18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway

Toxicology in Vitro

Volumn 28, Issue 5, 2014, Pages 751-758

  Jayasooriya, Rajapaksha Gedara Prasad Tharanga ^a   Dilshara, Matharage Gayani ^a   Park, Sang Rul ^a   Choi, Yung Hyun ^b   Hyun, Jin Won ^c   Chang, Weon Young ^c   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Dong Eui University   (South Korea)

^c Jeju National University School of Medicine   (South Korea)

Author keywords

18 Glycyrrhetinic acid; Akt; Matrix metalloproteinase; Nuclear factor kappa B; Phosphatidyl inositol 3 kinase; Vascular endothelial growth factor

Indexed keywords

18 BETA GLYCYRRHETINIC ACID; ANTINEOPLASTIC AGENT; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; 18ALPHA-GLYCYRRHETINIC ACID; GLYCYRRHETINIC ACID; MMP9 PROTEIN, HUMAN; PROTEIN KINASE B; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CARCINOMA; BREAST CARCINOMA; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; PROSTATE CARCINOMA; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION; ANALOGS AND DERIVATIVES; CELL MOTION; DRUG EFFECTS; HUMAN; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; GLYCYRRHETINIC ACID; HUMANS; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84897947475     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.02.015     Document Type: Article

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