Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer's Disease with Plaques and Tangles

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Chu, Jin ^a   Li, Jin Guo ^a   Praticò, Domenico ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ARACHIDONATE 5 LIPOXYGENASE; CYCLIN DEPENDENT KINASE 5; GAMMA SECRETASE; PLACEBO; TAU PROTEIN; ZILEUTON;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; MALE; MEMORY DISORDER; METABOLIC REGULATION; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; COGNITION; CYCLIN-DEPENDENT KINASE 5; FEMALE; HUMANS; HYDROXYUREA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIPOXYGENASE INHIBITORS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; PLAQUE, AMYLOID; SYNAPSES; TAU PROTEINS;

EID: 84881353249     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070991     Document Type: Article

References (19)

1. Radmark O, Werz O, Steinhilber D, Samuelsson B, (2007) 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem Sci 32: 332-341.
2. Chinnici CM, Yao Y, Praticò D, (2007) The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Neurobiol. Aging 28: 1457-1462.
3. Ikonomovic MD, Abrahamson EE, Uz T, Manev H, Dekosky ST, (2008) Increased 5-Lipooxygenase immunoreactivity in hippocampus of patients with Alzheimer' diseases. J Histochem Cytochem 56: 1065-1073.
4. Qu T, Manev R, Manev H, (2001) 5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's disease. J. Neuropsychiatry Clin Neurosci 13: 304-305.
5. Firuzi O, Zhuo J, Chinnici CM, Wisniewski T, Praticò D, (2008) 5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease. FASEB J 22: 1169-1178.
6. Chu J, Praticò D, (2011) Pharmacological blockade of 5-Lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model. Am J Pathol 178 (4): 1762-1769.
7. Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Praticò D, (2012) 5-Lipoxygenase gene transfer worsens memory, amyloid and tau brain pathologies in a mouse model of Alzheimer disease. Ann Neurol 72: 442-454.
8. Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, et al. (2013) Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease. Mol Psych. 2013 Mar 12 [Epub ahead of print].
9. Riccioni G, DiIlio C, Conti P, Theoharides TC, D'Orazio N, (2004) Advances in therapy with anti-leukotriene drugs. Ann Clin Lab Sci 34: 379-387.
10. Yoshi BY, Chu J, Praticò D, (2012) Stress hormone leads to memory deficits and altered tau phosphorylation in a mouse model of Alzheimer's disease. J Alz Dis 31(1): 167-176.
11. Yang H, Zhuo J, Chu J, Chinnici C, Praticò D, (2010) Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol Psych 68 (10): 922-929.
12. Chu J, Praticò D (2011) 5-Lipoxygenase as an endogenous modulator of amyloid beta formation in vivo. Ann Neurol\ 69: 34-46, 2011.
13. Gong CX, Iqbal K, (2008) Hyperphosphorylation of microtubule-associated protein tau: A promising therapeutic target for Alzheimer disease. Curr Med Chem 15: 2321-2328.
14. Martin L, Latypova X, Terro F, (2011) Post-translational modifications of tau protein: Implications for Alzheimer's disease. Neurochem Int 58: 458-471.
15. Lee MS, Tsai LH, (2003) Cdk5: One of the links between senile plaques and neurofibrillary tangles? J Alz Dis 5: 127-137.
16. Humbert S, Dhavan R, Tsai L, (2000) p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. J Cell Sci 113: 975-983.
17. Dekosky ST, Scheff SW, (1990) Synaptic loss in frontal cortex biopsies in ad correlation with cognitive severity. Ann Neurol 27: 457-464.
18. Masliah E, Mallory M, Alford M, De Teresa R, Hansen LA, et al. (2001) Altered expression of synaptic protein occurs early progression of Alzhiemer's disease. Neurology 56: 127-129.
19. Kubavat AH, Khippal N, Tak S, Rijhwani P, Bhargava S, et al. (2013) A randomized, comparative, multicentric clinical trial to assess the efficacy and safety of zileuton extended-release tablets with montelukast sodium tablets in patients suffering from chronic persistent asthma. Am. J. Ther. 20(2): 154-162.