hanlon, D. E.; Harrold, S.; Man, S. T.; Wang, Y. Y.; Cone, R.; Hanes, J. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 1482-7.
9. Mundargi, R. C.; Babu, V. R.; Rangaswamy, V.; Patel, P.; Aminabhavi, T. M. Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J. Controlled Release 2008, 125, 193-209.
10. Panyam, J.; Labhasetwar, V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Delivery Rev. 2003, 55, 329-47.
11. Perez, C.; Sanchez, A.; Putnam, D.; Ting, D.; Langer, R.; Alonso, M. J. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J. Controlled Release 2001, 75, 211-24.
12. Tobio, M.; Sanchez, A.; Vila, A.; Soriano, I. I.; Evora, C.; Vila-Jato, J. L.; Alonso, M. J. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf. B Biointerfaces 2000, 18, 315-323.
13. Vila, A.; Gill, H.; McCallion, O.; Alonso, M. J. Transport of PLA- PEG particles across the nasal mucosa: effect of particle size and PEG coating density. J. Controlled Release 2004, 98, 231-44.
14. Stolnik, S.; Dunn, S. E.; Garnett, M. C.; Davies, M. C.; Coombes, A. G.; Taylor, D. C.; Irving, M. P.; Purkiss, S. C.; Tadros, T. F.; Davis, S. S.; et al. Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers. Pharm. Res. 1994, 11, 1800-8.
15. Esmaeili, F.; Ghahremani, M. H.; Esmaeili, B.; Khoshayand, M. R.; Atyabi, F.; Dinarvand, R. PLGA nanoparticles ofdifferent surface properties: preparation and evaluation of their body distribution. Int. J. Pharm. 2008, 349, 249-55.
16. Fahmy, T. M.; Samstein, R. M.; Harness, C. C.; Mark Saltzman, W. Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting. Biomaterials 2005, 26, 5727-36.
17. Radomsky, M. L.; Whaley, K. J.; Cone, R. A.; Saltzman, W. M.Macromolecules released from polymers: diffusion into unstirred fluids. Biomaterials 1990, 11, 619-24.
18. Saltzman, W. M.; Radomsky, M. L.; Whaley, K. J.; Cone, R. A. Antibody diffusion in human cervical mucus. Biophys. J. 1994, 66, 508-15.
19. Dong, Y.; Feng, S. S. Nanoparticles of poly(D,L-lactide)/methoxy poly(ethylene glycol)-poly(D,L-lactide) blends for controlled release of paclitaxel. J. Biomed. Mater. Res. A 2006, 78, 12-9.
20. Gref, R.; Luck, M.; Quellec, P.; Marchand, M.; Dellacherie, E.; Harnisch, S.; Blunk, T.; Muller, R. H. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf. B Biointerfaces 2000, 18, 301-313.
21. Behrens, I.; Pena, A. I.; Alonso, M. J.; Kissel, T. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm. Res. 2002, 19, 1185-93.
22. He, G.; Ma, L. L.; Pan, J.; Venkatraman, S. ABA and BAB type triblock copolymers of PEG and PLA: a comparative study of drug release properties and "stealth" particle characteristics. Int. J. Pharm. 2007, 334, 48-55.
23. Mosqueira, V. C.; Legrand, P.; Gref, R.; Heurtault, B.; Appel, M.; Barratt, G. Interactions between a macrophage cell line (J774A1) and surface-modified poly (D,L-lactide) nanocapsules bearing poly(ethylene glycol). J. Drug Targeting 1999, 7, 65-78.
24. Hawley, A. E.; Illum, L.; Davis, S. S. Preparation ofbiodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake. Pharm. Res. 1997, 14, 657-61.
25. Li, Y.; Pei, Y.; Zhang, X.; Gu, Z.; Zhou, Z.; Yuan, W.; Zhou, J.; Zhu, J.; Gao, X. PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J. Controlled Release 2001, 71, 203-11.
26. Mosqueira, V. C.; Legrand, P.; Morgat, J. L.; Vert, M.; Mysiakine, E.; Gref, R.; Devissaguet, J. P.; Barratt, G. Biodistribution oflong- circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density. Pharm. Res. 2001, 18, 1411-9.
27. Yu, J. J.; Lee, H. A.; Kim, J. H.; Kong, W. H.; Kim, Y.; Cui, Z. Y.; Park, K. G.; Kim, W. S.; Lee, H. G.; Seo, S. W. Bio-distribution and anti-tumor efficacy of PEG/PLA nano particles loaded doxorubicin. J. Drug Targeting 2007, 15, 279-84.